The efficacy and safety of tianeptine in the treatment of depressive disorder

Results of a controlled double-blind multicentre study vs. amitriptyline

G. Invernizzi, E. Aguglia, A. Bertolino, M. Casacchia, N. Ciani, G. F. Marchesi, M. Nardini, V. Rapisarda

Research output: Contribution to journalArticle

45 Citations (Scopus)

Abstract

Three hundred in- and outpatients suffering from depressive disorder, as diagnosed using DSM-III criteria were treated for 6 weeks under double-blind conditions in a multicenter controlled study of tianeptine vs. amitriptyline. Both groups presented steady improvement of depressive syndrome from day 7 up to the end of the treatment, as shown by all evaluation scales: HDRS, SAD, CGI. Furthermore, anxiety linked to the depressive syndrome decreased equally in both groups, as shown by the HARS measurements. In addition to the improvement of mood, the tianeptine-treated patients presented less somatic complaints and side effects when compared to the reference antidepressant. These results confirm previous findings that tianeptine is an effective antidepressant with a lower side effect profile than amitriptyline.

Original languageEnglish
Pages (from-to)85-93
Number of pages9
JournalNeuropsychobiology
Volume30
Issue number2-3
Publication statusPublished - 1994

Fingerprint

tianeptine
Amitriptyline
Depressive Disorder
Double-Blind Method
Multicenter Studies
Safety
Antidepressive Agents
Diagnostic and Statistical Manual of Mental Disorders
Inpatients
Outpatients
Therapeutics
Anxiety

Keywords

  • Acceptability
  • Amitriptyline
  • Antidepressants
  • Anxiety
  • Depression
  • Efficacy
  • Somatic complaints
  • Tianeptine

ASJC Scopus subject areas

  • Psychiatry and Mental health
  • Neuroscience(all)
  • Psychology(all)

Cite this

Invernizzi, G., Aguglia, E., Bertolino, A., Casacchia, M., Ciani, N., Marchesi, G. F., ... Rapisarda, V. (1994). The efficacy and safety of tianeptine in the treatment of depressive disorder: Results of a controlled double-blind multicentre study vs. amitriptyline. Neuropsychobiology, 30(2-3), 85-93.

The efficacy and safety of tianeptine in the treatment of depressive disorder : Results of a controlled double-blind multicentre study vs. amitriptyline. / Invernizzi, G.; Aguglia, E.; Bertolino, A.; Casacchia, M.; Ciani, N.; Marchesi, G. F.; Nardini, M.; Rapisarda, V.

In: Neuropsychobiology, Vol. 30, No. 2-3, 1994, p. 85-93.

Research output: Contribution to journalArticle

Invernizzi, G, Aguglia, E, Bertolino, A, Casacchia, M, Ciani, N, Marchesi, GF, Nardini, M & Rapisarda, V 1994, 'The efficacy and safety of tianeptine in the treatment of depressive disorder: Results of a controlled double-blind multicentre study vs. amitriptyline', Neuropsychobiology, vol. 30, no. 2-3, pp. 85-93.
Invernizzi, G. ; Aguglia, E. ; Bertolino, A. ; Casacchia, M. ; Ciani, N. ; Marchesi, G. F. ; Nardini, M. ; Rapisarda, V. / The efficacy and safety of tianeptine in the treatment of depressive disorder : Results of a controlled double-blind multicentre study vs. amitriptyline. In: Neuropsychobiology. 1994 ; Vol. 30, No. 2-3. pp. 85-93.
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