The efficacy of azimilide in the treatment of atrial fibrillation in the presence of left ventricular systolic dysfunction: Results from the Azimilide Postinfarct Survival Evaluation (ALIVE) trial

Craig M. Pratt, Steven N. Singh, Hussein R. Al-Khalidi, Jose M. Brum, Michael J. Holroyde, Stephen R. Marcello, Peter J. Schwartz, A. John Camm

Research output: Contribution to journalArticlepeer-review

Abstract

Objectives The purpose of this study was to assess the effect of oral azimilide dihydrochloride (AZ) 100 mg versus placebo on the onset, termination, and prevalence of atrial fibrillation (AF) in a subpopulation of patients in the Azimilide Postinfarct Survival Evaluation (ALIVE) trial. Background Previous clinical trials have demonstrated the antiarrhythmic effects of AZ in patients with AF. Azimilide was investigated for its effects on mortality in patients with depressed left ventricular (LV) function after recent myocardial infarction (MI) and in a subpopulation of patients with AF. Methods A total of 3,381 post-MI patients with depressed LV function were enrolled in this randomized, placebo-controlled, double-blind study of AZ 100 mg on all-cause mortality. A total of 93 patients had AF on the baseline 12-lead electrocardiogram (ECG). An additional 27 patients developed AF after initially being in sinus rhythm at randomization. These patients were identified through 12-lead ECGs obtained during routine visits at week 2, months 1, 4, 8, and 12. Results Patients with AF at baseline had a higher mortality than those without AF (p = 0.0006). Among AF patients, there was no difference in mortality between AZ patients and placebo patients (p = 0.82). Fewer AZ patients developed AF than placebo patients (p = 0.04). More AZ patients than placebo patients converted to sinus rhythm, but this difference did not achieve statistical significance (p = 0.076). Over one-year follow-up, more AZ patients were in sinus rhythm than placebo patients (p = 0.04). Conclusions Azimilide was safe and effective AF therapy in patients with depressed LV function after an MI.

Original languageEnglish
Pages (from-to)1211-1216
Number of pages6
JournalJournal of the American College of Cardiology
Volume43
Issue number7
DOIs
Publication statusPublished - Apr 7 2004

Keywords

  • AF
  • ALIVE
  • Atrial fibrillation
  • AZ
  • Azimilide dihydrochloride
  • Azimilide Postinfarct Survival Evaluation
  • CHF-STAT
  • CI
  • Confidence interval
  • DIAMOND
  • Survival Trial of Antiarrhythmic Therapy in Congestive Heart Failure

ASJC Scopus subject areas

  • Nursing(all)

Fingerprint

Dive into the research topics of 'The efficacy of azimilide in the treatment of atrial fibrillation in the presence of left ventricular systolic dysfunction: Results from the Azimilide Postinfarct Survival Evaluation (ALIVE) trial'. Together they form a unique fingerprint.

Cite this