The efficacy of hybrid chemotherapy with intravenous oxaliplatin and folinic acid and intra-hepatic infusion of 5-fluorouracil in patients with colorectal liver metastases: A phase II study

Carlo Carnaghi, Armando Santoro, Lorenza Rimassa, Roberto Doci, Riccardo Rosati, Vittorio Pedicini, Giuseppe Gullo, Monica Zuradelli, Giovanni Abbadessa, Emanuela Morenghi, Ilaria Marcon, Isabella Garassino

Research output: Contribution to journalArticle

Abstract

Intra-arterial chemotherapy in patients with liver metastases from colorectal cancer has some limitations such as hepatic toxicity and extra-hepatic progression. With the aim of overcoming these limitations, a phase II trial was designed to assess the efficacy and tolerability of a hybrid chemotherapy regimen with systemic infusion of oxaliplatin and folinic acid associated with intra-arterial 5-fluorouracil. Thirty-nine patients with colorectal liver metastases were recruited. The median age was 59 years, 30 patients (77%) had synchronous metastases, and half of the patients were chemo-naive. A total of 313 chemotherapy cycles were administered (median number 8). Treatment was well tolerated and hepatic toxicity negligible. Out of 34 evaluable patients an ORR of 41%. was observed. Eight patients (21%) underwent radical liver surgery. The median time to progression (TTP) was 10 months (range 2-63) and the median overall survival (OS) 21 months (range 6-63). Extra-hepatic progression was observed in six patients. Our results suggest that this regimen is active even if technical complications are frequent. Our aim to reduce hepatic toxicity and extra-hepatic progression was reached.

Original languageEnglish
Pages (from-to)479-485
Number of pages7
JournalInvestigational New Drugs
Volume25
Issue number5
DOIs
Publication statusPublished - Oct 2007

Keywords

  • 5-fluorouracil
  • Chemotherapy
  • Colorectal
  • Intra-arterial
  • Intra-hepatic
  • Liver
  • Metastases
  • Oxaliplatin

ASJC Scopus subject areas

  • Molecular Medicine
  • Pharmacology

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