The efficacy of sublingual immunotherapy for respiratory allergy is not affected by different dosage regimens in the induction phase

R. Sambugaro, P. Puccinelli, Samuele E. Burastero, V. Di Rienzo

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Background: Sublingual administration of allergens is a safe and effective alternative to subcutaneous immunotherapy in patients with respiratory allergies. A drawback to this therapeutic approach is the relatively long and complex management of the induction phase. Aim of the study: To determine whether different induction regimens affect the outcome of sublingual immunotherapy. Methods and results: Adult and pediatric patients with allergic rhinoconjunctivitis and/or asthma were included in the study. Ten subjects served as controls and received symptomatic treatments. Forty-three subjects were allocated to sublingual immunotherapy, with three different induction protocols (8-, 15-and 20-day, respectively). Symptom and medication scores, skin test results and (in asthmatic patients) FEV1 values were monitored for two years. Adverse effects were recorded. All induction regimens produced a significant improvement in symptom and medication usage (p <0.0001); skin test scores decreased (p <0.0001) and FEV1 improved (p <0.05). In contrast, symptom and skin test scores did not significantly change in controls. No relevant adverse effects were observed with any of the induction regimens. Conclusions: For patients with respiratory allergies, sublingual immunotherapy with an 8-day induction protocol is safe and effective. Our results encourage the usage of shorter induction regimens, which produce better compliance with this therapy.

Original languageEnglish
Pages (from-to)329-337
Number of pages9
JournalAllergologia et Immunopathologia
Issue number6
Publication statusPublished - Dec 2003



  • Allergy
  • Effectiveness
  • Induction protocol
  • Safety
  • Sublingual immunotherapy

ASJC Scopus subject areas

  • Immunology and Allergy

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