TY - JOUR
T1 - The efficiency of male-to-female and female-to-male sexual transmission of the human immunodeficiency virus
T2 - A study of 730 stable couples
AU - Nicolosi, Alfredo
AU - Leite, Maria Léa Corrêa
AU - Musicco, Massimo
AU - Arid, Claudio
AU - Gavazzeni, Giovanna
AU - Lazzarin, Adriano
AU - Angarano, Gioacchino
AU - Arici, Claudio
AU - Leite, Maria Léa Corrêa
AU - Costigliola, Paolo
AU - Gafa, Sergio
AU - Gasparini, Maddalena
AU - Gavazzeni, Giovanna
AU - Gervasoni, Cristina
AU - Lazzarin, Adriano
AU - Luzzati, Roberto
AU - Magnani, Giacomo
AU - Moroni, Mauro
AU - Musicco, Massimo
AU - Nicolosi, Alfredo
AU - Pristerà, Raffaele
AU - Puppo, Francesco
AU - Salassa, Bernardino
AU - Saracco, Alberto
AU - Sinicco, Alessandro
AU - Stellini, Roberto
AU - Tirelli, Umberto
AU - Turbessif, Giuseppe
AU - Vigevani, Gian Marco
AU - Zerboni, Roberto
PY - 1994
Y1 - 1994
N2 - To compare the efficiency of male-to-female and female-to-male sexual transmission of human immunodeficiency virus (HIV), we studied 524 female partners of HIV-infected men and 206 male partners of HIV-infected women in 16 Italian clinical centers. All of the partners had had a sexual relationship with the index case lasting for at least 6 months and presented no other risk factor than sexual exposure to the HIV-infected partner. Among the 730 couples, 24% of the female partners were HIV positive, in comparison with 10% of the male partners. Using logistic regression analysis, including gender and controlling for condom use, frequency of intercourse, anal sex, partner’s CD4+ cell count and clinical stage, sexually transmitted diseases, genital infections, and contraceptive use, we found that the efficiency of male-to-female transmission was 2.3 (95% confidence interval = 1.1–4 8) times greater than that of female-to-male transmission. Between-gender differences in the contact surfaces and the intensity of exposure to HIV during sexual intercourse are possible reasons for the difference in efficiency of transmission.
AB - To compare the efficiency of male-to-female and female-to-male sexual transmission of human immunodeficiency virus (HIV), we studied 524 female partners of HIV-infected men and 206 male partners of HIV-infected women in 16 Italian clinical centers. All of the partners had had a sexual relationship with the index case lasting for at least 6 months and presented no other risk factor than sexual exposure to the HIV-infected partner. Among the 730 couples, 24% of the female partners were HIV positive, in comparison with 10% of the male partners. Using logistic regression analysis, including gender and controlling for condom use, frequency of intercourse, anal sex, partner’s CD4+ cell count and clinical stage, sexually transmitted diseases, genital infections, and contraceptive use, we found that the efficiency of male-to-female transmission was 2.3 (95% confidence interval = 1.1–4 8) times greater than that of female-to-male transmission. Between-gender differences in the contact surfaces and the intensity of exposure to HIV during sexual intercourse are possible reasons for the difference in efficiency of transmission.
KW - AIDS
KW - Contraception
KW - Human immunodeficiency virus
KW - Interaction
KW - Risk factors
KW - Sexual behavior
KW - Sexual transmission
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M3 - Article
C2 - 7841237
AN - SCOPUS:0028113516
VL - 5
SP - 570
EP - 575
JO - Epidemiology
JF - Epidemiology
SN - 1044-3983
IS - 6
ER -