The EH network

Elisa Santolini, Anna Elisabetta Salcini, Brian K. Kay, Montarop Yamabhai, Pier Paolo Di Fiore

Research output: Contribution to journalArticlepeer-review


The EH domain is an evolutionary conserved protein-protein interaction domain present in a growing number of proteins from yeast to mammals. Even though the domain was discovered just 5 years ago, a great deal has been learned regarding its three-dimensional structure and binding specificities. Moreover, a number of cellular ligands of the domain have been identified and demonstrated to define a complex network of protein-protein interactions in the eukaryotic cell. Interestingly, many of the EH-containing and EH-binding proteins display characteristics of endocytic 'accessory' proteins, suggesting that the principal function of the EH network is to regulate various steps in endocytosis. In addition, recent evidence suggests that the EH network might work as an 'integrator' of signals controlling cellular pathways as diverse as endocytosis, nucleocytosolic export, and ultimately cell proliferation.

Original languageEnglish
Pages (from-to)186-209
Number of pages24
JournalExperimental Cell Research
Issue number1
Publication statusPublished - Nov 25 1999


  • Domains
  • EH
  • Endocytosis
  • Eps15

ASJC Scopus subject areas

  • Cell Biology


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