The EH network

Elisa Santolini, Anna Elisabetta Salcini, Brian K. Kay, Montarop Yamabhai, Pier Paolo Di Fiore

Research output: Contribution to journalArticle

Abstract

The EH domain is an evolutionary conserved protein-protein interaction domain present in a growing number of proteins from yeast to mammals. Even though the domain was discovered just 5 years ago, a great deal has been learned regarding its three-dimensional structure and binding specificities. Moreover, a number of cellular ligands of the domain have been identified and demonstrated to define a complex network of protein-protein interactions in the eukaryotic cell. Interestingly, many of the EH-containing and EH-binding proteins display characteristics of endocytic 'accessory' proteins, suggesting that the principal function of the EH network is to regulate various steps in endocytosis. In addition, recent evidence suggests that the EH network might work as an 'integrator' of signals controlling cellular pathways as diverse as endocytosis, nucleocytosolic export, and ultimately cell proliferation.

Original languageEnglish
Pages (from-to)186-209
Number of pages24
JournalExperimental Cell Research
Volume253
Issue number1
DOIs
Publication statusPublished - Nov 25 1999

Fingerprint

Endocytosis
Protein Interaction Domains and Motifs
Proteins
Fungal Proteins
Eukaryotic Cells
Mammals
Carrier Proteins
Cell Proliferation
Ligands

Keywords

  • Domains
  • EH
  • Endocytosis
  • Eps15

ASJC Scopus subject areas

  • Cell Biology

Cite this

Santolini, E., Salcini, A. E., Kay, B. K., Yamabhai, M., & Di Fiore, P. P. (1999). The EH network. Experimental Cell Research, 253(1), 186-209. https://doi.org/10.1006/excr.1999.4694

The EH network. / Santolini, Elisa; Salcini, Anna Elisabetta; Kay, Brian K.; Yamabhai, Montarop; Di Fiore, Pier Paolo.

In: Experimental Cell Research, Vol. 253, No. 1, 25.11.1999, p. 186-209.

Research output: Contribution to journalArticle

Santolini, E, Salcini, AE, Kay, BK, Yamabhai, M & Di Fiore, PP 1999, 'The EH network', Experimental Cell Research, vol. 253, no. 1, pp. 186-209. https://doi.org/10.1006/excr.1999.4694
Santolini E, Salcini AE, Kay BK, Yamabhai M, Di Fiore PP. The EH network. Experimental Cell Research. 1999 Nov 25;253(1):186-209. https://doi.org/10.1006/excr.1999.4694
Santolini, Elisa ; Salcini, Anna Elisabetta ; Kay, Brian K. ; Yamabhai, Montarop ; Di Fiore, Pier Paolo. / The EH network. In: Experimental Cell Research. 1999 ; Vol. 253, No. 1. pp. 186-209.
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