Abstract
We have PCR-amplified cDNA sequence of the "embryonic" γ subunit of muscle acetylcholine receptor (AChR) from adult bovine extraocular muscle (EOM). We cloned and sequenced this product and used it to probe Northern blots. We detected the γ subunit in EOM mRNA, but not in control skeletal muscle. The presence of γ subunit in EOMs may explain their preferential involvement in myasthenia gravis, where an autoimmune response to the γ subunit is generally present.
Original language | English |
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Pages (from-to) | 983-986 |
Number of pages | 4 |
Journal | Neurology |
Volume | 43 |
Issue number | 5 |
Publication status | Published - May 1993 |
ASJC Scopus subject areas
- Neuroscience(all)
- Arts and Humanities (miscellaneous)
- Clinical Neurology