We have PCR-amplified cDNA sequence of the "embryonic" γ subunit of muscle acetylcholine receptor (AChR) from adult bovine extraocular muscle (EOM). We cloned and sequenced this product and used it to probe Northern blots. We detected the γ subunit in EOM mRNA, but not in control skeletal muscle. The presence of γ subunit in EOMs may explain their preferential involvement in myasthenia gravis, where an autoimmune response to the γ subunit is generally present.
|Number of pages||4|
|Publication status||Published - May 1993|
ASJC Scopus subject areas
- Arts and Humanities (miscellaneous)
- Clinical Neurology