The 'embryonic' gamma subunit of the nicotinic acetylcholine receptor is expressed in adult extraocular muscle

Robert M. Horton; Angelo A. Manfredi; Bianca M. Conti-Tronconi

The 'embryonic' gamma subunit of the nicotinic acetylcholine receptor is expressed in adult extraocular muscle

Robert M. Horton, Angelo A. Manfredi, Bianca M. Conti-Tronconi

IRCCS Ospedale San Raffaele

Research output: Contribution to journal › Article › peer-review

Abstract

We have PCR-amplified cDNA sequence of the "embryonic" γ subunit of muscle acetylcholine receptor (AChR) from adult bovine extraocular muscle (EOM). We cloned and sequenced this product and used it to probe Northern blots. We detected the γ subunit in EOM mRNA, but not in control skeletal muscle. The presence of γ subunit in EOMs may explain their preferential involvement in myasthenia gravis, where an autoimmune response to the γ subunit is generally present.

Original language	English
Pages (from-to)	983-986
Number of pages	4
Journal	Neurology
Volume	43
Issue number	5
Publication status	Published - May 1993

ASJC Scopus subject areas

Neuroscience(all)
Arts and Humanities (miscellaneous)
Clinical Neurology

Cite this

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AU - Manfredi, Angelo A.

AU - Conti-Tronconi, Bianca M.

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N2 - We have PCR-amplified cDNA sequence of the "embryonic" γ subunit of muscle acetylcholine receptor (AChR) from adult bovine extraocular muscle (EOM). We cloned and sequenced this product and used it to probe Northern blots. We detected the γ subunit in EOM mRNA, but not in control skeletal muscle. The presence of γ subunit in EOMs may explain their preferential involvement in myasthenia gravis, where an autoimmune response to the γ subunit is generally present.

AB - We have PCR-amplified cDNA sequence of the "embryonic" γ subunit of muscle acetylcholine receptor (AChR) from adult bovine extraocular muscle (EOM). We cloned and sequenced this product and used it to probe Northern blots. We detected the γ subunit in EOM mRNA, but not in control skeletal muscle. The presence of γ subunit in EOMs may explain their preferential involvement in myasthenia gravis, where an autoimmune response to the γ subunit is generally present.

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The 'embryonic' gamma subunit of the nicotinic acetylcholine receptor is expressed in adult extraocular muscle

Abstract

ASJC Scopus subject areas

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