Abstract
We have PCR-amplified cDNA sequence of the "embryonic" γ subunit of muscle acetylcholine receptor (AChR) from adult bovine extraocular muscle (EOM). We cloned and sequenced this product and used it to probe Northern blots. We detected the γ subunit in EOM mRNA, but not in control skeletal muscle. The presence of γ subunit in EOMs may explain their preferential involvement in myasthenia gravis, where an autoimmune response to the γ subunit is generally present.
| Original language | English |
|---|---|
| Pages (from-to) | 983-986 |
| Number of pages | 4 |
| Journal | Neurology |
| Volume | 43 |
| Issue number | 5 |
| Publication status | Published - May 1993 |
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ASJC Scopus subject areas
- Neuroscience(all)
- Arts and Humanities (miscellaneous)
- Clinical Neurology
Cite this
The 'embryonic' gamma subunit of the nicotinic acetylcholine receptor is expressed in adult extraocular muscle. / Horton, Robert M.; Manfredi, Angelo A.; Conti-Tronconi, Bianca M.
In: Neurology, Vol. 43, No. 5, 05.1993, p. 983-986.Research output: Contribution to journal › Article
}
TY - JOUR
T1 - The 'embryonic' gamma subunit of the nicotinic acetylcholine receptor is expressed in adult extraocular muscle
AU - Horton, Robert M.
AU - Manfredi, Angelo A.
AU - Conti-Tronconi, Bianca M.
PY - 1993/5
Y1 - 1993/5
N2 - We have PCR-amplified cDNA sequence of the "embryonic" γ subunit of muscle acetylcholine receptor (AChR) from adult bovine extraocular muscle (EOM). We cloned and sequenced this product and used it to probe Northern blots. We detected the γ subunit in EOM mRNA, but not in control skeletal muscle. The presence of γ subunit in EOMs may explain their preferential involvement in myasthenia gravis, where an autoimmune response to the γ subunit is generally present.
AB - We have PCR-amplified cDNA sequence of the "embryonic" γ subunit of muscle acetylcholine receptor (AChR) from adult bovine extraocular muscle (EOM). We cloned and sequenced this product and used it to probe Northern blots. We detected the γ subunit in EOM mRNA, but not in control skeletal muscle. The presence of γ subunit in EOMs may explain their preferential involvement in myasthenia gravis, where an autoimmune response to the γ subunit is generally present.
UR - http://www.scopus.com/inward/record.url?scp=0027315047&partnerID=8YFLogxK
UR - http://www.scopus.com/inward/citedby.url?scp=0027315047&partnerID=8YFLogxK
M3 - Article
C2 - 7684117
AN - SCOPUS:0027315047
VL - 43
SP - 983
EP - 986
JO - Neurology
JF - Neurology
SN - 0028-3878
IS - 5
ER -