The 'embryonic' gamma subunit of the nicotinic acetylcholine receptor is expressed in adult extraocular muscle

Robert M. Horton, Angelo A. Manfredi, Bianca M. Conti-Tronconi

Research output: Contribution to journalArticle

Abstract

We have PCR-amplified cDNA sequence of the "embryonic" γ subunit of muscle acetylcholine receptor (AChR) from adult bovine extraocular muscle (EOM). We cloned and sequenced this product and used it to probe Northern blots. We detected the γ subunit in EOM mRNA, but not in control skeletal muscle. The presence of γ subunit in EOMs may explain their preferential involvement in myasthenia gravis, where an autoimmune response to the γ subunit is generally present.

Original languageEnglish
Pages (from-to)983-986
Number of pages4
JournalNeurology
Volume43
Issue number5
Publication statusPublished - May 1993

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Oculomotor Muscles
Nicotinic Receptors
Myasthenia Gravis
Cholinergic Receptors
Autoimmunity
Northern Blotting
Skeletal Muscle
Complementary DNA
Muscles
Polymerase Chain Reaction
Messenger RNA

ASJC Scopus subject areas

  • Neuroscience(all)
  • Arts and Humanities (miscellaneous)
  • Clinical Neurology

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The 'embryonic' gamma subunit of the nicotinic acetylcholine receptor is expressed in adult extraocular muscle. / Horton, Robert M.; Manfredi, Angelo A.; Conti-Tronconi, Bianca M.

In: Neurology, Vol. 43, No. 5, 05.1993, p. 983-986.

Research output: Contribution to journalArticle

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