The emergence of genomics in mouse asthma models

E. Stupka

Research output: Contribution to journalArticle

1 Citation (Scopus)

Abstract

Genomics has become a pervasive tool in biomedical research empowering basic research in models of disease as well as discovery of novel biomarkers. In the field of asthma the effort in this field has only begun recently, with a dozen experiments published up to date. The studies published so far shed light on the transcriptional networks underlying allergic inflammation, mostly on the basis of models of ovalbumin-induced acute inflammation. They also explore the specific effects on transcription of therapeutic compounds, environmental agents, genetic manipulations and different genetic backgrounds, thus providing a rich baseline description of different molecular states underlying the disease. On the contrary there has been no investigation so far of the dynamics of both initiation and manifestation of allergy, with almost all studies focusing on a single time point. Similarly, other aspects of genomics (e.g. epigenomics, chromatin interactions, microRNAs and ncRNAs) remain almost completely unexplored and are likely to benefit from the recent development of next-generation sequencing approaches.

Original languageEnglish
Pages (from-to)119-127
Number of pages9
JournalDrug Discovery Today: Disease Models
Volume6
Issue number4
DOIs
Publication statusPublished - Dec 2009

Fingerprint

Genomics
Asthma
Inflammation
Gene Regulatory Networks
Ovalbumin
MicroRNAs
Epigenomics
Chromatin
Biomedical Research
Hypersensitivity
Biomarkers
Research
Therapeutics
Genetic Background

ASJC Scopus subject areas

  • Molecular Medicine
  • Drug Discovery

Cite this

The emergence of genomics in mouse asthma models. / Stupka, E.

In: Drug Discovery Today: Disease Models, Vol. 6, No. 4, 12.2009, p. 119-127.

Research output: Contribution to journalArticle

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