TY - JOUR
T1 - The emerging multiple roles of nuclear Akt
AU - Martelli, Alberto M.
AU - Tabellini, Giovanna
AU - Bressanin, Daniela
AU - Ognibene, Andrea
AU - Goto, Kaoru
AU - Cocco, Lucio
AU - Evangelisti, Camilla
PY - 2012/12
Y1 - 2012/12
N2 - Akt is a central player in the signal transduction pathways activated in response to many growth factors, hormones, cytokines, and nutrients and is thought to control a myriad of cellular functions including proliferation and survival, autophagy, metabolism, angiogenesis, motility, and exocytosis. Moreover, dysregulated Akt activity is being implicated in the pathogenesis of a growing number of disorders, including cancer. Evidence accumulated over the past 15. years has highlighted the presence of active Akt in the nucleus, where it acts as a fundamental component of key signaling pathways. For example, nuclear Akt counteracts apoptosis through a block of caspase-activated DNase: deoxyribonuclease and inhibition of chromatin condensation, and is also involved in cell cycle progression control, cell differentiation, mRNA: messenger RNA export, DNA repair, and tumorigenesis. In this review, we shall summarize the most relevant findings about nuclear Akt and its functions.
AB - Akt is a central player in the signal transduction pathways activated in response to many growth factors, hormones, cytokines, and nutrients and is thought to control a myriad of cellular functions including proliferation and survival, autophagy, metabolism, angiogenesis, motility, and exocytosis. Moreover, dysregulated Akt activity is being implicated in the pathogenesis of a growing number of disorders, including cancer. Evidence accumulated over the past 15. years has highlighted the presence of active Akt in the nucleus, where it acts as a fundamental component of key signaling pathways. For example, nuclear Akt counteracts apoptosis through a block of caspase-activated DNase: deoxyribonuclease and inhibition of chromatin condensation, and is also involved in cell cycle progression control, cell differentiation, mRNA: messenger RNA export, DNA repair, and tumorigenesis. In this review, we shall summarize the most relevant findings about nuclear Akt and its functions.
KW - Akt
KW - Cell proliferation
KW - Cell survival
KW - MRNA export
KW - Nucleus
KW - Tumorigenesis
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U2 - 10.1016/j.bbamcr.2012.08.017
DO - 10.1016/j.bbamcr.2012.08.017
M3 - Article
C2 - 22960641
AN - SCOPUS:84867283425
VL - 1823
SP - 2168
EP - 2178
JO - Biochimica et Biophysica Acta - Molecular Cell Research
JF - Biochimica et Biophysica Acta - Molecular Cell Research
SN - 0167-4889
IS - 12
ER -