The emerging multiple roles of nuclear Akt

Alberto M. Martelli, Giovanna Tabellini, Daniela Bressanin, Andrea Ognibene, Kaoru Goto, Lucio Cocco, Camilla Evangelisti

Research output: Contribution to journalArticlepeer-review

Abstract

Akt is a central player in the signal transduction pathways activated in response to many growth factors, hormones, cytokines, and nutrients and is thought to control a myriad of cellular functions including proliferation and survival, autophagy, metabolism, angiogenesis, motility, and exocytosis. Moreover, dysregulated Akt activity is being implicated in the pathogenesis of a growing number of disorders, including cancer. Evidence accumulated over the past 15. years has highlighted the presence of active Akt in the nucleus, where it acts as a fundamental component of key signaling pathways. For example, nuclear Akt counteracts apoptosis through a block of caspase-activated DNase: deoxyribonuclease and inhibition of chromatin condensation, and is also involved in cell cycle progression control, cell differentiation, mRNA: messenger RNA export, DNA repair, and tumorigenesis. In this review, we shall summarize the most relevant findings about nuclear Akt and its functions.

Original languageEnglish
Pages (from-to)2168-2178
Number of pages11
JournalBiochimica et Biophysica Acta - Molecular Cell Research
Volume1823
Issue number12
DOIs
Publication statusPublished - Dec 2012

Keywords

  • Akt
  • Cell proliferation
  • Cell survival
  • MRNA export
  • Nucleus
  • Tumorigenesis

ASJC Scopus subject areas

  • Cell Biology
  • Molecular Biology

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