The emerging role of Acid Sphingomyelinase in autophagy

Cristiana Perrotta, Davide Cervia, Clara De Palma, Emma Assi, Paolo Pellegrino, Maria Teresa Bassi, Emilio Clementi

Research output: Contribution to journalArticle

Abstract

Autophagy, the main intracellular process of cytoplasmic material degradation, is involved in cell survival and death. Autophagy is regulated at various levels and novel modulators of its function are being continuously identified. An intriguing recent observation is that among these modulators is the sphingolipid metabolising enzyme, Acid Sphingomyelinase (A-SMase), already known to play a fundamental role in apoptotic cell death participating in several pathophysiological conditions. In this review we analyse and discuss the relationship between autophagy and A-SMase describing how A-SMase may regulate it and defining, for the first time, the existence of an A-SMase-autophagy axis. The imbalance of this axis plays a role in cancer, nervous system, cardiovascular, and hepatic disorders.

Original languageEnglish
Pages (from-to)635-644
Number of pages10
JournalApoptosis
Volume20
Issue number5
DOIs
Publication statusPublished - Mar 30 2015

Fingerprint

Sphingomyelin Phosphodiesterase
Autophagy
Acids
Modulators
Cell Death
Sphingolipids
Neurology
Cell death
Nervous System
Cell Survival
Cells
Observation
Degradation
Liver
Enzymes
Neoplasms

Keywords

  • Acid Sphingomyelinase
  • Autophagic signalling
  • Autophagy
  • Autophagy-related diseases
  • Lysosomes

ASJC Scopus subject areas

  • Cell Biology
  • Clinical Biochemistry
  • Biochemistry, medical
  • Cancer Research
  • Pharmaceutical Science
  • Pharmacology
  • Medicine(all)

Cite this

Perrotta, C., Cervia, D., De Palma, C., Assi, E., Pellegrino, P., Bassi, M. T., & Clementi, E. (2015). The emerging role of Acid Sphingomyelinase in autophagy. Apoptosis, 20(5), 635-644. https://doi.org/10.1007/s10495-015-1101-9

The emerging role of Acid Sphingomyelinase in autophagy. / Perrotta, Cristiana; Cervia, Davide; De Palma, Clara; Assi, Emma; Pellegrino, Paolo; Bassi, Maria Teresa; Clementi, Emilio.

In: Apoptosis, Vol. 20, No. 5, 30.03.2015, p. 635-644.

Research output: Contribution to journalArticle

Perrotta, C, Cervia, D, De Palma, C, Assi, E, Pellegrino, P, Bassi, MT & Clementi, E 2015, 'The emerging role of Acid Sphingomyelinase in autophagy', Apoptosis, vol. 20, no. 5, pp. 635-644. https://doi.org/10.1007/s10495-015-1101-9
Perrotta C, Cervia D, De Palma C, Assi E, Pellegrino P, Bassi MT et al. The emerging role of Acid Sphingomyelinase in autophagy. Apoptosis. 2015 Mar 30;20(5):635-644. https://doi.org/10.1007/s10495-015-1101-9
Perrotta, Cristiana ; Cervia, Davide ; De Palma, Clara ; Assi, Emma ; Pellegrino, Paolo ; Bassi, Maria Teresa ; Clementi, Emilio. / The emerging role of Acid Sphingomyelinase in autophagy. In: Apoptosis. 2015 ; Vol. 20, No. 5. pp. 635-644.
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