The emerging role of interleukin (IL)-1 in the pathogenesis and treatment of inflammatory and degenerative eye diseases

Claudia Fabiani, Jurgen Sota, Gian Marco Tosi, Rossella Franceschini, Bruno Frediani, Mauro Galeazzi, Donato Rigante, Luca Cantarini

Research output: Contribution to journalArticle

Abstract

Interleukin (IL)-1 plays a key role in the pathogenesis and thereafter in the search for specific treatments of different inflammatory and degenerative eye diseases. Indeed, an overactivity of IL-1 might be an initiating factor for many immunopathologic sceneries in the eye, as proven by the efficacy of the specific IL-1 blockade in different ocular diseases. For instance, the uveitis in monogenic autoinflammatory disorders, such as Blau syndrome and cryopyrin-associated periodic syndrome, or in complex polygenic autoinflammatory disorders, such as Behçet’s disease, has been successfully treated with IL-1 blockers. Similarly, therapy with the IL-1 receptor antagonist anakinra has proven successful also in scleritis and episcleritis in the context of different rheumatic conditions. Moreover, interesting findings deriving from animal models of ocular disease have set a rational basis from a therapeutic viewpoint to manage patients also with dry eye disease and a broadening number of ocular inflammatory and degenerative conditions, which start from an imbalance between IL-1 and its receptor antagonist.

Original languageEnglish
Pages (from-to)1-12
Number of pages12
JournalClinical Rheumatology
DOIs
Publication statusAccepted/In press - Dec 28 2016

Keywords

  • Diabetic retinopathy
  • Dry-eye
  • Keratitis
  • Macular degeneration
  • Scleritis
  • Uveitis

ASJC Scopus subject areas

  • Rheumatology

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    Fabiani, C., Sota, J., Tosi, G. M., Franceschini, R., Frediani, B., Galeazzi, M., Rigante, D., & Cantarini, L. (Accepted/In press). The emerging role of interleukin (IL)-1 in the pathogenesis and treatment of inflammatory and degenerative eye diseases. Clinical Rheumatology, 1-12. https://doi.org/10.1007/s10067-016-3527-z