The Emerging Role of Microbial Biofilm in Lyme Neuroborreliosis

E. G. Di Domenico, I. Cavallo, V. Bordignon, G. D'Agosto, M. Pontone, E. Trento, M. T. Gallo, G. Prignano, F. Pimpinelli, L. Toma, F. Ensoli

Research output: Contribution to journalArticle

Abstract

Lyme borreliosis (LB) is the most common tick-borne disease caused by the spirochete Borrelia burgdorferi in North America and Borrelia afzelii or Borrelia garinii in Europe and Asia, respectively. The infection affects multiple organ systems, including the skin, joints, and the nervous system. Lyme neuroborreliosis (LNB) is the most dangerous manifestation of Lyme disease, occurring in 10-15% of infected individuals. During the course of the infection, bacteria migrate through the host tissues altering the coagulation and fibrinolysis pathways and the immune response, reaching the central nervous system (CNS) within 2 weeks after the bite of an infected tick. The early treatment with oral antimicrobials is effective in the majority of patients with LNB. Nevertheless, persistent forms of LNB are relatively common, despite targeted antibiotic therapy. It has been observed that the antibiotic resistance and the reoccurrence of Lyme disease are associated with biofilm-like aggregates in B. burgdorferi, B. afzelii, and B. garinii, both in vitro and in vivo, allowing Borrelia spp. to resist to adverse environmental conditions. Indeed, the increased tolerance to antibiotics described in the persisting forms of Borrelia spp., is strongly reminiscent of biofilm growing bacteria, suggesting a possible role of biofilm aggregates in the development of the different manifestations of Lyme disease including LNB.
Original languageEnglish
Pages (from-to)1048
Number of pages1
JournalFrontiers in Neurology
Volume9
DOIs
Publication statusPublished - Dec 3 2018
Externally publishedYes

Fingerprint

Lyme Neuroborreliosis
Borrelia burgdorferi Group
Lyme Disease
Biofilms
Borrelia
Borrelia burgdorferi
Tick-Borne Diseases
Tick Bites
Anti-Bacterial Agents
Bacteria
Spirochaetales
Fibrinolysis
Microbial Drug Resistance
North America
Infection
Nervous System
Central Nervous System
Joints
Skin
Therapeutics

Keywords

  • Borrelia
  • biofilm
  • erythema migrans
  • lyme
  • neuroborreliosis
  • skin

Cite this

Domenico, E. G. D., Cavallo, I., Bordignon, V., D'Agosto, G., Pontone, M., Trento, E., ... Ensoli, F. (2018). The Emerging Role of Microbial Biofilm in Lyme Neuroborreliosis. Frontiers in Neurology, 9, 1048. https://doi.org/10.3389/fneur.2018.01048 [doi]

The Emerging Role of Microbial Biofilm in Lyme Neuroborreliosis. / Domenico, E. G. Di; Cavallo, I.; Bordignon, V.; D'Agosto, G.; Pontone, M.; Trento, E.; Gallo, M. T.; Prignano, G.; Pimpinelli, F.; Toma, L.; Ensoli, F.

In: Frontiers in Neurology, Vol. 9, 03.12.2018, p. 1048.

Research output: Contribution to journalArticle

Domenico, EGD, Cavallo, I, Bordignon, V, D'Agosto, G, Pontone, M, Trento, E, Gallo, MT, Prignano, G, Pimpinelli, F, Toma, L & Ensoli, F 2018, 'The Emerging Role of Microbial Biofilm in Lyme Neuroborreliosis', Frontiers in Neurology, vol. 9, pp. 1048. https://doi.org/10.3389/fneur.2018.01048 [doi]
Domenico EGD, Cavallo I, Bordignon V, D'Agosto G, Pontone M, Trento E et al. The Emerging Role of Microbial Biofilm in Lyme Neuroborreliosis. Frontiers in Neurology. 2018 Dec 3;9:1048. https://doi.org/10.3389/fneur.2018.01048 [doi]
Domenico, E. G. Di ; Cavallo, I. ; Bordignon, V. ; D'Agosto, G. ; Pontone, M. ; Trento, E. ; Gallo, M. T. ; Prignano, G. ; Pimpinelli, F. ; Toma, L. ; Ensoli, F. / The Emerging Role of Microbial Biofilm in Lyme Neuroborreliosis. In: Frontiers in Neurology. 2018 ; Vol. 9. pp. 1048.
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