TY - JOUR
T1 - The emerging role of obesity, diet and lipid metabolism in prostate cancer
AU - Ferro, Matteo
AU - Terracciano, Daniela
AU - Buonerba, Carlo
AU - Lucarelli, Giuseppe
AU - Bottero, Danilo
AU - Perdonà, Sisto
AU - Autorino, Riccardo
AU - Serino, Alessandro
AU - Cantiello, Francesco
AU - Damiano, Rocco
AU - Andras, Iulia
AU - Placido, Sabino De
AU - Di Lorenzo, Giuseppe
AU - Battaglia, Michele
AU - Jereczek-Fossa, Barbara A.
AU - Mirone, Vincenzo
AU - De Cobelli, Ottavio
PY - 2017/2/1
Y1 - 2017/2/1
N2 - Obesity is associated with an increased risk of a number of serious medical conditions, including cancer. As far as prostate cancer is concerned, obesity is associated with an increased risk of high-grade tumors, which is possibly related to lower androgen levels. Diet may also affect prostate cancer risk since countries with a higher dietary fat intake also present higher prostate cancer mortality rates. Interestingly, prostate cancer is associated with a number of metabolic alterations that may provide valuable diagnostic and therapeutic targets. This review explores the available clinical as well as biological evidence supporting the relationship between obesity, diet, alteration in metabolic pathways and prostate cancer.
AB - Obesity is associated with an increased risk of a number of serious medical conditions, including cancer. As far as prostate cancer is concerned, obesity is associated with an increased risk of high-grade tumors, which is possibly related to lower androgen levels. Diet may also affect prostate cancer risk since countries with a higher dietary fat intake also present higher prostate cancer mortality rates. Interestingly, prostate cancer is associated with a number of metabolic alterations that may provide valuable diagnostic and therapeutic targets. This review explores the available clinical as well as biological evidence supporting the relationship between obesity, diet, alteration in metabolic pathways and prostate cancer.
KW - diet
KW - obesity
KW - urologic/prostate
UR - http://www.scopus.com/inward/record.url?scp=85009455139&partnerID=8YFLogxK
UR - http://www.scopus.com/inward/citedby.url?scp=85009455139&partnerID=8YFLogxK
U2 - 10.2217/fon-2016-0217
DO - 10.2217/fon-2016-0217
M3 - Review article
AN - SCOPUS:85009455139
VL - 13
SP - 285
EP - 293
JO - Future Oncology
JF - Future Oncology
SN - 1479-6694
IS - 3
ER -