The emerging role of soluble HLA-G in the control of chemotaxis

Fabio Morandi; Nathalie Rouas-Freiss; Vito Pistoia

doi:10.1016/j.cytogfr.2014.04.004

The emerging role of soluble HLA-G in the control of chemotaxis

Fabio Morandi, Nathalie Rouas-Freiss, Vito Pistoia

Istituto "Giannina Gaslini"

Research output: Contribution to journal › Article › peer-review

Abstract

HLA-G is an immunosuppressive molecule, that impairs the function of different immune cell populations, both in physiological and pathological conditions. Here, we have analyzed data obtained by our group and others regarding sHLA-G concentration in plasma from patients with different diseases. Next, we have summarized novel data regarding the impairment of chemotaxis of different immune effector cells mediated by sHLA-G. Finally, we have discussed the impact of this function on the immune response during cancer, viral infection, autoimmunity, and on B cell differentiation in secondary lymphoid organs. In conclusion, we have delineated a role of sHLA-G in the control of chemotaxis of immune effector cells, that may be relevant to modulate immune responses in different settings.

Original language	English
Pages (from-to)	327-335
Number of pages	9
Journal	Cytokine and Growth Factor Reviews
Volume	25
Issue number	3
DOIs	https://doi.org/10.1016/j.cytogfr.2014.04.004
Publication status	Published - 2014

Keywords

Chemokine receptors
Chemotaxis
HLA-G

ASJC Scopus subject areas

Immunology
Endocrinology, Diabetes and Metabolism
Immunology and Allergy
Biochemistry, Genetics and Molecular Biology(all)
Medicine(all)

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AU - Rouas-Freiss, Nathalie

AU - Pistoia, Vito

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AB - HLA-G is an immunosuppressive molecule, that impairs the function of different immune cell populations, both in physiological and pathological conditions. Here, we have analyzed data obtained by our group and others regarding sHLA-G concentration in plasma from patients with different diseases. Next, we have summarized novel data regarding the impairment of chemotaxis of different immune effector cells mediated by sHLA-G. Finally, we have discussed the impact of this function on the immune response during cancer, viral infection, autoimmunity, and on B cell differentiation in secondary lymphoid organs. In conclusion, we have delineated a role of sHLA-G in the control of chemotaxis of immune effector cells, that may be relevant to modulate immune responses in different settings.

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The emerging role of soluble HLA-G in the control of chemotaxis

Abstract

Keywords

ASJC Scopus subject areas

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