Abstract
HLA-G is an immunosuppressive molecule, that impairs the function of different immune cell populations, both in physiological and pathological conditions. Here, we have analyzed data obtained by our group and others regarding sHLA-G concentration in plasma from patients with different diseases. Next, we have summarized novel data regarding the impairment of chemotaxis of different immune effector cells mediated by sHLA-G. Finally, we have discussed the impact of this function on the immune response during cancer, viral infection, autoimmunity, and on B cell differentiation in secondary lymphoid organs. In conclusion, we have delineated a role of sHLA-G in the control of chemotaxis of immune effector cells, that may be relevant to modulate immune responses in different settings.
| Original language | English |
|---|---|
| Pages (from-to) | 327-335 |
| Number of pages | 9 |
| Journal | Cytokine and Growth Factor Reviews |
| Volume | 25 |
| Issue number | 3 |
| DOIs | |
| Publication status | Published - 2014 |
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Keywords
- Chemokine receptors
- Chemotaxis
- HLA-G
ASJC Scopus subject areas
- Immunology
- Endocrinology, Diabetes and Metabolism
- Immunology and Allergy
- Biochemistry, Genetics and Molecular Biology(all)
- Medicine(all)
Cite this
The emerging role of soluble HLA-G in the control of chemotaxis. / Morandi, Fabio; Rouas-Freiss, Nathalie; Pistoia, Vito.
In: Cytokine and Growth Factor Reviews, Vol. 25, No. 3, 2014, p. 327-335.Research output: Contribution to journal › Article
}
TY - JOUR
T1 - The emerging role of soluble HLA-G in the control of chemotaxis
AU - Morandi, Fabio
AU - Rouas-Freiss, Nathalie
AU - Pistoia, Vito
PY - 2014
Y1 - 2014
N2 - HLA-G is an immunosuppressive molecule, that impairs the function of different immune cell populations, both in physiological and pathological conditions. Here, we have analyzed data obtained by our group and others regarding sHLA-G concentration in plasma from patients with different diseases. Next, we have summarized novel data regarding the impairment of chemotaxis of different immune effector cells mediated by sHLA-G. Finally, we have discussed the impact of this function on the immune response during cancer, viral infection, autoimmunity, and on B cell differentiation in secondary lymphoid organs. In conclusion, we have delineated a role of sHLA-G in the control of chemotaxis of immune effector cells, that may be relevant to modulate immune responses in different settings.
AB - HLA-G is an immunosuppressive molecule, that impairs the function of different immune cell populations, both in physiological and pathological conditions. Here, we have analyzed data obtained by our group and others regarding sHLA-G concentration in plasma from patients with different diseases. Next, we have summarized novel data regarding the impairment of chemotaxis of different immune effector cells mediated by sHLA-G. Finally, we have discussed the impact of this function on the immune response during cancer, viral infection, autoimmunity, and on B cell differentiation in secondary lymphoid organs. In conclusion, we have delineated a role of sHLA-G in the control of chemotaxis of immune effector cells, that may be relevant to modulate immune responses in different settings.
KW - Chemokine receptors
KW - Chemotaxis
KW - HLA-G
UR - http://www.scopus.com/inward/record.url?scp=84902077948&partnerID=8YFLogxK
UR - http://www.scopus.com/inward/citedby.url?scp=84902077948&partnerID=8YFLogxK
U2 - 10.1016/j.cytogfr.2014.04.004
DO - 10.1016/j.cytogfr.2014.04.004
M3 - Article
C2 - 24882150
AN - SCOPUS:84902077948
VL - 25
SP - 327
EP - 335
JO - Cytokine and Growth Factor Reviews
JF - Cytokine and Growth Factor Reviews
SN - 1359-6101
IS - 3
ER -