The emerging role of soluble HLA-G in the control of chemotaxis

Fabio Morandi, Nathalie Rouas-Freiss, Vito Pistoia

Research output: Contribution to journalArticle

Abstract

HLA-G is an immunosuppressive molecule, that impairs the function of different immune cell populations, both in physiological and pathological conditions. Here, we have analyzed data obtained by our group and others regarding sHLA-G concentration in plasma from patients with different diseases. Next, we have summarized novel data regarding the impairment of chemotaxis of different immune effector cells mediated by sHLA-G. Finally, we have discussed the impact of this function on the immune response during cancer, viral infection, autoimmunity, and on B cell differentiation in secondary lymphoid organs. In conclusion, we have delineated a role of sHLA-G in the control of chemotaxis of immune effector cells, that may be relevant to modulate immune responses in different settings.

Original languageEnglish
Pages (from-to)327-335
Number of pages9
JournalCytokine and Growth Factor Reviews
Volume25
Issue number3
DOIs
Publication statusPublished - 2014

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Keywords

  • Chemokine receptors
  • Chemotaxis
  • HLA-G

ASJC Scopus subject areas

  • Immunology
  • Endocrinology, Diabetes and Metabolism
  • Immunology and Allergy
  • Biochemistry, Genetics and Molecular Biology(all)
  • Medicine(all)

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