Abstract
The spread of malaria relies on the ability of the Plasmodium parasites to be transmitted from infected individuals to the Anopheles mosquito vectors. Recent work on the most lethal of the malaria parasites, Plasmodium falciparum, identified the infected human bone marrow as a preferential site for the localization and maturation of the parasite transmission stages, the gametocytes. These findings unveil a complex host parasite interplay and an unsuspected role of the bone marrow microenvironment in the successful transmission of the malaria parasite and have major implications in developing and targeting future interventions to block the transmission of P. falciparum.
| Original language | English |
|---|---|
| Pages (from-to) | 96-99 |
| Number of pages | 4 |
| Journal | Annali dell'Istituto Superiore di Sanita |
| Volume | 53 |
| Issue number | 2 |
| DOIs | |
| Publication status | Published - Jan 1 2017 |
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Keywords
- Bone marrow
- Gametocytes
- Malaria
- Plasmodium transmission
- Stromal microenvironment
ASJC Scopus subject areas
- Public Health, Environmental and Occupational Health
Cite this
The emerging role of the human bone marrow as a privileged developmental niche for the transmission stages of the malaria parasite Plasmodium falciparum. / Alano, Pietro.
In: Annali dell'Istituto Superiore di Sanita, Vol. 53, No. 2, 01.01.2017, p. 96-99.Research output: Contribution to journal › Review article
}
TY - JOUR
T1 - The emerging role of the human bone marrow as a privileged developmental niche for the transmission stages of the malaria parasite Plasmodium falciparum
AU - Alano, Pietro
PY - 2017/1/1
Y1 - 2017/1/1
N2 - The spread of malaria relies on the ability of the Plasmodium parasites to be transmitted from infected individuals to the Anopheles mosquito vectors. Recent work on the most lethal of the malaria parasites, Plasmodium falciparum, identified the infected human bone marrow as a preferential site for the localization and maturation of the parasite transmission stages, the gametocytes. These findings unveil a complex host parasite interplay and an unsuspected role of the bone marrow microenvironment in the successful transmission of the malaria parasite and have major implications in developing and targeting future interventions to block the transmission of P. falciparum.
AB - The spread of malaria relies on the ability of the Plasmodium parasites to be transmitted from infected individuals to the Anopheles mosquito vectors. Recent work on the most lethal of the malaria parasites, Plasmodium falciparum, identified the infected human bone marrow as a preferential site for the localization and maturation of the parasite transmission stages, the gametocytes. These findings unveil a complex host parasite interplay and an unsuspected role of the bone marrow microenvironment in the successful transmission of the malaria parasite and have major implications in developing and targeting future interventions to block the transmission of P. falciparum.
KW - Bone marrow
KW - Gametocytes
KW - Malaria
KW - Plasmodium transmission
KW - Stromal microenvironment
UR - http://www.scopus.com/inward/record.url?scp=85020313606&partnerID=8YFLogxK
UR - http://www.scopus.com/inward/citedby.url?scp=85020313606&partnerID=8YFLogxK
U2 - 10.4415/ANN_17_02_03
DO - 10.4415/ANN_17_02_03
M3 - Review article
AN - SCOPUS:85020313606
VL - 53
SP - 96
EP - 99
JO - Annali dell'Istituto Superiore di Sanita
JF - Annali dell'Istituto Superiore di Sanita
SN - 0021-2571
IS - 2
ER -