The emerging role of trans-oral robotic surgery for the detection of the primary tumour site in patients with head-neck unknown primary cancers: A meta-analysis

Giuseppe Meccariello, Giovanni Cammaroto, Enyinnaya Ofo, Sebastiano Calpona, Elisabetta Parisi, Giovanni D'Agostino, Riccardo Gobbi, Elisabetta Firinu, Chiara Bellini, Andrea De Vito, Filippo Montevecchi, Matteo Costantini, Elena Amadori, Simona Nuzzo, Stefano Pelucchi, Claudio Vicini

Research output: Contribution to journalReview articlepeer-review

Abstract

The identification of the site in head neck unknown primary (HNUP) tumour is of utmost importance to help select best treatment while decreasing treatment-related morbidity and mortality. The primary purpose of this study is to demonstrate that TORS may be a valuable tool in detecting primary tumour. Studies were systematically searched in the PubMed, EMBASE, the Cochrane Library and CENTRAL electronic databases. A total of 12 selected studies (349 patients) were analyzed. The primary tumour detection and positive surgical margins rates were 70.8% and 19.4%, respectively. The rate of HPV-related tumour was 71.3%. The primary tumour was mainly in base of tongue (64%). In conclusion, TORS seems to be an effective surgical approach both in terms of detection of primary tumour site and in terms of therapeutic perspective for HNUP. In particular, a subset of HPV-related tumours might benefits all advantages from this surgical modality.

Original languageEnglish
Pages (from-to)663-671
Number of pages9
JournalAuris Nasus Larynx
Volume46
Issue number5
DOIs
Publication statusPublished - Oct 2019

Keywords

  • Head neck
  • Lymph nodes
  • Robotic
  • Surgical procedures
  • Unknown primary tumors

ASJC Scopus subject areas

  • Surgery
  • Otorhinolaryngology

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