The endocannabinoid system in gp120-mediated insults and HIV-associated dementia

Monica Bari, Cinzia Rapino, Pamela Mozetic, Mauro Maccarrone

Research output: Contribution to journalArticlepeer-review

Abstract

Endocannabinoids (eCBs) include a group of lipid mediators that act as endogenous agonists at cannabinoid (CB1, CB2) and vanilloid (TRPV1) receptors. In the last two decades a number of eCBs-metabolizing enzymes have been discovered that, together with eCBs and congeners, target receptors and proteins responsible for their transport and intracellular trafficking form the so-called "endocannabinoid system" (ECS). Within the central nervous system ECS elements participate in neuroprotection against neuroinflammatory/neurodegenerative diseases like Alzheimer's disease, Parkinson's disease, Huntington's disease, amyotrophic lateral sclerosis, and multiple sclerosis. More recently, a role for eCBs has been documented also in human immunodeficiency virus-1 (HIV-1) envelope glycoprotein gp120-mediated insults, and in HIV-associated dementia (HAD). The modulation of ECS in the latter disease conditions is the subject of this review, that will also address the molecular mechanisms underlying the neuroprotective effects of eCBs. In particular, the interactions between neurons and glia during neuroinflammation, and the alterations of ECS in these cells upon gp120 insults and HAD will be discussed, along with the potential therapeutic exploitation of ECS-oriented drugs for the treatment of HAD and related disorders.

Original languageEnglish
Pages (from-to)74-84
Number of pages11
JournalExperimental Neurology
Volume224
Issue number1
DOIs
Publication statusPublished - Jul 2010

Keywords

  • Cytokines
  • Endocannabinoids
  • Glia
  • Gp120
  • HAD
  • HIV-1
  • Immune surveillance
  • Neuroinflammation
  • Neuroprotection
  • Signal transduction

ASJC Scopus subject areas

  • Developmental Neuroscience
  • Neurology

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