The endocrine cells of the pancreas and related tumours - Ultrastructural study and classification

C. Capella, E. Solcia, B. Frigerio, R. Buffa, L. Usellini, P. Fontana

Research output: Contribution to journalArticle

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Abstract

Up to seven endocrine cell types have been identified ultrastructurally in the pancreas, including glucagon A cells, insulin B cells, somatostatin D cells, pancreatic peptide F cells and 5-hydroxytryptamine EC cells. In addition, D1 cells, which have been proposed as the cell type producing VIP and possible P cells of unknown function are seen. Various patterns of endocrine cell differentiation have been found in 20 endocrine pancreatic tumours. Well and poorly differentiated B cells have been identified in 6 insulinomas, diagnostic G cells in 3 out of 7 gastrinomas, D1 and/or F cells in 7 diarrheogenic tumours. Moreover, cells apparently unrelated to the prevalent clinical syndrome have been noted in 8 of the 20 tumours. Granular non diagnostic cells (poorly diagnostic gastrin cells? D1 cells?) were particularly frequent in gastrinomas; agranular or poorly granular cells, either of "active" or "stem cell" type, were present in nearly all tumours, particularly in diarrheogenic tumours, gastrinomas and malignant insulinomas. A cytological classification of pancreatic endocrine tumours is proposed.

Original languageEnglish
Pages (from-to)327-352
Number of pages26
JournalVirchows Archiv A Pathological Anatomy and Histology
Volume373
Issue number4
DOIs
Publication statusPublished - Dec 1977

Fingerprint

Endocrine Cells
Islets of Langerhans
Neoplasms
Gastrinoma
Vipoma
Gastrin-Secreting Cells
Insulinoma
Somatostatin-Secreting Cells
B-Lymphocytes
Glucagon
Cell Differentiation
Pancreas
Serotonin
Stem Cells
Insulin

Keywords

  • Gastrinomas
  • Insulinomas
  • Pancreatic endocrine cells
  • Ultrastructure
  • WDHA tumours

ASJC Scopus subject areas

  • Pathology and Forensic Medicine
  • Histology
  • Anatomy
  • Medicine(all)

Cite this

The endocrine cells of the pancreas and related tumours - Ultrastructural study and classification. / Capella, C.; Solcia, E.; Frigerio, B.; Buffa, R.; Usellini, L.; Fontana, P.

In: Virchows Archiv A Pathological Anatomy and Histology, Vol. 373, No. 4, 12.1977, p. 327-352.

Research output: Contribution to journalArticle

Capella, C. ; Solcia, E. ; Frigerio, B. ; Buffa, R. ; Usellini, L. ; Fontana, P. / The endocrine cells of the pancreas and related tumours - Ultrastructural study and classification. In: Virchows Archiv A Pathological Anatomy and Histology. 1977 ; Vol. 373, No. 4. pp. 327-352.
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