The endocrine component of prostatic carcinomas, mixed adenocarcinoma-carcinoid tumors and non-tumor prostate. Histochemical and ultrastructural identification of the endocrine cells

C. Capella, L. Usellini, R. Buffa, B. Frigerio, E. Solcia

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Two types of endocrine-paracrine (EP) cells have been detected histochemically and ultrastructurally in normal and hyperplastic prostates; i.e., type 1 cells resembling intestinal EC (enterochromaffin) cells and type 2 cells similar to urethral EP cells previously reported by Casanova et al. (1974). About one-third of the 40 prostatic carcinomas studied contained EP cells. Four tumors showed a very large number of EP cells: two of these were composite tumors exhibiting both adenocarcinomatous and carcinoid patterns. These four tumors have also been studied histochemically and ultrastructurally. ACTH and β-endorphin immunoreactive cells, ultrastructurally resembling pituitary corticotrophic cells, have been identified in three tumors. Cells identical with type 1 and type 2 cells of the normal prostate were detected in two cases and in a further case, respectively.

Original languageEnglish
Pages (from-to)175-192
Number of pages18
Issue number2
Publication statusPublished - 1981


ASJC Scopus subject areas

  • Anatomy
  • Pathology and Forensic Medicine
  • Cell Biology

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