Abstract
Bone is a peculiar tissue subjected to a continuous process of self-renewal essential to assure the integrity of the skeleton and to explicate the endocrine functions. The study of bone diseases characterized by increased or reduced bone mass due to osteoclast alterations has been essential to understand the great role played by osteocalcin in the endocrine functions of the skeleton. The ability of osteoclasts to regulate the decarboxylation of osteocalcin and to control glucose metabolism, male fertility, and cognitive functions was demonstrated by the use of animal models. In this review we described how diseases characterized by defective and increased bone resorption activity, as osteopetrosis and osteoporosis, were essential to understand the involvement of bone tissue in whole body physiology. To translate this knowledge into humans, recently published reports on patients were described, but further studies should be performed to confirm this complex hormonal regulation in humans.
| Original language | English |
|---|---|
| Journal | International Journal of Molecular Sciences |
| Volume | 20 |
| Issue number | 18 |
| DOIs | |
| Publication status | Published - Sep 11 2019 |
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The Endocrine Function of Osteocalcin Regulated by Bone Resorption : A Lesson from Reduced and Increased Bone Mass Diseases. / Rossi, Michela; Battafarano, Giulia; Pepe, Jessica; Minisola, Salvatore; Del Fattore, Andrea.
In: International Journal of Molecular Sciences, Vol. 20, No. 18, 11.09.2019.Research output: Contribution to journal › Review article
}
TY - JOUR
T1 - The Endocrine Function of Osteocalcin Regulated by Bone Resorption
T2 - A Lesson from Reduced and Increased Bone Mass Diseases
AU - Rossi, Michela
AU - Battafarano, Giulia
AU - Pepe, Jessica
AU - Minisola, Salvatore
AU - Del Fattore, Andrea
PY - 2019/9/11
Y1 - 2019/9/11
N2 - Bone is a peculiar tissue subjected to a continuous process of self-renewal essential to assure the integrity of the skeleton and to explicate the endocrine functions. The study of bone diseases characterized by increased or reduced bone mass due to osteoclast alterations has been essential to understand the great role played by osteocalcin in the endocrine functions of the skeleton. The ability of osteoclasts to regulate the decarboxylation of osteocalcin and to control glucose metabolism, male fertility, and cognitive functions was demonstrated by the use of animal models. In this review we described how diseases characterized by defective and increased bone resorption activity, as osteopetrosis and osteoporosis, were essential to understand the involvement of bone tissue in whole body physiology. To translate this knowledge into humans, recently published reports on patients were described, but further studies should be performed to confirm this complex hormonal regulation in humans.
AB - Bone is a peculiar tissue subjected to a continuous process of self-renewal essential to assure the integrity of the skeleton and to explicate the endocrine functions. The study of bone diseases characterized by increased or reduced bone mass due to osteoclast alterations has been essential to understand the great role played by osteocalcin in the endocrine functions of the skeleton. The ability of osteoclasts to regulate the decarboxylation of osteocalcin and to control glucose metabolism, male fertility, and cognitive functions was demonstrated by the use of animal models. In this review we described how diseases characterized by defective and increased bone resorption activity, as osteopetrosis and osteoporosis, were essential to understand the involvement of bone tissue in whole body physiology. To translate this knowledge into humans, recently published reports on patients were described, but further studies should be performed to confirm this complex hormonal regulation in humans.
U2 - 10.3390/ijms20184502
DO - 10.3390/ijms20184502
M3 - Review article
C2 - 31514440
VL - 20
JO - International Journal of Molecular Sciences
JF - International Journal of Molecular Sciences
SN - 1661-6596
IS - 18
ER -