The endocrine role for chromogranin A: A prohormone for peptides with regulatory properties

K. B. Helle, A. Corti, M. H. Metz-Boutigue, B. Tota

Research output: Contribution to journalArticle

Abstract

Chromogranin A (CgA) belongs to the granin family of uniquely acidic secretory proteins co-stored and co-secreted with other hormones and peptides in elements of the diffuse neuroendocrine system. The granins arise from different genes and are characterized by numerous sites for post-translational cleavage into shorter peptides with postulated regulatory properties. This review is directed towards endocrine aspects of CgA and its biologically active peptides. There is ample evidence from in vitro studies of distinct effects and targets for three CgA-derived peptides, vasostatin-I, pancreastatin and catestatin. Endocrine regulations are indicated from in vivo studies, consistent with the postulated prohormone function of CgA for peptides with regulatory properties. Most of the effects fit into patterns of direct or indirect, inhibitory modulations of major functions, implicating CgA peptides in regulation of calcium and glucose metabolism, cardiovascular functions, gastrointestinal motility and nociception, tissue repair, inflammatory responses and as host defense peptides in the first phase of microbial invasions.

Original languageEnglish
Pages (from-to)2863-2886
Number of pages24
JournalCellular and Molecular Life Sciences
Volume64
Issue number22
DOIs
Publication statusPublished - Nov 2007

Keywords

  • Calcium and glucose metabolism
  • Cateslytin
  • Catestatin
  • CgA peptides
  • Chromofungin
  • Pancreastatin
  • Parastatin
  • Vasostatins

ASJC Scopus subject areas

  • Biochemistry, Genetics and Molecular Biology(all)
  • Cell Biology

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