The endocytic matrix

Giorgio Scita, Pier Paolo Di Fiore

Research output: Contribution to journalArticle

321 Citations (Scopus)

Abstract

Endocytosis has long been thought of as simply a way for cells to internalize nutrients and membrane-associated molecules. But an explosive growth in knowledge has given a new dimension to our understanding of this process. It now seems that endocytosis is a master organizer of signalling circuits, with one of its main roles being the resolution of signals in space and time. Many of the functions of endocytosis that are emerging from recent research cannot yet be reconciled with the canonical view of intracellular trafficking but, instead, point to endocytosis being integrated at a deeper level in the cellular 'master plan' (the cellular network of signalling circuits that lie at the base of the cell's make-up). Deconvolution of this level, which we call the 'endocytic matrix', might uncover a fundamental aspect of how a cell is built.

Original languageEnglish
Pages (from-to)464-473
Number of pages10
JournalNature
Volume463
Issue number7280
DOIs
Publication statusPublished - Jan 28 2010

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Endocytosis
Food
Membranes
Growth
Research

ASJC Scopus subject areas

  • General

Cite this

The endocytic matrix. / Scita, Giorgio; Di Fiore, Pier Paolo.

In: Nature, Vol. 463, No. 7280, 28.01.2010, p. 464-473.

Research output: Contribution to journalArticle

Scita, G & Di Fiore, PP 2010, 'The endocytic matrix', Nature, vol. 463, no. 7280, pp. 464-473. https://doi.org/10.1038/nature08910
Scita, Giorgio ; Di Fiore, Pier Paolo. / The endocytic matrix. In: Nature. 2010 ; Vol. 463, No. 7280. pp. 464-473.
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