TY - JOUR
T1 - The endothelin axis
T2 - Emerging role in cancer
AU - Nelson, Joel
AU - Bagnato, Anna
AU - Battistini, Bruno
AU - Nisen, Perry
PY - 2003/2
Y1 - 2003/2
N2 - Collectively, the endothelins and their receptors - referred to as the endothelin (ET) axis - have key physiological functions in normal tissue, acting as modulators of vasomotor tone, tissue differentiation, development, cell proliferation and hormone production. Based on new data, the ET axis also functions in the growth and progression of various tumours. Preliminary results from clinical trials, such as those with atrasentan - an ETA -receptor antagonist - in prostate cancer, are encouraging. The place of ET-receptor antagonists in cancer therapy for a range of malignancies merits further investigation.
AB - Collectively, the endothelins and their receptors - referred to as the endothelin (ET) axis - have key physiological functions in normal tissue, acting as modulators of vasomotor tone, tissue differentiation, development, cell proliferation and hormone production. Based on new data, the ET axis also functions in the growth and progression of various tumours. Preliminary results from clinical trials, such as those with atrasentan - an ETA -receptor antagonist - in prostate cancer, are encouraging. The place of ET-receptor antagonists in cancer therapy for a range of malignancies merits further investigation.
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U2 - 10.1038/nrc990
DO - 10.1038/nrc990
M3 - Article
C2 - 12563310
AN - SCOPUS:0037317520
VL - 3
SP - 110
EP - 116
JO - Nature Reviews Cancer
JF - Nature Reviews Cancer
SN - 1474-175X
IS - 2
ER -