The endothelin axis: Emerging role in cancer

Joel Nelson, Anna Bagnato, Bruno Battistini, Perry Nisen

Research output: Contribution to journalArticlepeer-review


Collectively, the endothelins and their receptors - referred to as the endothelin (ET) axis - have key physiological functions in normal tissue, acting as modulators of vasomotor tone, tissue differentiation, development, cell proliferation and hormone production. Based on new data, the ET axis also functions in the growth and progression of various tumours. Preliminary results from clinical trials, such as those with atrasentan - an ETA -receptor antagonist - in prostate cancer, are encouraging. The place of ET-receptor antagonists in cancer therapy for a range of malignancies merits further investigation.

Original languageEnglish
Pages (from-to)110-116
Number of pages7
JournalNature Reviews Cancer
Issue number2
Publication statusPublished - Feb 2003

ASJC Scopus subject areas

  • Cancer Research


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