The enemy within. How to identify chronic diseases induced-protein metabolism impairment and its possible pharmacological treatment

Evasio Pasini, Roberto Aquilani, Francesco Saverio Dioguardi

Research output: Contribution to journalArticle


Recent clinical and experimental data show that considerable impairment of protein metabolism occurs in patients with chronic diseases such as heart failure. However, too often the extent of impairment is under-estimated or ignored by most clinicians and no therapy is considered leading to progressive loss of body proteins, increase morbidity, hospital stay and mortality. This paper illustrates the possible biological markers to evaluate general protein metabolism, including quantification of related damage and possible improvement of the metabolism using specific therapeutical metabolic strategies recently studied in a clinical setting.

Original languageEnglish
Pages (from-to)28-33
Number of pages6
JournalPharmacological Research
Publication statusPublished - 2013



  • Amino acid
  • Chronic diseases
  • Nutrition
  • Protein metabolism
  • Rehabilitation
  • Sarcopenia

ASJC Scopus subject areas

  • Pharmacology

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