The enemy within. How to identify chronic diseases induced-protein metabolism impairment and its possible pharmacological treatment

Evasio Pasini, Roberto Aquilani, Francesco Saverio Dioguardi

Research output: Contribution to journalArticle

4 Citations (Scopus)

Abstract

Recent clinical and experimental data show that considerable impairment of protein metabolism occurs in patients with chronic diseases such as heart failure. However, too often the extent of impairment is under-estimated or ignored by most clinicians and no therapy is considered leading to progressive loss of body proteins, increase morbidity, hospital stay and mortality. This paper illustrates the possible biological markers to evaluate general protein metabolism, including quantification of related damage and possible improvement of the metabolism using specific therapeutical metabolic strategies recently studied in a clinical setting.

Original languageEnglish
Pages (from-to)28-33
Number of pages6
JournalPharmacological Research
Volume76
DOIs
Publication statusPublished - 2013

Fingerprint

Chronic Disease
Pharmacology
Proteins
Hospital Mortality
Length of Stay
Therapeutics
Heart Failure
Biomarkers
Morbidity

Keywords

  • Amino acid
  • Chronic diseases
  • Nutrition
  • Protein metabolism
  • Rehabilitation
  • Sarcopenia

ASJC Scopus subject areas

  • Pharmacology

Cite this

The enemy within. How to identify chronic diseases induced-protein metabolism impairment and its possible pharmacological treatment. / Pasini, Evasio; Aquilani, Roberto; Dioguardi, Francesco Saverio.

In: Pharmacological Research, Vol. 76, 2013, p. 28-33.

Research output: Contribution to journalArticle

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