The epidemiology of amyotrophic lateral sclerosis in the Mount Etna region: A possible pathogenic role of volcanogenic metals

A. Nicoletti, R. Vasta, V. Venti, G. Mostile, S. Lo Fermo, F. Patti, R. Scillieri, D. De Cicco, P. Volanti, R. Marziolo, D. Maimone, M. Fiore, M. Ferrante, M. Zappia

Research output: Contribution to journalArticle

Abstract

Background and purpose: Trace elements (TEs) may play a role in the pathogenesis of amyotrophic lateral sclerosis (ALS) and volcanic degassing is the major natural source of TEs. Mount Etna, in the province of Catania, is the largest active volcano in Europe. Our aim was to assess the incidence of ALS in the province of Catania during 2005-2010 and its spatial distribution with respect to volcanic gas deposition. Methods: Cases from all neurological centres of the province of Catania and of the boundary provinces were retrospectively collected. Patients who had onset during 2005-2010 and fulfilled the El Escorial revised diagnostic criteria were included. The incidence of ALS was estimated for the entire province and separately for the population living on the eastern and western flank of Mount Etna, respectively, the most and least exposed areas to volcanogenic TEs, considered as a possible risk factor for ALS. Results: One hundred and twenty-six (57 men) ALS patients were enrolled. The mean annual crude incidence rate was 2.0/100 000 person-years (95% confidence interval 1.7-2.4). A higher incidence rate was found in the population living on the eastern flank compared to the western flank (2.4/100 000 and 0.9/100 000 respectively) with a relative risk of 2.75 (95% confidence interval 1.64-4.89; P <0.001). Conclusions: The incidence of ALS in the province of Catania is close to those reported worldwide. The incidence was higher amongst the population living on the eastern flank of Mount Etna, which could be interpreted as a possible role of volcanogenic TEs. Further research on TEs and genetic factors is necessary to support this assumption.

Original languageEnglish
Pages (from-to)964-972
Number of pages9
JournalEuropean Journal of Neurology
Volume23
Issue number5
DOIs
Publication statusPublished - May 1 2016

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Amyotrophic Lateral Sclerosis
Trace Elements
Epidemiology
Metals
Incidence
Volcanic Eruptions
Confidence Intervals
Population
Research

Keywords

  • Amyotrophic lateral sclerosis
  • Neuroepidemiology

ASJC Scopus subject areas

  • Clinical Neurology
  • Neurology

Cite this

The epidemiology of amyotrophic lateral sclerosis in the Mount Etna region : A possible pathogenic role of volcanogenic metals. / Nicoletti, A.; Vasta, R.; Venti, V.; Mostile, G.; Lo Fermo, S.; Patti, F.; Scillieri, R.; De Cicco, D.; Volanti, P.; Marziolo, R.; Maimone, D.; Fiore, M.; Ferrante, M.; Zappia, M.

In: European Journal of Neurology, Vol. 23, No. 5, 01.05.2016, p. 964-972.

Research output: Contribution to journalArticle

Nicoletti, A, Vasta, R, Venti, V, Mostile, G, Lo Fermo, S, Patti, F, Scillieri, R, De Cicco, D, Volanti, P, Marziolo, R, Maimone, D, Fiore, M, Ferrante, M & Zappia, M 2016, 'The epidemiology of amyotrophic lateral sclerosis in the Mount Etna region: A possible pathogenic role of volcanogenic metals', European Journal of Neurology, vol. 23, no. 5, pp. 964-972. https://doi.org/10.1111/ene.12973
Nicoletti, A. ; Vasta, R. ; Venti, V. ; Mostile, G. ; Lo Fermo, S. ; Patti, F. ; Scillieri, R. ; De Cicco, D. ; Volanti, P. ; Marziolo, R. ; Maimone, D. ; Fiore, M. ; Ferrante, M. ; Zappia, M. / The epidemiology of amyotrophic lateral sclerosis in the Mount Etna region : A possible pathogenic role of volcanogenic metals. In: European Journal of Neurology. 2016 ; Vol. 23, No. 5. pp. 964-972.
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abstract = "Background and purpose: Trace elements (TEs) may play a role in the pathogenesis of amyotrophic lateral sclerosis (ALS) and volcanic degassing is the major natural source of TEs. Mount Etna, in the province of Catania, is the largest active volcano in Europe. Our aim was to assess the incidence of ALS in the province of Catania during 2005-2010 and its spatial distribution with respect to volcanic gas deposition. Methods: Cases from all neurological centres of the province of Catania and of the boundary provinces were retrospectively collected. Patients who had onset during 2005-2010 and fulfilled the El Escorial revised diagnostic criteria were included. The incidence of ALS was estimated for the entire province and separately for the population living on the eastern and western flank of Mount Etna, respectively, the most and least exposed areas to volcanogenic TEs, considered as a possible risk factor for ALS. Results: One hundred and twenty-six (57 men) ALS patients were enrolled. The mean annual crude incidence rate was 2.0/100 000 person-years (95{\%} confidence interval 1.7-2.4). A higher incidence rate was found in the population living on the eastern flank compared to the western flank (2.4/100 000 and 0.9/100 000 respectively) with a relative risk of 2.75 (95{\%} confidence interval 1.64-4.89; P <0.001). Conclusions: The incidence of ALS in the province of Catania is close to those reported worldwide. The incidence was higher amongst the population living on the eastern flank of Mount Etna, which could be interpreted as a possible role of volcanogenic TEs. Further research on TEs and genetic factors is necessary to support this assumption.",
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T1 - The epidemiology of amyotrophic lateral sclerosis in the Mount Etna region

T2 - A possible pathogenic role of volcanogenic metals

AU - Nicoletti, A.

AU - Vasta, R.

AU - Venti, V.

AU - Mostile, G.

AU - Lo Fermo, S.

AU - Patti, F.

AU - Scillieri, R.

AU - De Cicco, D.

AU - Volanti, P.

AU - Marziolo, R.

AU - Maimone, D.

AU - Fiore, M.

AU - Ferrante, M.

AU - Zappia, M.

PY - 2016/5/1

Y1 - 2016/5/1

N2 - Background and purpose: Trace elements (TEs) may play a role in the pathogenesis of amyotrophic lateral sclerosis (ALS) and volcanic degassing is the major natural source of TEs. Mount Etna, in the province of Catania, is the largest active volcano in Europe. Our aim was to assess the incidence of ALS in the province of Catania during 2005-2010 and its spatial distribution with respect to volcanic gas deposition. Methods: Cases from all neurological centres of the province of Catania and of the boundary provinces were retrospectively collected. Patients who had onset during 2005-2010 and fulfilled the El Escorial revised diagnostic criteria were included. The incidence of ALS was estimated for the entire province and separately for the population living on the eastern and western flank of Mount Etna, respectively, the most and least exposed areas to volcanogenic TEs, considered as a possible risk factor for ALS. Results: One hundred and twenty-six (57 men) ALS patients were enrolled. The mean annual crude incidence rate was 2.0/100 000 person-years (95% confidence interval 1.7-2.4). A higher incidence rate was found in the population living on the eastern flank compared to the western flank (2.4/100 000 and 0.9/100 000 respectively) with a relative risk of 2.75 (95% confidence interval 1.64-4.89; P <0.001). Conclusions: The incidence of ALS in the province of Catania is close to those reported worldwide. The incidence was higher amongst the population living on the eastern flank of Mount Etna, which could be interpreted as a possible role of volcanogenic TEs. Further research on TEs and genetic factors is necessary to support this assumption.

AB - Background and purpose: Trace elements (TEs) may play a role in the pathogenesis of amyotrophic lateral sclerosis (ALS) and volcanic degassing is the major natural source of TEs. Mount Etna, in the province of Catania, is the largest active volcano in Europe. Our aim was to assess the incidence of ALS in the province of Catania during 2005-2010 and its spatial distribution with respect to volcanic gas deposition. Methods: Cases from all neurological centres of the province of Catania and of the boundary provinces were retrospectively collected. Patients who had onset during 2005-2010 and fulfilled the El Escorial revised diagnostic criteria were included. The incidence of ALS was estimated for the entire province and separately for the population living on the eastern and western flank of Mount Etna, respectively, the most and least exposed areas to volcanogenic TEs, considered as a possible risk factor for ALS. Results: One hundred and twenty-six (57 men) ALS patients were enrolled. The mean annual crude incidence rate was 2.0/100 000 person-years (95% confidence interval 1.7-2.4). A higher incidence rate was found in the population living on the eastern flank compared to the western flank (2.4/100 000 and 0.9/100 000 respectively) with a relative risk of 2.75 (95% confidence interval 1.64-4.89; P <0.001). Conclusions: The incidence of ALS in the province of Catania is close to those reported worldwide. The incidence was higher amongst the population living on the eastern flank of Mount Etna, which could be interpreted as a possible role of volcanogenic TEs. Further research on TEs and genetic factors is necessary to support this assumption.

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