The epidemiology of malignant mesothelioma in women

Alessandro Marinaccio, Marisa Corfiati, Alessandra Binazzi, Davide Di Marzio, Alberto Scarselli, Pierpaolo Ferrante, Michela Bonafede, Marina Verardo, Dario Mirabelli, Valerio Gennaro, Carolina Mensi, Gert Schallemberg, Guido Mazzoleni, Enzo Merler, Paolo Girardi, Corrado Negro, Flavia D'Agostin, Antonio Romanelli, Elisabetta Chellini, Stefano SilvestriCristiana Pascucci, Roberto Calisti, Fabrizio Stracci, Elisa Romeo, Valeria Ascoli, Luana Trafficante, Francesco Carrozza, Italo Francesco Angelillo, Domenica Cavone, Gabriella Cauzillo, Federico Tallarigo, Rosario Tumino, Massimo Melis, Sergio Iavicoli, ReNaM Working Group, Lucia Mangone

Research output: Contribution to journalArticlepeer-review


INTRODUCTION: The epidemiology of gender differences for mesothelioma incidence has been rarely discussed in national case lists. In Italy an epidemiological surveillance system (ReNaM) is working by the means of a national register.METHODS: Incident malignant mesothelioma (MM) cases in the period 1993 to 2012 were retrieved from ReNaM. Gender ratio by age class, period of diagnosis, diagnostic certainty, morphology and modalities of asbestos exposure has been analysed using exact tests for proportion. Economic activity sectors, jobs and territorial distribution of mesothelioma cases in women have been described and discussed. To perform international comparative analyses, the gender ratio of mesothelioma deaths was calculated by country from the WHO database and the correlation with the mortality rates estimated.RESULTS: In the period of study a case list of 21 463 MMs has been registered and the modalities of asbestos exposure have been investigated for 16 458 (76.7%) of them. The gender ratio (F/M) was 0.38 and 0.70 (0.14 and 0.30 for occupationally exposed subjects only) for pleural and peritoneal cases respectively. Occupational exposures for female MM cases occurred in the chemical and plastic industry, and mainly in the non-asbestos textile sector. Gender ratio proved to be inversely correlated with mortality rate among countries.CONCLUSIONS: The consistent proportion of mesothelioma cases in women in Italy is mainly due to the relevant role of non-occupational asbestos exposures and the historical presence of the female workforce in several industrial settings. Enhancing the awareness of mesothelioma aetiology in women could support the effectiveness of welfare system and prevention policies.
Original languageEnglish
JournalOccupational and Environmental Medicine
Publication statusPublished - Dec 21 2017


  • Journal Article


Dive into the research topics of 'The epidemiology of malignant mesothelioma in women'. Together they form a unique fingerprint.

Cite this