The epidemiology of malignant mesothelioma in women: Gender differences and modalities of asbestos exposure

ReNaM Working Group

Research output: Contribution to journalArticle

13 Citations (Scopus)

Abstract

Introduction The epidemiology of gender differences for mesothelioma incidence has been rarely discussed in national case lists. In Italy an epidemiological surveillance system (ReNaM) is working by the means of a national register. Methods Incident malignant mesothelioma (MM) cases in the period 1993 to 2012 were retrieved from ReNaM. Gender ratio by age class, period of diagnosis, diagnostic certainty, morphology and modalities of asbestos exposure has been analysed using exact tests for proportion. Economic activity sectors, jobs and territorial distribution of mesothelioma cases in women have been described and discussed. To perform international comparative analyses, the gender ratio of mesothelioma deaths was calculated by country from the WHO database and the correlation with the mortality rates estimated. Results In the period of study a case list of 21 463 MMs has been registered and the modalities of asbestos exposure have been investigated for 16 458 (76.7%) of them. The gender ratio (F/M) was 0.38 and 0.70 (0.14 and 0.30 for occupationally exposed subjects only) for pleural and peritoneal cases respectively. Occupational exposures for female MM cases occurred in the chemical and plastic industry, and mainly in the non-asbestos textile sector. Gender ratio proved to be inversely correlated with mortality rate among countries. Conclusions The consistent proportion of mesothelioma cases in women in Italy is mainly due to the relevant role of non-occupational asbestos exposures and the historical presence of the female workforce in several industrial settings. Enhancing the awareness of mesothelioma aetiology in women could support the effectiveness of welfare system and prevention policies.

Original languageEnglish
Pages (from-to)254-262
Number of pages9
JournalOccupational and Environmental Medicine
Volume75
Issue number4
DOIs
Publication statusPublished - Apr 1 2018

Fingerprint

Asbestos
Mesothelioma
Epidemiology
Italy
Chemical Industry
Mortality
Textiles
Occupational Exposure
Plastics
Economics
Malignant Mesothelioma
Databases
Incidence

Keywords

  • asbestos
  • gender
  • mesothelioma

ASJC Scopus subject areas

  • Public Health, Environmental and Occupational Health

Cite this

The epidemiology of malignant mesothelioma in women : Gender differences and modalities of asbestos exposure. / ReNaM Working Group.

In: Occupational and Environmental Medicine, Vol. 75, No. 4, 01.04.2018, p. 254-262.

Research output: Contribution to journalArticle

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abstract = "Introduction The epidemiology of gender differences for mesothelioma incidence has been rarely discussed in national case lists. In Italy an epidemiological surveillance system (ReNaM) is working by the means of a national register. Methods Incident malignant mesothelioma (MM) cases in the period 1993 to 2012 were retrieved from ReNaM. Gender ratio by age class, period of diagnosis, diagnostic certainty, morphology and modalities of asbestos exposure has been analysed using exact tests for proportion. Economic activity sectors, jobs and territorial distribution of mesothelioma cases in women have been described and discussed. To perform international comparative analyses, the gender ratio of mesothelioma deaths was calculated by country from the WHO database and the correlation with the mortality rates estimated. Results In the period of study a case list of 21 463 MMs has been registered and the modalities of asbestos exposure have been investigated for 16 458 (76.7{\%}) of them. The gender ratio (F/M) was 0.38 and 0.70 (0.14 and 0.30 for occupationally exposed subjects only) for pleural and peritoneal cases respectively. Occupational exposures for female MM cases occurred in the chemical and plastic industry, and mainly in the non-asbestos textile sector. Gender ratio proved to be inversely correlated with mortality rate among countries. Conclusions The consistent proportion of mesothelioma cases in women in Italy is mainly due to the relevant role of non-occupational asbestos exposures and the historical presence of the female workforce in several industrial settings. Enhancing the awareness of mesothelioma aetiology in women could support the effectiveness of welfare system and prevention policies.",
keywords = "asbestos, gender, mesothelioma",
author = "{ReNaM Working Group} and Alessandro Marinaccio and Marisa Corfiati and Alessandra Binazzi and {Di Marzio}, Davide and Alberto Scarselli and Pierpaolo Ferrante and Michela Bonafede and Marina Verardo and Dario Mirabelli and Valerio Gennaro and Carolina Mensi and Gert Schallemberg and Guido Mazzoleni and Enzo Merler and Paolo Girardi and Corrado Negro and Flavia D'Agostin and Antonio Romanelli and Elisabetta Chellini and Stefano Silvestri and Cristiana Pascucci and Roberto Calisti and Fabrizio Stracci and Elisa Romeo and Valeria Ascoli and Luana Trafficante and Francesco Carrozza and Angelillo, {Italo Francesco} and Domenica Cavone and Gabriella Cauzillo and Federico Tallarigo and Rosario Tumino and Massimo Melis and Sergio Iavicoli",
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T1 - The epidemiology of malignant mesothelioma in women

T2 - Gender differences and modalities of asbestos exposure

AU - ReNaM Working Group

AU - Marinaccio, Alessandro

AU - Corfiati, Marisa

AU - Binazzi, Alessandra

AU - Di Marzio, Davide

AU - Scarselli, Alberto

AU - Ferrante, Pierpaolo

AU - Bonafede, Michela

AU - Verardo, Marina

AU - Mirabelli, Dario

AU - Gennaro, Valerio

AU - Mensi, Carolina

AU - Schallemberg, Gert

AU - Mazzoleni, Guido

AU - Merler, Enzo

AU - Girardi, Paolo

AU - Negro, Corrado

AU - D'Agostin, Flavia

AU - Romanelli, Antonio

AU - Chellini, Elisabetta

AU - Silvestri, Stefano

AU - Pascucci, Cristiana

AU - Calisti, Roberto

AU - Stracci, Fabrizio

AU - Romeo, Elisa

AU - Ascoli, Valeria

AU - Trafficante, Luana

AU - Carrozza, Francesco

AU - Angelillo, Italo Francesco

AU - Cavone, Domenica

AU - Cauzillo, Gabriella

AU - Tallarigo, Federico

AU - Tumino, Rosario

AU - Melis, Massimo

AU - Iavicoli, Sergio

PY - 2018/4/1

Y1 - 2018/4/1

N2 - Introduction The epidemiology of gender differences for mesothelioma incidence has been rarely discussed in national case lists. In Italy an epidemiological surveillance system (ReNaM) is working by the means of a national register. Methods Incident malignant mesothelioma (MM) cases in the period 1993 to 2012 were retrieved from ReNaM. Gender ratio by age class, period of diagnosis, diagnostic certainty, morphology and modalities of asbestos exposure has been analysed using exact tests for proportion. Economic activity sectors, jobs and territorial distribution of mesothelioma cases in women have been described and discussed. To perform international comparative analyses, the gender ratio of mesothelioma deaths was calculated by country from the WHO database and the correlation with the mortality rates estimated. Results In the period of study a case list of 21 463 MMs has been registered and the modalities of asbestos exposure have been investigated for 16 458 (76.7%) of them. The gender ratio (F/M) was 0.38 and 0.70 (0.14 and 0.30 for occupationally exposed subjects only) for pleural and peritoneal cases respectively. Occupational exposures for female MM cases occurred in the chemical and plastic industry, and mainly in the non-asbestos textile sector. Gender ratio proved to be inversely correlated with mortality rate among countries. Conclusions The consistent proportion of mesothelioma cases in women in Italy is mainly due to the relevant role of non-occupational asbestos exposures and the historical presence of the female workforce in several industrial settings. Enhancing the awareness of mesothelioma aetiology in women could support the effectiveness of welfare system and prevention policies.

AB - Introduction The epidemiology of gender differences for mesothelioma incidence has been rarely discussed in national case lists. In Italy an epidemiological surveillance system (ReNaM) is working by the means of a national register. Methods Incident malignant mesothelioma (MM) cases in the period 1993 to 2012 were retrieved from ReNaM. Gender ratio by age class, period of diagnosis, diagnostic certainty, morphology and modalities of asbestos exposure has been analysed using exact tests for proportion. Economic activity sectors, jobs and territorial distribution of mesothelioma cases in women have been described and discussed. To perform international comparative analyses, the gender ratio of mesothelioma deaths was calculated by country from the WHO database and the correlation with the mortality rates estimated. Results In the period of study a case list of 21 463 MMs has been registered and the modalities of asbestos exposure have been investigated for 16 458 (76.7%) of them. The gender ratio (F/M) was 0.38 and 0.70 (0.14 and 0.30 for occupationally exposed subjects only) for pleural and peritoneal cases respectively. Occupational exposures for female MM cases occurred in the chemical and plastic industry, and mainly in the non-asbestos textile sector. Gender ratio proved to be inversely correlated with mortality rate among countries. Conclusions The consistent proportion of mesothelioma cases in women in Italy is mainly due to the relevant role of non-occupational asbestos exposures and the historical presence of the female workforce in several industrial settings. Enhancing the awareness of mesothelioma aetiology in women could support the effectiveness of welfare system and prevention policies.

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