The epidemiology of Varicella Zoster Virus infection in Italy

Giovanni Gabutti, Maria C. Rota, Marcello Guido, Antonella De Donno, Antonino Bella, Marta L. Ciofi Degli Atti, Pietro Crovari, D. Bassetti, A. Bechini, S. Boccalini, P. Bonanni, P. Caciagli, A. Camper, A. M. Campa, W. Caraccio, A. Cavallaro, E. Ciamarra, L. Clerico, [No Value] Casentino, E. De SimoneA. Favero, A. Focà, L. Genna, A. Giammanco, A. Giancotti, A. Goglio, S. Grandesso, G. C. Icardi, C. Lolli, D. Marchetti, M. Marsella, P. Martelli, L. Mucignat, D. Palladino, [No Value] Passerini, V. Perani, [No Value] Piscione, F. Rizza, M. C. Rollo, L. Simula, R. Sforza, D. Tagliatatela, M. Tronci, D. Villalta

Research output: Contribution to journalArticle

Abstract

Background. The epidemiological importance of varicella and zoster and the availability of an efficacious and safe vaccine have led to an important international debate regarding the suitability of mass vaccination. The objective of the study was to describe the epidemiology of varicella and zoster in Italy and to determine whether there have been changes with respect to observations provided by an analogous study conducted 8 years ago, in order to define the most appropriate vaccination strategy. Methods. A number of data sources were evaluated, a cross-sectional population-based seroprevalence study was conducted on samples collected in 2004, and the results were compared with data obtained in 1996. Results. The data from active and passive surveillance systems confirm that varicella is a widespread infectious disease which mainly affects children. VZV seroprevalence did not substantially differ from that found in the previous study. The sero-epidemiological profile in Italy is different from that in other European countries. In particular, the percentage of susceptible adolescents is at least nearly twice as high as in other European countries and in the age group 20-39 yrs, approximately 9% of individuals are susceptible to VZV. Conclusion. The results of this study can contribute to evaluating the options for varicella vaccination. It is possible that in a few years, in all Italian Regions, there will exist the conditions necessary for implementing a mass vaccination campaign and that the large-scale availability of MMRV tetravalent vaccines will facilitate mass vaccination.

Original languageEnglish
Article number372
JournalBMC Public Health
Volume8
DOIs
Publication statusPublished - 2008

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Human Herpesvirus 3
Chickenpox
Virus Diseases
Mass Vaccination
Italy
Epidemiology
Seroepidemiologic Studies
Herpes Zoster
Vaccination
Immunization Programs
Information Storage and Retrieval
Communicable Diseases
Vaccines
Age Groups
Population

ASJC Scopus subject areas

  • Public Health, Environmental and Occupational Health

Cite this

Gabutti, G., Rota, M. C., Guido, M., De Donno, A., Bella, A., Ciofi Degli Atti, M. L., ... Villalta, D. (2008). The epidemiology of Varicella Zoster Virus infection in Italy. BMC Public Health, 8, [372]. https://doi.org/10.1186/1471-2458-8-372

The epidemiology of Varicella Zoster Virus infection in Italy. / Gabutti, Giovanni; Rota, Maria C.; Guido, Marcello; De Donno, Antonella; Bella, Antonino; Ciofi Degli Atti, Marta L.; Crovari, Pietro; Bassetti, D.; Bechini, A.; Boccalini, S.; Bonanni, P.; Caciagli, P.; Camper, A.; Campa, A. M.; Caraccio, W.; Cavallaro, A.; Ciamarra, E.; Clerico, L.; Casentino, [No Value]; De Simone, E.; Favero, A.; Focà, A.; Genna, L.; Giammanco, A.; Giancotti, A.; Goglio, A.; Grandesso, S.; Icardi, G. C.; Lolli, C.; Marchetti, D.; Marsella, M.; Martelli, P.; Mucignat, L.; Palladino, D.; Passerini, [No Value]; Perani, V.; Piscione, [No Value]; Rizza, F.; Rollo, M. C.; Simula, L.; Sforza, R.; Tagliatatela, D.; Tronci, M.; Villalta, D.

In: BMC Public Health, Vol. 8, 372, 2008.

Research output: Contribution to journalArticle

Gabutti, G, Rota, MC, Guido, M, De Donno, A, Bella, A, Ciofi Degli Atti, ML, Crovari, P, Bassetti, D, Bechini, A, Boccalini, S, Bonanni, P, Caciagli, P, Camper, A, Campa, AM, Caraccio, W, Cavallaro, A, Ciamarra, E, Clerico, L, Casentino, NV, De Simone, E, Favero, A, Focà, A, Genna, L, Giammanco, A, Giancotti, A, Goglio, A, Grandesso, S, Icardi, GC, Lolli, C, Marchetti, D, Marsella, M, Martelli, P, Mucignat, L, Palladino, D, Passerini, NV, Perani, V, Piscione, NV, Rizza, F, Rollo, MC, Simula, L, Sforza, R, Tagliatatela, D, Tronci, M & Villalta, D 2008, 'The epidemiology of Varicella Zoster Virus infection in Italy', BMC Public Health, vol. 8, 372. https://doi.org/10.1186/1471-2458-8-372
Gabutti, Giovanni ; Rota, Maria C. ; Guido, Marcello ; De Donno, Antonella ; Bella, Antonino ; Ciofi Degli Atti, Marta L. ; Crovari, Pietro ; Bassetti, D. ; Bechini, A. ; Boccalini, S. ; Bonanni, P. ; Caciagli, P. ; Camper, A. ; Campa, A. M. ; Caraccio, W. ; Cavallaro, A. ; Ciamarra, E. ; Clerico, L. ; Casentino, [No Value] ; De Simone, E. ; Favero, A. ; Focà, A. ; Genna, L. ; Giammanco, A. ; Giancotti, A. ; Goglio, A. ; Grandesso, S. ; Icardi, G. C. ; Lolli, C. ; Marchetti, D. ; Marsella, M. ; Martelli, P. ; Mucignat, L. ; Palladino, D. ; Passerini, [No Value] ; Perani, V. ; Piscione, [No Value] ; Rizza, F. ; Rollo, M. C. ; Simula, L. ; Sforza, R. ; Tagliatatela, D. ; Tronci, M. ; Villalta, D. / The epidemiology of Varicella Zoster Virus infection in Italy. In: BMC Public Health. 2008 ; Vol. 8.
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title = "The epidemiology of Varicella Zoster Virus infection in Italy",
abstract = "Background. The epidemiological importance of varicella and zoster and the availability of an efficacious and safe vaccine have led to an important international debate regarding the suitability of mass vaccination. The objective of the study was to describe the epidemiology of varicella and zoster in Italy and to determine whether there have been changes with respect to observations provided by an analogous study conducted 8 years ago, in order to define the most appropriate vaccination strategy. Methods. A number of data sources were evaluated, a cross-sectional population-based seroprevalence study was conducted on samples collected in 2004, and the results were compared with data obtained in 1996. Results. The data from active and passive surveillance systems confirm that varicella is a widespread infectious disease which mainly affects children. VZV seroprevalence did not substantially differ from that found in the previous study. The sero-epidemiological profile in Italy is different from that in other European countries. In particular, the percentage of susceptible adolescents is at least nearly twice as high as in other European countries and in the age group 20-39 yrs, approximately 9{\%} of individuals are susceptible to VZV. Conclusion. The results of this study can contribute to evaluating the options for varicella vaccination. It is possible that in a few years, in all Italian Regions, there will exist the conditions necessary for implementing a mass vaccination campaign and that the large-scale availability of MMRV tetravalent vaccines will facilitate mass vaccination.",
author = "Giovanni Gabutti and Rota, {Maria C.} and Marcello Guido and {De Donno}, Antonella and Antonino Bella and {Ciofi Degli Atti}, {Marta L.} and Pietro Crovari and D. Bassetti and A. Bechini and S. Boccalini and P. Bonanni and P. Caciagli and A. Camper and Campa, {A. M.} and W. Caraccio and A. Cavallaro and E. Ciamarra and L. Clerico and Casentino, {[No Value]} and {De Simone}, E. and A. Favero and A. Foc{\`a} and L. Genna and A. Giammanco and A. Giancotti and A. Goglio and S. Grandesso and Icardi, {G. C.} and C. Lolli and D. Marchetti and M. Marsella and P. Martelli and L. Mucignat and D. Palladino and Passerini, {[No Value]} and V. Perani and Piscione, {[No Value]} and F. Rizza and Rollo, {M. C.} and L. Simula and R. Sforza and D. Tagliatatela and M. Tronci and D. Villalta",
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TY - JOUR

T1 - The epidemiology of Varicella Zoster Virus infection in Italy

AU - Gabutti, Giovanni

AU - Rota, Maria C.

AU - Guido, Marcello

AU - De Donno, Antonella

AU - Bella, Antonino

AU - Ciofi Degli Atti, Marta L.

AU - Crovari, Pietro

AU - Bassetti, D.

AU - Bechini, A.

AU - Boccalini, S.

AU - Bonanni, P.

AU - Caciagli, P.

AU - Camper, A.

AU - Campa, A. M.

AU - Caraccio, W.

AU - Cavallaro, A.

AU - Ciamarra, E.

AU - Clerico, L.

AU - Casentino, [No Value]

AU - De Simone, E.

AU - Favero, A.

AU - Focà, A.

AU - Genna, L.

AU - Giammanco, A.

AU - Giancotti, A.

AU - Goglio, A.

AU - Grandesso, S.

AU - Icardi, G. C.

AU - Lolli, C.

AU - Marchetti, D.

AU - Marsella, M.

AU - Martelli, P.

AU - Mucignat, L.

AU - Palladino, D.

AU - Passerini, [No Value]

AU - Perani, V.

AU - Piscione, [No Value]

AU - Rizza, F.

AU - Rollo, M. C.

AU - Simula, L.

AU - Sforza, R.

AU - Tagliatatela, D.

AU - Tronci, M.

AU - Villalta, D.

PY - 2008

Y1 - 2008

N2 - Background. The epidemiological importance of varicella and zoster and the availability of an efficacious and safe vaccine have led to an important international debate regarding the suitability of mass vaccination. The objective of the study was to describe the epidemiology of varicella and zoster in Italy and to determine whether there have been changes with respect to observations provided by an analogous study conducted 8 years ago, in order to define the most appropriate vaccination strategy. Methods. A number of data sources were evaluated, a cross-sectional population-based seroprevalence study was conducted on samples collected in 2004, and the results were compared with data obtained in 1996. Results. The data from active and passive surveillance systems confirm that varicella is a widespread infectious disease which mainly affects children. VZV seroprevalence did not substantially differ from that found in the previous study. The sero-epidemiological profile in Italy is different from that in other European countries. In particular, the percentage of susceptible adolescents is at least nearly twice as high as in other European countries and in the age group 20-39 yrs, approximately 9% of individuals are susceptible to VZV. Conclusion. The results of this study can contribute to evaluating the options for varicella vaccination. It is possible that in a few years, in all Italian Regions, there will exist the conditions necessary for implementing a mass vaccination campaign and that the large-scale availability of MMRV tetravalent vaccines will facilitate mass vaccination.

AB - Background. The epidemiological importance of varicella and zoster and the availability of an efficacious and safe vaccine have led to an important international debate regarding the suitability of mass vaccination. The objective of the study was to describe the epidemiology of varicella and zoster in Italy and to determine whether there have been changes with respect to observations provided by an analogous study conducted 8 years ago, in order to define the most appropriate vaccination strategy. Methods. A number of data sources were evaluated, a cross-sectional population-based seroprevalence study was conducted on samples collected in 2004, and the results were compared with data obtained in 1996. Results. The data from active and passive surveillance systems confirm that varicella is a widespread infectious disease which mainly affects children. VZV seroprevalence did not substantially differ from that found in the previous study. The sero-epidemiological profile in Italy is different from that in other European countries. In particular, the percentage of susceptible adolescents is at least nearly twice as high as in other European countries and in the age group 20-39 yrs, approximately 9% of individuals are susceptible to VZV. Conclusion. The results of this study can contribute to evaluating the options for varicella vaccination. It is possible that in a few years, in all Italian Regions, there will exist the conditions necessary for implementing a mass vaccination campaign and that the large-scale availability of MMRV tetravalent vaccines will facilitate mass vaccination.

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