Determinación genómica de virus de ebstein-barr en tumores del tracto aerodigestivo superior

Translated title of the contribution: The Epstein-Barr viral genome determination in upper aero-digestive tract tumors

José Gregorio Ponce, Henry Lares, Denise Mattar, María Correnti, Mayra Ávila

Research output: Contribution to journalArticlepeer-review


OBJECTIVE: The Epstein-Barr virus is been related with many malignancies as lymphoma and nasopharyngeal undifferentiated carcinoma. More recently, the presence of viral genome had been reported in some similar tumors how the lymphoepithelioma in other localizations for example the stomach, the liver, the breast and lung. METHODS: From January to June 2006, we had taken fresh from the patient's superior aero digestive tumors samples. The Epstein-Barr viral genome was determined by the Polymerasa Chain Reaction. RESULTADOS: From 41 samples of tumors, 18 were viruses positive and 23 of them were viruses negative. Thirteen malignant tumors were positive for the viruses genome and the rest ant other 48.1 % were negative. In eight larynxes, 4 nasopharyngeal, 2 piriform sinuses and some of this localization: nasal cavity, oral yugal mucosa, tonsil and maxillary sinus, and samples the viral genome of Epstein Barr was present. DISCUSION: Although, we had a limited number of sample in some regions mentioned in these work, we could determine the viral genome of Epstein Barr in some sites how larynx, nasal and oral cavity. The majority of malignant tumors were squamous cell carcinoma, only two of them were correspondent to lymphoepithelioma. CONCLUSION: The Epstein-Barr viral genome may be identified in fresh superior aero digestive tumors samples, like in squamous cell carcinoma of the larynx, the oral cavity, nasal cavity and in the pharynx. Further studies are necessary to identify the probability relation between this virus and these tumors.

Translated title of the contributionThe Epstein-Barr viral genome determination in upper aero-digestive tract tumors
Original languageSpanish
JournalRevista Venezolana de Oncologia
Issue number1
Publication statusPublished - Mar 2008


  • Carcinoma
  • Epstein-Barr
  • Head
  • Nasopharyngeal
  • Neck
  • Neoplasm
  • Virus

ASJC Scopus subject areas

  • Oncology


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