The equine herpesvirus 2 E1 open reading frame encodes a functional chemokine receptor

Grazia Camarda, Gaia Spinetti, Giovanni Bernardini, Catherine Mair, Nick Davis-Poynter, Maurizio C. Capogrossi, Monica Napolitano

Research output: Contribution to journalArticle

Abstract

Several herpesviruses contain open reading frames (ORFs) that encode potential homologs of eucaryotic genes. Equine herpesvirus 2 (EHV-2) is a gammaherpesvirus related to other lymphotropic herpesviruses such as herpesvirus saimiri and Epstein-Barr virus. The E1 ORF of EHV-2, a G protein- coupled receptor homolog, shows 31 to 47% amino acid identity with known CC chemokine receptors. To investigate whether E1 may encode a functional receptor, we cloned the E1 ORF and expressed it in stably transfected cell lines. We report here the identification of the CC chemokine eotaxin as a functional ligand for the EHV-2 E1 receptor. Chemokines are likely to play a role in the regulation of immune functions in equine hosts during EHV-2 infection and, via interaction with E1, may affect viral replication and/or escape from immune responses.

Original languageEnglish
Pages (from-to)9843-9848
Number of pages6
JournalJournal of Virology
Volume73
Issue number12
Publication statusPublished - Dec 1999

ASJC Scopus subject areas

  • Immunology

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    Camarda, G., Spinetti, G., Bernardini, G., Mair, C., Davis-Poynter, N., Capogrossi, M. C., & Napolitano, M. (1999). The equine herpesvirus 2 E1 open reading frame encodes a functional chemokine receptor. Journal of Virology, 73(12), 9843-9848.