The etiological role of blood-brain barrier dysfunction in seizure disorders

Nicola Marchi, William Tierney, Andreas V. Alexopoulos, Vikram Puvenna, Tiziana Granata, Damir Janigro

Research output: Contribution to journalArticlepeer-review


A wind of change characterizes epilepsy research efforts. The traditional approach, based on a neurocentric view of seizure generation, promoted understanding of the neuronal mechanisms of seizures; this resulted in the development of potent anti-epileptic drugs (AEDs). The fact that a significant number of individuals with epilepsy still fail to respond to available AEDs restates the need for an alternative approach. Blood-brain barrier (BBB) dysfunction is an important etiological player in seizure disorders, and combination therapies utilizing an AED in conjunction with a cerebrovascular drug could be used to control seizures more effectively than AED therapy alone. The fact that the BBB plays an etiologic role in other neurological diseases will be discussed in the context of a more holistic approach to the patient with epilepsy, where comorbidity variables are also encompassed by drug therapy.

Original languageEnglish
Article number482415
JournalCardiovascular Psychiatry and Neurology
Publication statusPublished - 2011

ASJC Scopus subject areas

  • Cardiology and Cardiovascular Medicine
  • Psychiatry and Mental health
  • Clinical Neurology
  • Neurology


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