The etiology mystery in primary biliary cirrhosis

Carlo Selmi, M. Eric Gershwin

Research output: Contribution to journalArticle

5 Citations (Scopus)

Abstract

The etiology of primary biliary cirrhosis remains largely unknown despite numerous lines of evidence that have been recently proposed or supported. Primary biliary cirrhosis is a chronic cholestatic liver disease for which an autoimmune pathogenesis is widely accepted, mostly based on the presence of autoantibodies and autoreactive T cells. Cumulatively, association and twin studies suggest that both a susceptible genetic background and environmental factors determine disease onset. Multiple infectious and chemical candidates may contribute to the disease onset in a genetically susceptible host. Several murine models have been recently reported and include genetically determined ones as well as models induced by immunization with chemicals and bacteria.

Original languageEnglish
Pages (from-to)105-115
Number of pages11
JournalDigestive Diseases
Volume28
Issue number1
DOIs
Publication statusPublished - May 2010

Fingerprint

Biliary Liver Cirrhosis
Twin Studies
Autoantibodies
Liver Diseases
Immunization
Bacteria
T-Lymphocytes
Genetic Background

Keywords

  • Antimitochondrial autoantibodies
  • Female predominance
  • Primary biliary cirrhosis

ASJC Scopus subject areas

  • Gastroenterology

Cite this

The etiology mystery in primary biliary cirrhosis. / Selmi, Carlo; Gershwin, M. Eric.

In: Digestive Diseases, Vol. 28, No. 1, 05.2010, p. 105-115.

Research output: Contribution to journalArticle

Selmi, Carlo ; Gershwin, M. Eric. / The etiology mystery in primary biliary cirrhosis. In: Digestive Diseases. 2010 ; Vol. 28, No. 1. pp. 105-115.
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