The etiology mystery in primary biliary cirrhosis

Carlo Selmi, M. Eric Gershwin

Research output: Contribution to journalArticlepeer-review


The etiology of primary biliary cirrhosis remains largely unknown despite numerous lines of evidence that have been recently proposed or supported. Primary biliary cirrhosis is a chronic cholestatic liver disease for which an autoimmune pathogenesis is widely accepted, mostly based on the presence of autoantibodies and autoreactive T cells. Cumulatively, association and twin studies suggest that both a susceptible genetic background and environmental factors determine disease onset. Multiple infectious and chemical candidates may contribute to the disease onset in a genetically susceptible host. Several murine models have been recently reported and include genetically determined ones as well as models induced by immunization with chemicals and bacteria.

Original languageEnglish
Pages (from-to)105-115
Number of pages11
JournalDigestive Diseases
Issue number1
Publication statusPublished - May 2010


  • Antimitochondrial autoantibodies
  • Female predominance
  • Primary biliary cirrhosis

ASJC Scopus subject areas

  • Gastroenterology


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