The EuBIVAS: Within- and between-subject biological variation data for electrolytes, lipids, urea, uric acid, total protein, total bilirubin, direct bilirubin, and glucose

AK Aarsand, J Díaz-Garzón, P Fernandez-Calle, E Guerra, M Locatelli, WA Bartlett, S Sandberg, T Røraas, F Ceriotti, UØ Sølvik, MS Sylte, A Coşkun, M Serteser, I Unsal, F Tosato, M Plebani, N Jonker, G Barla, A Carobene, on behalf of the European Federation of Clinical ChemistryLaboratory Medicine Working Group on Biological Variation

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Abstract

BACKGROUND: The European Federation of Clinical Chemistry and Laboratory Medicine European Biological Variation Study (EuBIVAS) has been established to deliver rigorously determined data describing biological variation (BV) of clinically important measurands. Here, EuBIVAS-based BV estimates of serum electrolytes, lipids, urea, uric acid, total protein, total bilirubin, direct bilirubin, and glucose, as well as their associated analytical performance specifications (APSs), are presented. METHOD: Samples were drawn from 91 healthy individuals (38 male, 53 female; age range, 21-69 years) for 10 consecutive weeks at 6 European laboratories. Samples were stored at -80 °C before duplicate analysis of all samples on an ADVIA 2400 (Siemens Healthineers). Outlier and homogeneity analyses were performed, followed by CV-ANOVA on trend-corrected data, when relevant, to determine BV estimates with CIs. RESULTS: The within-subject BV (CVI) estimates of all measurands, except for urea and LDL cholesterol, were lower than estimates available in an online BV database, with differences being most pronounced for HDL cholesterol, glucose, and direct bilirubin. Significant differences in CVIfor men and women/women
Original languageEnglish
Pages (from-to)1380-1393
Number of pages14
JournalClinical Chemistry
Volume64
Issue number9
DOIs
Publication statusPublished - 2018

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    Aarsand, AK., Díaz-Garzón, J., Fernandez-Calle, P., Guerra, E., Locatelli, M., Bartlett, WA., Sandberg, S., Røraas, T., Ceriotti, F., Sølvik, UØ., Sylte, MS., Coşkun, A., Serteser, M., Unsal, I., Tosato, F., Plebani, M., Jonker, N., Barla, G., Carobene, A., ... Variation, L. M. W. G. O. B. (2018). The EuBIVAS: Within- and between-subject biological variation data for electrolytes, lipids, urea, uric acid, total protein, total bilirubin, direct bilirubin, and glucose. Clinical Chemistry, 64(9), 1380-1393. https://doi.org/10.1373/clinchem.2018.288415