The european hematology association roadmap for european hematology research: A consensus document

Andreas Engert; Carlo Balduini; A. Brand; Bertrand Coiffier; Catherine Cordonnier; Hartmut Döhner; Thom Duyvené De Wit; Sabine Eichinger; W. E. Fibbe; Tony Green; Fleur De Haas; Achille Iolascon; Thierry Jaffredo; F. Rodeghiero; Gilles Sall Es; Jan Jacob Schuringa; Marc P E André; Isabelle André-Schmutz; A. Bacigalupo; Pierre Yves Bochud; Monique L. Den Boer; Chiara Bonini; Clara Camaschella; Andrew J. Cant; Maria Domenica Cappellini; Mario Cazzola; C. L. Celso; M. Dimopoulos; L. Douay; Elaine Dzierzak; Hermann Einsele; Andres Ferreri; Lucia De Franceschi; P. Gaulard; Berthold Gottgens; Andreas Greinacher; Paolo Gresele; John G. Gribben; Gerald De Haan; John Bjarne Hansen; A. Hochhaus; Rezan A. Kadir; Srinivas Kaveri; Valerie Kouskoff; Thomas Kühne; Paul Alexander Kyrle; Per Ljungman; G. Maschmeyer; Simón Méndez-Ferrer; Michael Milsom; Christine Mummery; Gert J. Ossenkoppele; Alessandro Pecci; Flora Peyvandi; S. Philipsen; Pieter H. Reitsma; J. M. Ribera; Antonio Risitano; Stefano Rivella; Wolfram Ruf; Timm Schroeder; M. A. Scully; Gerard Sociè; Frank Staal; Simon Stanworth; Reinhard Stauder; Stephan Stilgenbauer; H. Tamary; Kim Theilgaard-Mönch; Swee Lay Thein; Hervé Tilly; M. Trneny; William Vainchenker; Alessandro M. Vannucchi; Claudio Viscoli; H. Vrielink; Hans Zaaijer; Alberto Zanella; Lello Zolla; J. J. Zwaginga; Patricia Aguilar Martinez; Emile Van Den Akker; Shubha Allard; Nicholas P. Anagnou; Immacolata Andolfo; Jean Christophe Andrau; E. Angelucci; David Anstee; I. Aurer; Hervé Avet-Loiseau; Yesim Aydinok; Tamam Bakchoul; A. Balduini; Wilma Barcellini; Dominique Baruch; André Baruchel; Jagadeesh Bayry; Celeste Bento; Anke van den Berg; Rosa Bernardi; Paola Bianchi; Anna Bigas; A. Biondi; Milos Bohonek; Dominique Bonnet; Peter Borchmann; Niels Borregaard; S. K. Braekkan; Marcel R M van den Brink; Ellen Brodin; Lars Bullinger; Christian Buske; Barbara Butzeck; Jörg Cammenga; Elias Campo; Antonino Carbone; F. Cervantes; S. Cesaro; Pierre Charbord; F. H J Claas; Hannah Cohen; Jacqueline Conard; Paul Coppo; Joan Lluis Vives Corron; Lydie Da Costa; Frederic Davi; Ruud Delwel; I. Dianzani; Dragoslav Domanović; Peter Donnelly; Tadeja Dovč Drnovšek; Martin H. Dreyling; Ming Qing Du; Carlo Dufour; Charles Durand; Dimitar G. Efremov; Androulla Eleftheriou; Jacques Elion; Marieke Emonts; Monika Engelhardt; Sophie Ezine; Fred Falkenburg; Remi Favier; Massimo Federico; Pierre Fenaux; Jude Fitzgibbon; Johan Flygare; Robin Foà; Lesley Forrester; Frederic Galacteros; Isabella Garagiola; Chris Gardiner; Olivier Garraud; Christel Van Geet; Hartmut Geiger; J. Geissler; Ulrich Germing; Cedric Ghevaert; Domenico Girelli; Bertrand Godeau; Nicola Gökbuget; Hartmut Goldschmidt; A. Goodeve; Thomas Graf; Giovanna Graziadei; Martin Griesshammer; Yves Gruel; F. Guilhot; Stephan Von Gunten; I. C. Gyssens; Joerg P. Halter; Claire N. Harrison; Cornelis L. Harteveld; Eva Hellström-Lindberg; Olivier Hermine; Douglas Higgs; Peter Hillmen; H. H. Hirsch; P. Hoskin; Gerwin Huls; A. Inati; Peter Johnson; Antonis Kattamis; V. Kiefel; Marina Kleanthous; Hannes Klump; Daniela Krause; Johanna Kremer Hovinga; Georges Lacaud; S. Lacroix-Desmazes; Judith Landman-Parker; Steven LeGouill; Georg Lenz; M. Von Lilienfeld-Toal; M. von Lindern; Armando López-Guillermo; Enrico Lopriore; M. Lozano; Elizabeth Macintyre; Michael Makris; C. Mannhalter; Joost H A Martens; Stephan Mathas; Axel Matzdorff; Alexander Medvinsky; Pablo Menendez; A. R. Migliaccio; Kenichi Miharada; Malgorzata Mikulska; Véronique Minard; Carlos Montalbán; Mariane De Montalembert; Emili Montserrat; P. E. Morange; Joanne Mountford; Martina Muckenthaler; Carsten Müller-Tidow; Andrew Mumford; Bertrand Nadel; José Tomás Navarro; Wassim El Nemer; France Noizat-Pirenne; Brian O’Mahony; J. Oldenburg; Martin Olsson; Robert Oostendorp; A. Palumbo; Francesco Passamonti; Roger Patient; Regis Peffault de Latour; Francoise Pflumio; L. Pierelli; Antonio Piga; D. Pollard; Marc Raaijmakers; J. Radford; Ralf Rambach; A. Koneti Rao; Hana Raslova; Paolo Rebulla; David C. Rees; Vincent Ribrag; Anita Rijneveld; Sara Rinalducci; Tadeusz Robak; I. Roberts; Charlene Rodrigues; F. R. Rosendaal; Andreas Rosenwald; S. Rule; Roberta Russo; G. Saglio; Mayka Sanchez; R. E. Scharf; Peter Schlenke; John Semple; Jorge Sierra; Cynthia So-Osman; José Manuel Soria; Kostas Stamatopoulos; Bernd Stegmayr; Hendrik G. Stunnenberg; Dorine W. Swinkels; João Pedro Taborda Barata; Tom Taghon; Ali T. Taher; Evangelos Terpos; Jecko Thachil; Jean Daniel Tissot; Ivo P. Touw; Ash Toye; Ralf Trappe; A. Traverse-Glehen; Sule Unal; Sophie Vaulont; Vip Viprakasit; U. Vitolo; R. Van Wijk; Agnieszka Wójtowicz; Sacha Zeerleder; Barbara Zieger

doi:10.3324/haematol.2015.136739

The european hematology association roadmap for european hematology research: A consensus document

Andreas Engert, Carlo Balduini, A. Brand, Bertrand Coiffier, Catherine Cordonnier, Hartmut Döhner, Thom Duyvené De Wit, Sabine Eichinger, W. E. Fibbe, Tony Green, Fleur De Haas, Achille Iolascon, Thierry Jaffredo, F. Rodeghiero, Gilles Sall Es, Jan Jacob Schuringa, Marc P E André, Isabelle André-Schmutz, A. Bacigalupo, Pierre Yves BochudMonique L. Den Boer, Chiara Bonini, Clara Camaschella, Andrew J. Cant, Maria Domenica Cappellini, Mario Cazzola, C. L. Celso, M. Dimopoulos, L. Douay, Elaine Dzierzak, Hermann Einsele, Andres Ferreri, Lucia De Franceschi, P. Gaulard, Berthold Gottgens, Andreas Greinacher, Paolo Gresele, John G. Gribben, Gerald De Haan, John Bjarne Hansen, A. Hochhaus, Rezan A. Kadir, Srinivas Kaveri, Valerie Kouskoff, Thomas Kühne, Paul Alexander Kyrle, Per Ljungman, G. Maschmeyer, Simón Méndez-Ferrer, Michael Milsom, Christine Mummery, Gert J. Ossenkoppele, Alessandro Pecci, Flora Peyvandi, S. Philipsen, Pieter H. Reitsma, J. M. Ribera, Antonio Risitano, Stefano Rivella, Wolfram Ruf, Timm Schroeder, M. A. Scully, Gerard Sociè, Frank Staal, Simon Stanworth, Reinhard Stauder, Stephan Stilgenbauer, H. Tamary, Kim Theilgaard-Mönch, Swee Lay Thein, Hervé Tilly, M. Trneny, William Vainchenker, Alessandro M. Vannucchi, Claudio Viscoli, H. Vrielink, Hans Zaaijer, Alberto Zanella, Lello Zolla, J. J. Zwaginga, Patricia Aguilar Martinez, Emile Van Den Akker, Shubha Allard, Nicholas P. Anagnou, Immacolata Andolfo, Jean Christophe Andrau, E. Angelucci, David Anstee, I. Aurer, Hervé Avet-Loiseau, Yesim Aydinok, Tamam Bakchoul, A. Balduini, Wilma Barcellini, Dominique Baruch, André Baruchel, Jagadeesh Bayry, Celeste Bento, Anke van den Berg, Rosa Bernardi, Paola Bianchi, Anna Bigas, A. Biondi, Milos Bohonek, Dominique Bonnet, Peter Borchmann, Niels Borregaard, S. K. Braekkan, Marcel R M van den Brink, Ellen Brodin, Lars Bullinger, Christian Buske, Barbara Butzeck, Jörg Cammenga, Elias Campo, Antonino Carbone, F. Cervantes, S. Cesaro, Pierre Charbord, F. H J Claas, Hannah Cohen, Jacqueline Conard, Paul Coppo, Joan Lluis Vives Corron, Lydie Da Costa, Frederic Davi, Ruud Delwel, I. Dianzani, Dragoslav Domanović, Peter Donnelly, Tadeja Dovč Drnovšek, Martin H. Dreyling, Ming Qing Du, Carlo Dufour, Charles Durand, Dimitar G. Efremov, Androulla Eleftheriou, Jacques Elion, Marieke Emonts, Monika Engelhardt, Sophie Ezine, Fred Falkenburg, Remi Favier, Massimo Federico, Pierre Fenaux, Jude Fitzgibbon, Johan Flygare, Robin Foà, Lesley Forrester, Frederic Galacteros, Isabella Garagiola, Chris Gardiner, Olivier Garraud, Christel Van Geet, Hartmut Geiger, J. Geissler, Ulrich Germing, Cedric Ghevaert, Domenico Girelli, Bertrand Godeau, Nicola Gökbuget, Hartmut Goldschmidt, A. Goodeve, Thomas Graf, Giovanna Graziadei, Martin Griesshammer, Yves Gruel, F. Guilhot, Stephan Von Gunten, I. C. Gyssens, Joerg P. Halter, Claire N. Harrison, Cornelis L. Harteveld, Eva Hellström-Lindberg, Olivier Hermine, Douglas Higgs, Peter Hillmen, H. H. Hirsch, P. Hoskin, Gerwin Huls, A. Inati, Peter Johnson, Antonis Kattamis, V. Kiefel, Marina Kleanthous, Hannes Klump, Daniela Krause, Johanna Kremer Hovinga, Georges Lacaud, S. Lacroix-Desmazes, Judith Landman-Parker, Steven LeGouill, Georg Lenz, M. Von Lilienfeld-Toal, M. von Lindern, Armando López-Guillermo, Enrico Lopriore, M. Lozano, Elizabeth Macintyre, Michael Makris, C. Mannhalter, Joost H A Martens, Stephan Mathas, Axel Matzdorff, Alexander Medvinsky, Pablo Menendez, A. R. Migliaccio, Kenichi Miharada, Malgorzata Mikulska, Véronique Minard, Carlos Montalbán, Mariane De Montalembert, Emili Montserrat, P. E. Morange, Joanne Mountford, Martina Muckenthaler, Carsten Müller-Tidow, Andrew Mumford, Bertrand Nadel, José Tomás Navarro, Wassim El Nemer, France Noizat-Pirenne, Brian O’Mahony, J. Oldenburg, Martin Olsson, Robert Oostendorp, A. Palumbo, Francesco Passamonti, Roger Patient, Regis Peffault de Latour, Francoise Pflumio, L. Pierelli, Antonio Piga, D. Pollard, Marc Raaijmakers, J. Radford, Ralf Rambach, A. Koneti Rao, Hana Raslova, Paolo Rebulla, David C. Rees, Vincent Ribrag, Anita Rijneveld, Sara Rinalducci, Tadeusz Robak, I. Roberts, Charlene Rodrigues, F. R. Rosendaal, Andreas Rosenwald, S. Rule, Roberta Russo, G. Saglio, Mayka Sanchez, R. E. Scharf, Peter Schlenke, John Semple, Jorge Sierra, Cynthia So-Osman, José Manuel Soria, Kostas Stamatopoulos, Bernd Stegmayr, Hendrik G. Stunnenberg, Dorine W. Swinkels, João Pedro Taborda Barata, Tom Taghon, Ali T. Taher, Evangelos Terpos, Jecko Thachil, Jean Daniel Tissot, Ivo P. Touw, Ash Toye, Ralf Trappe, A. Traverse-Glehen, Sule Unal, Sophie Vaulont, Vip Viprakasit, U. Vitolo, R. Van Wijk, Agnieszka Wójtowicz, Sacha Zeerleder, Barbara Zieger

Research output: Contribution to journal › Article › peer-review

Abstract

The European Hematology Association (EHA) Roadmap for European Hematology Research highlights major achievements in diagnosis and treatment of blood disorders and identifies the greatest unmet clinical and scientific needs in those areas to enable better funded, more focused European hematology research. Initiated by the EHA, around 300 experts contributed to the consensus document, which will help European policy makers, research funders, research organizations, researchers, and patient groups make better informed decisions on hematology research. It also aims to raise public awareness of the burden of blood disorders on European society, which purely in economic terms is estimated at ∈ European Hematology Association (EHA) Roadmap for European Hematology Research highlights major achievements in diagnosis and treatment of blood disorders and identifies the greatest unmet clinical and scientific needs in those areas to enable better fu treatments, sometimes in revolutionary ways. This progress highlights the potential of focused basic research programs such as this EHA Roadmap. The EHA Roadmap identifies nine ‘sections’ in hematology: normal hematopoiesis, malignant lymphoid and myeloid diseases, anemias and related diseases, platelet disorders, blood coagulation and hemostatic disorders, transfusion medicine, infections in hematology, and hematopoietic stem cell transplantation. These sections span 60 smaller groups of diseases or disorders. The EHA Roadmap identifies priorities and needs across the field of hematology, including those to develop targeted therapies based on genomic profiling and chemical biology, to eradicate minimal residual malignant disease, and to develop cellular immunotherapies, combination treatments, gene therapies, hematopoietic stem cell treatments, and treatments that are better tolerated by elderly patients.

Original language	English
Pages (from-to)	115-208
Number of pages	94
Journal	Haematologica
Volume	101
Issue number	2
DOIs	https://doi.org/10.3324/haematol.2015.136739
Publication status	Published - Feb 1 2016

ASJC Scopus subject areas

Hematology

Access to Document

10.3324/haematol.2015.136739

Cite this

Engert, A., Balduini, C., Brand, A., Coiffier, B., Cordonnier, C., Döhner, H., De Wit, T. D., Eichinger, S., Fibbe, W. E., Green, T., De Haas, F., Iolascon, A., Jaffredo, T., Rodeghiero, F., Sall Es, G., Schuringa, J. J., André, M. P. E., André-Schmutz, I., Bacigalupo, A., ... Zieger, B. (2016). The european hematology association roadmap for european hematology research: A consensus document. Haematologica, 101(2), 115-208. https://doi.org/10.3324/haematol.2015.136739

Engert, A, Balduini, C, Brand, A, Coiffier, B, Cordonnier, C, Döhner, H, De Wit, TD, Eichinger, S, Fibbe, WE, Green, T, De Haas, F, Iolascon, A, Jaffredo, T, Rodeghiero, F, Sall Es, G, Schuringa, JJ, André, MPE, André-Schmutz, I, Bacigalupo, A, Bochud, PY, Den Boer, ML, Bonini, C, Camaschella, C, Cant, AJ, Cappellini, MD , Cazzola, M, Celso, CL, Dimopoulos, M, Douay, L, Dzierzak, E, Einsele, H, Ferreri, A, De Franceschi, L, Gaulard, P, Gottgens, B, Greinacher, A, Gresele, P, Gribben, JG, De Haan, G, Hansen, JB, Hochhaus, A, Kadir, RA, Kaveri, S, Kouskoff, V, Kühne, T, Kyrle, PA, Ljungman, P, Maschmeyer, G, Méndez-Ferrer, S, Milsom, M, Mummery, C, Ossenkoppele, GJ, Pecci, A , Peyvandi, F, Philipsen, S, Reitsma, PH, Ribera, JM, Risitano, A, Rivella, S, Ruf, W, Schroeder, T, Scully, MA, Sociè, G, Staal, F, Stanworth, S, Stauder, R, Stilgenbauer, S, Tamary, H, Theilgaard-Mönch, K, Thein, SL, Tilly, H, Trneny, M, Vainchenker, W, Vannucchi, AM, Viscoli, C, Vrielink, H, Zaaijer, H, Zanella, A, Zolla, L, Zwaginga, JJ, Martinez, PA, Van Den Akker, E, Allard, S, Anagnou, NP, Andolfo, I, Andrau, JC, Angelucci, E, Anstee, D, Aurer, I, Avet-Loiseau, H, Aydinok, Y, Bakchoul, T, Balduini, A, Barcellini, W, Baruch, D, Baruchel, A, Bayry, J, Bento, C, van den Berg, A, Bernardi, R, Bianchi, P, Bigas, A, Biondi, A, Bohonek, M, Bonnet, D, Borchmann, P, Borregaard, N, Braekkan, SK, van den Brink, MRM, Brodin, E, Bullinger, L, Buske, C, Butzeck, B, Cammenga, J, Campo, E, Carbone, A, Cervantes, F, Cesaro, S, Charbord, P, Claas, FHJ, Cohen, H, Conard, J, Coppo, P, Vives Corron, JL, Da Costa, L, Davi, F, Delwel, R, Dianzani, I, Domanović, D, Donnelly, P, Drnovšek, TD, Dreyling, MH, Du, MQ, Dufour, C, Durand, C, Efremov, DG, Eleftheriou, A, Elion, J, Emonts, M, Engelhardt, M, Ezine, S, Falkenburg, F, Favier, R, Federico, M, Fenaux, P, Fitzgibbon, J, Flygare, J, Foà, R, Forrester, L, Galacteros, F, Garagiola, I, Gardiner, C, Garraud, O, Van Geet, C, Geiger, H, Geissler, J, Germing, U, Ghevaert, C, Girelli, D, Godeau, B, Gökbuget, N, Goldschmidt, H, Goodeve, A, Graf, T, Graziadei, G, Griesshammer, M, Gruel, Y, Guilhot, F, Von Gunten, S, Gyssens, IC, Halter, JP, Harrison, CN, Harteveld, CL, Hellström-Lindberg, E, Hermine, O, Higgs, D, Hillmen, P, Hirsch, HH, Hoskin, P, Huls, G, Inati, A, Johnson, P, Kattamis, A, Kiefel, V, Kleanthous, M, Klump, H, Krause, D, Hovinga, JK, Lacaud, G, Lacroix-Desmazes, S, Landman-Parker, J, LeGouill, S, Lenz, G, Von Lilienfeld-Toal, M, von Lindern, M, López-Guillermo, A, Lopriore, E, Lozano, M, Macintyre, E, Makris, M, Mannhalter, C, Martens, JHA, Mathas, S, Matzdorff, A, Medvinsky, A, Menendez, P, Migliaccio, AR, Miharada, K, Mikulska, M, Minard, V, Montalbán, C, De Montalembert, M, Montserrat, E, Morange, PE, Mountford, J, Muckenthaler, M, Müller-Tidow, C, Mumford, A, Nadel, B, Navarro, JT, El Nemer, W, Noizat-Pirenne, F, O’Mahony, B, Oldenburg, J, Olsson, M, Oostendorp, R, Palumbo, A, Passamonti, F, Patient, R, de Latour, RP, Pflumio, F, Pierelli, L, Piga, A, Pollard, D, Raaijmakers, M, Radford, J, Rambach, R, Koneti Rao, A, Raslova, H, Rebulla, P, Rees, DC, Ribrag, V, Rijneveld, A, Rinalducci, S, Robak, T, Roberts, I, Rodrigues, C, Rosendaal, FR, Rosenwald, A, Rule, S, Russo, R, Saglio, G, Sanchez, M, Scharf, RE, Schlenke, P, Semple, J, Sierra, J, So-Osman, C, Soria, JM, Stamatopoulos, K, Stegmayr, B, Stunnenberg, HG, Swinkels, DW, Barata, JPT, Taghon, T, Taher, AT, Terpos, E, Thachil, J, Tissot, JD, Touw, IP, Toye, A, Trappe, R, Traverse-Glehen, A, Unal, S, Vaulont, S, Viprakasit, V, Vitolo, U, Van Wijk, R, Wójtowicz, A, Zeerleder, S & Zieger, B 2016, 'The european hematology association roadmap for european hematology research: A consensus document', Haematologica, vol. 101, no. 2, pp. 115-208. https://doi.org/10.3324/haematol.2015.136739

@article{7e1eb13341a74b08982ec8237110aead,

title = "The european hematology association roadmap for european hematology research: A consensus document",

abstract = "The European Hematology Association (EHA) Roadmap for European Hematology Research highlights major achievements in diagnosis and treatment of blood disorders and identifies the greatest unmet clinical and scientific needs in those areas to enable better funded, more focused European hematology research. Initiated by the EHA, around 300 experts contributed to the consensus document, which will help European policy makers, research funders, research organizations, researchers, and patient groups make better informed decisions on hematology research. It also aims to raise public awareness of the burden of blood disorders on European society, which purely in economic terms is estimated at ∈ European Hematology Association (EHA) Roadmap for European Hematology Research highlights major achievements in diagnosis and treatment of blood disorders and identifies the greatest unmet clinical and scientific needs in those areas to enable better fu treatments, sometimes in revolutionary ways. This progress highlights the potential of focused basic research programs such as this EHA Roadmap. The EHA Roadmap identifies nine {\textquoteleft}sections{\textquoteright} in hematology: normal hematopoiesis, malignant lymphoid and myeloid diseases, anemias and related diseases, platelet disorders, blood coagulation and hemostatic disorders, transfusion medicine, infections in hematology, and hematopoietic stem cell transplantation. These sections span 60 smaller groups of diseases or disorders. The EHA Roadmap identifies priorities and needs across the field of hematology, including those to develop targeted therapies based on genomic profiling and chemical biology, to eradicate minimal residual malignant disease, and to develop cellular immunotherapies, combination treatments, gene therapies, hematopoietic stem cell treatments, and treatments that are better tolerated by elderly patients.",

author = "Andreas Engert and Carlo Balduini and A. Brand and Bertrand Coiffier and Catherine Cordonnier and Hartmut D{\"o}hner and {De Wit}, {Thom Duyven{\'e}} and Sabine Eichinger and Fibbe, {W. E.} and Tony Green and {De Haas}, Fleur and Achille Iolascon and Thierry Jaffredo and F. Rodeghiero and {Sall Es}, Gilles and Schuringa, {Jan Jacob} and Andr{\'e}, {Marc P E} and Isabelle Andr{\'e}-Schmutz and A. Bacigalupo and Bochud, {Pierre Yves} and {Den Boer}, {Monique L.} and Chiara Bonini and Clara Camaschella and Cant, {Andrew J.} and Cappellini, {Maria Domenica} and Mario Cazzola and Celso, {C. L.} and M. Dimopoulos and L. Douay and Elaine Dzierzak and Hermann Einsele and Andres Ferreri and {De Franceschi}, Lucia and P. Gaulard and Berthold Gottgens and Andreas Greinacher and Paolo Gresele and Gribben, {John G.} and {De Haan}, Gerald and Hansen, {John Bjarne} and A. Hochhaus and Kadir, {Rezan A.} and Srinivas Kaveri and Valerie Kouskoff and Thomas K{\"u}hne and Kyrle, {Paul Alexander} and Per Ljungman and G. Maschmeyer and Sim{\'o}n M{\'e}ndez-Ferrer and Michael Milsom and Christine Mummery and Ossenkoppele, {Gert J.} and Alessandro Pecci and Flora Peyvandi and S. Philipsen and Reitsma, {Pieter H.} and Ribera, {J. M.} and Antonio Risitano and Stefano Rivella and Wolfram Ruf and Timm Schroeder and Scully, {M. A.} and Gerard Soci{\`e} and Frank Staal and Simon Stanworth and Reinhard Stauder and Stephan Stilgenbauer and H. Tamary and Kim Theilgaard-M{\"o}nch and Thein, {Swee Lay} and Herv{\'e} Tilly and M. Trneny and William Vainchenker and Vannucchi, {Alessandro M.} and Claudio Viscoli and H. Vrielink and Hans Zaaijer and Alberto Zanella and Lello Zolla and Zwaginga, {J. J.} and Martinez, {Patricia Aguilar} and {Van Den Akker}, Emile and Shubha Allard and Anagnou, {Nicholas P.} and Immacolata Andolfo and Andrau, {Jean Christophe} and E. Angelucci and David Anstee and I. Aurer and Herv{\'e} Avet-Loiseau and Yesim Aydinok and Tamam Bakchoul and A. Balduini and Wilma Barcellini and Dominique Baruch and Andr{\'e} Baruchel and Jagadeesh Bayry and Celeste Bento and {van den Berg}, Anke and Rosa Bernardi and Paola Bianchi and Anna Bigas and A. Biondi and Milos Bohonek and Dominique Bonnet and Peter Borchmann and Niels Borregaard and Braekkan, {S. K.} and {van den Brink}, {Marcel R M} and Ellen Brodin and Lars Bullinger and Christian Buske and Barbara Butzeck and J{\"o}rg Cammenga and Elias Campo and Antonino Carbone and F. Cervantes and S. Cesaro and Pierre Charbord and Claas, {F. H J} and Hannah Cohen and Jacqueline Conard and Paul Coppo and {Vives Corron}, {Joan Lluis} and {Da Costa}, Lydie and Frederic Davi and Ruud Delwel and I. Dianzani and Dragoslav Domanovi{\'c} and Peter Donnelly and Drnov{\v s}ek, {Tadeja Dov{\v c}} and Dreyling, {Martin H.} and Du, {Ming Qing} and Carlo Dufour and Charles Durand and Efremov, {Dimitar G.} and Androulla Eleftheriou and Jacques Elion and Marieke Emonts and Monika Engelhardt and Sophie Ezine and Fred Falkenburg and Remi Favier and Massimo Federico and Pierre Fenaux and Jude Fitzgibbon and Johan Flygare and Robin Fo{\`a} and Lesley Forrester and Frederic Galacteros and Isabella Garagiola and Chris Gardiner and Olivier Garraud and {Van Geet}, Christel and Hartmut Geiger and J. Geissler and Ulrich Germing and Cedric Ghevaert and Domenico Girelli and Bertrand Godeau and Nicola G{\"o}kbuget and Hartmut Goldschmidt and A. Goodeve and Thomas Graf and Giovanna Graziadei and Martin Griesshammer and Yves Gruel and F. Guilhot and {Von Gunten}, Stephan and Gyssens, {I. C.} and Halter, {Joerg P.} and Harrison, {Claire N.} and Harteveld, {Cornelis L.} and Eva Hellstr{\"o}m-Lindberg and Olivier Hermine and Douglas Higgs and Peter Hillmen and Hirsch, {H. H.} and P. Hoskin and Gerwin Huls and A. Inati and Peter Johnson and Antonis Kattamis and V. Kiefel and Marina Kleanthous and Hannes Klump and Daniela Krause and Hovinga, {Johanna Kremer} and Georges Lacaud and S. Lacroix-Desmazes and Judith Landman-Parker and Steven LeGouill and Georg Lenz and {Von Lilienfeld-Toal}, M. and {von Lindern}, M. and Armando L{\'o}pez-Guillermo and Enrico Lopriore and M. Lozano and Elizabeth Macintyre and Michael Makris and C. Mannhalter and Martens, {Joost H A} and Stephan Mathas and Axel Matzdorff and Alexander Medvinsky and Pablo Menendez and Migliaccio, {A. R.} and Kenichi Miharada and Malgorzata Mikulska and V{\'e}ronique Minard and Carlos Montalb{\'a}n and {De Montalembert}, Mariane and Emili Montserrat and Morange, {P. E.} and Joanne Mountford and Martina Muckenthaler and Carsten M{\"u}ller-Tidow and Andrew Mumford and Bertrand Nadel and Navarro, {Jos{\'e} Tom{\'a}s} and {El Nemer}, Wassim and France Noizat-Pirenne and Brian O{\textquoteright}Mahony and J. Oldenburg and Martin Olsson and Robert Oostendorp and A. Palumbo and Francesco Passamonti and Roger Patient and {de Latour}, {Regis Peffault} and Francoise Pflumio and L. Pierelli and Antonio Piga and D. Pollard and Marc Raaijmakers and J. Radford and Ralf Rambach and {Koneti Rao}, A. and Hana Raslova and Paolo Rebulla and Rees, {David C.} and Vincent Ribrag and Anita Rijneveld and Sara Rinalducci and Tadeusz Robak and I. Roberts and Charlene Rodrigues and Rosendaal, {F. R.} and Andreas Rosenwald and S. Rule and Roberta Russo and G. Saglio and Mayka Sanchez and Scharf, {R. E.} and Peter Schlenke and John Semple and Jorge Sierra and Cynthia So-Osman and Soria, {Jos{\'e} Manuel} and Kostas Stamatopoulos and Bernd Stegmayr and Stunnenberg, {Hendrik G.} and Swinkels, {Dorine W.} and Barata, {Jo{\~a}o Pedro Taborda} and Tom Taghon and Taher, {Ali T.} and Evangelos Terpos and Jecko Thachil and Tissot, {Jean Daniel} and Touw, {Ivo P.} and Ash Toye and Ralf Trappe and A. Traverse-Glehen and Sule Unal and Sophie Vaulont and Vip Viprakasit and U. Vitolo and {Van Wijk}, R. and Agnieszka W{\'o}jtowicz and Sacha Zeerleder and Barbara Zieger",

year = "2016",

month = feb,

day = "1",

doi = "10.3324/haematol.2015.136739",

language = "English",

volume = "101",

pages = "115--208",

journal = "Haematologica",

issn = "0390-6078",

publisher = "NLM (Medline)",

number = "2",

}

TY - JOUR

T1 - The european hematology association roadmap for european hematology research

T2 - A consensus document

AU - Engert, Andreas

AU - Balduini, Carlo

AU - Brand, A.

AU - Coiffier, Bertrand

AU - Cordonnier, Catherine

AU - Döhner, Hartmut

AU - De Wit, Thom Duyvené

AU - Eichinger, Sabine

AU - Fibbe, W. E.

AU - Green, Tony

AU - De Haas, Fleur

AU - Iolascon, Achille

AU - Jaffredo, Thierry

AU - Rodeghiero, F.

AU - Sall Es, Gilles

AU - Schuringa, Jan Jacob

AU - André, Marc P E

AU - André-Schmutz, Isabelle

AU - Bacigalupo, A.

AU - Bochud, Pierre Yves

AU - Den Boer, Monique L.

AU - Bonini, Chiara

AU - Camaschella, Clara

AU - Cant, Andrew J.

AU - Cappellini, Maria Domenica

AU - Cazzola, Mario

AU - Celso, C. L.

AU - Dimopoulos, M.

AU - Douay, L.

AU - Dzierzak, Elaine

AU - Einsele, Hermann

AU - Ferreri, Andres

AU - De Franceschi, Lucia

AU - Gaulard, P.

AU - Gottgens, Berthold

AU - Greinacher, Andreas

AU - Gresele, Paolo

AU - Gribben, John G.

AU - De Haan, Gerald

AU - Hansen, John Bjarne

AU - Hochhaus, A.

AU - Kadir, Rezan A.

AU - Kaveri, Srinivas

AU - Kouskoff, Valerie

AU - Kühne, Thomas

AU - Kyrle, Paul Alexander

AU - Ljungman, Per

AU - Maschmeyer, G.

AU - Méndez-Ferrer, Simón

AU - Milsom, Michael

AU - Mummery, Christine

AU - Ossenkoppele, Gert J.

AU - Pecci, Alessandro

AU - Peyvandi, Flora

AU - Philipsen, S.

AU - Reitsma, Pieter H.

AU - Ribera, J. M.

AU - Risitano, Antonio

AU - Rivella, Stefano

AU - Ruf, Wolfram

AU - Schroeder, Timm

AU - Scully, M. A.

AU - Sociè, Gerard

AU - Staal, Frank

AU - Stanworth, Simon

AU - Stauder, Reinhard

AU - Stilgenbauer, Stephan

AU - Tamary, H.

AU - Theilgaard-Mönch, Kim

AU - Thein, Swee Lay

AU - Tilly, Hervé

AU - Trneny, M.

AU - Vainchenker, William

AU - Vannucchi, Alessandro M.

AU - Viscoli, Claudio

AU - Vrielink, H.

AU - Zaaijer, Hans

AU - Zanella, Alberto

AU - Zolla, Lello

AU - Zwaginga, J. J.

AU - Martinez, Patricia Aguilar

AU - Van Den Akker, Emile

AU - Allard, Shubha

AU - Anagnou, Nicholas P.

AU - Andolfo, Immacolata

AU - Andrau, Jean Christophe

AU - Angelucci, E.

AU - Anstee, David

AU - Aurer, I.

AU - Avet-Loiseau, Hervé

AU - Aydinok, Yesim

AU - Bakchoul, Tamam

AU - Balduini, A.

AU - Barcellini, Wilma

AU - Baruch, Dominique

AU - Baruchel, André

AU - Bayry, Jagadeesh

AU - Bento, Celeste

AU - van den Berg, Anke

AU - Bernardi, Rosa

AU - Bianchi, Paola

AU - Bigas, Anna

AU - Biondi, A.

AU - Bohonek, Milos

AU - Bonnet, Dominique

AU - Borchmann, Peter

AU - Borregaard, Niels

AU - Braekkan, S. K.

AU - van den Brink, Marcel R M

AU - Brodin, Ellen

AU - Bullinger, Lars

AU - Buske, Christian

AU - Butzeck, Barbara

AU - Cammenga, Jörg

AU - Campo, Elias

AU - Carbone, Antonino

AU - Cervantes, F.

AU - Cesaro, S.

AU - Charbord, Pierre

AU - Claas, F. H J

AU - Cohen, Hannah

AU - Conard, Jacqueline

AU - Coppo, Paul

AU - Vives Corron, Joan Lluis

AU - Da Costa, Lydie

AU - Davi, Frederic

AU - Delwel, Ruud

AU - Dianzani, I.

AU - Domanović, Dragoslav

AU - Donnelly, Peter

AU - Drnovšek, Tadeja Dovč

AU - Dreyling, Martin H.

AU - Du, Ming Qing

AU - Dufour, Carlo

AU - Durand, Charles

AU - Efremov, Dimitar G.

AU - Eleftheriou, Androulla

AU - Elion, Jacques

AU - Emonts, Marieke

AU - Engelhardt, Monika

AU - Ezine, Sophie

AU - Falkenburg, Fred

AU - Favier, Remi

AU - Federico, Massimo

AU - Fenaux, Pierre

AU - Fitzgibbon, Jude

AU - Flygare, Johan

AU - Foà, Robin

AU - Forrester, Lesley

AU - Galacteros, Frederic

AU - Garagiola, Isabella

AU - Gardiner, Chris

AU - Garraud, Olivier

AU - Van Geet, Christel

AU - Geiger, Hartmut

AU - Geissler, J.

AU - Germing, Ulrich

AU - Ghevaert, Cedric

AU - Girelli, Domenico

AU - Godeau, Bertrand

AU - Gökbuget, Nicola

AU - Goldschmidt, Hartmut

AU - Goodeve, A.

AU - Graf, Thomas

AU - Graziadei, Giovanna

AU - Griesshammer, Martin

AU - Gruel, Yves

AU - Guilhot, F.

AU - Von Gunten, Stephan

AU - Gyssens, I. C.

AU - Halter, Joerg P.

AU - Harrison, Claire N.

AU - Harteveld, Cornelis L.

AU - Hellström-Lindberg, Eva

AU - Hermine, Olivier

AU - Higgs, Douglas

AU - Hillmen, Peter

AU - Hirsch, H. H.

AU - Hoskin, P.

AU - Huls, Gerwin

AU - Inati, A.

AU - Johnson, Peter

AU - Kattamis, Antonis

AU - Kiefel, V.

AU - Kleanthous, Marina

AU - Klump, Hannes

AU - Krause, Daniela

AU - Hovinga, Johanna Kremer

AU - Lacaud, Georges

AU - Lacroix-Desmazes, S.

AU - Landman-Parker, Judith

AU - LeGouill, Steven

AU - Lenz, Georg

AU - Von Lilienfeld-Toal, M.

AU - von Lindern, M.

AU - López-Guillermo, Armando

AU - Lopriore, Enrico

AU - Lozano, M.

AU - Macintyre, Elizabeth

AU - Makris, Michael

AU - Mannhalter, C.

AU - Martens, Joost H A

AU - Mathas, Stephan

AU - Matzdorff, Axel

AU - Medvinsky, Alexander

AU - Menendez, Pablo

AU - Migliaccio, A. R.

AU - Miharada, Kenichi

AU - Mikulska, Malgorzata

AU - Minard, Véronique

AU - Montalbán, Carlos

AU - De Montalembert, Mariane

AU - Montserrat, Emili

AU - Morange, P. E.

AU - Mountford, Joanne

AU - Muckenthaler, Martina

AU - Müller-Tidow, Carsten

AU - Mumford, Andrew

AU - Nadel, Bertrand

AU - Navarro, José Tomás

AU - El Nemer, Wassim

AU - Noizat-Pirenne, France

AU - O’Mahony, Brian

AU - Oldenburg, J.

AU - Olsson, Martin

AU - Oostendorp, Robert

AU - Palumbo, A.

AU - Passamonti, Francesco

AU - Patient, Roger

AU - de Latour, Regis Peffault

AU - Pflumio, Francoise

AU - Pierelli, L.

AU - Piga, Antonio

AU - Pollard, D.

AU - Raaijmakers, Marc

AU - Radford, J.

AU - Rambach, Ralf

AU - Koneti Rao, A.

AU - Raslova, Hana

AU - Rebulla, Paolo

AU - Rees, David C.

AU - Ribrag, Vincent

AU - Rijneveld, Anita

AU - Rinalducci, Sara

AU - Robak, Tadeusz

AU - Roberts, I.

AU - Rodrigues, Charlene

AU - Rosendaal, F. R.

AU - Rosenwald, Andreas

AU - Rule, S.

AU - Russo, Roberta

AU - Saglio, G.

AU - Sanchez, Mayka

AU - Scharf, R. E.

AU - Schlenke, Peter

AU - Semple, John

AU - Sierra, Jorge

AU - So-Osman, Cynthia

AU - Soria, José Manuel

AU - Stamatopoulos, Kostas

AU - Stegmayr, Bernd

AU - Stunnenberg, Hendrik G.

AU - Swinkels, Dorine W.

AU - Barata, João Pedro Taborda

AU - Taghon, Tom

AU - Taher, Ali T.

AU - Terpos, Evangelos

AU - Thachil, Jecko

AU - Tissot, Jean Daniel

AU - Touw, Ivo P.

AU - Toye, Ash

AU - Trappe, Ralf

AU - Traverse-Glehen, A.

AU - Unal, Sule

AU - Vaulont, Sophie

AU - Viprakasit, Vip

AU - Vitolo, U.

AU - Van Wijk, R.

AU - Wójtowicz, Agnieszka

AU - Zeerleder, Sacha

AU - Zieger, Barbara

PY - 2016/2/1

Y1 - 2016/2/1

N2 - The European Hematology Association (EHA) Roadmap for European Hematology Research highlights major achievements in diagnosis and treatment of blood disorders and identifies the greatest unmet clinical and scientific needs in those areas to enable better funded, more focused European hematology research. Initiated by the EHA, around 300 experts contributed to the consensus document, which will help European policy makers, research funders, research organizations, researchers, and patient groups make better informed decisions on hematology research. It also aims to raise public awareness of the burden of blood disorders on European society, which purely in economic terms is estimated at ∈ European Hematology Association (EHA) Roadmap for European Hematology Research highlights major achievements in diagnosis and treatment of blood disorders and identifies the greatest unmet clinical and scientific needs in those areas to enable better fu treatments, sometimes in revolutionary ways. This progress highlights the potential of focused basic research programs such as this EHA Roadmap. The EHA Roadmap identifies nine ‘sections’ in hematology: normal hematopoiesis, malignant lymphoid and myeloid diseases, anemias and related diseases, platelet disorders, blood coagulation and hemostatic disorders, transfusion medicine, infections in hematology, and hematopoietic stem cell transplantation. These sections span 60 smaller groups of diseases or disorders. The EHA Roadmap identifies priorities and needs across the field of hematology, including those to develop targeted therapies based on genomic profiling and chemical biology, to eradicate minimal residual malignant disease, and to develop cellular immunotherapies, combination treatments, gene therapies, hematopoietic stem cell treatments, and treatments that are better tolerated by elderly patients.

AB - The European Hematology Association (EHA) Roadmap for European Hematology Research highlights major achievements in diagnosis and treatment of blood disorders and identifies the greatest unmet clinical and scientific needs in those areas to enable better funded, more focused European hematology research. Initiated by the EHA, around 300 experts contributed to the consensus document, which will help European policy makers, research funders, research organizations, researchers, and patient groups make better informed decisions on hematology research. It also aims to raise public awareness of the burden of blood disorders on European society, which purely in economic terms is estimated at ∈ European Hematology Association (EHA) Roadmap for European Hematology Research highlights major achievements in diagnosis and treatment of blood disorders and identifies the greatest unmet clinical and scientific needs in those areas to enable better fu treatments, sometimes in revolutionary ways. This progress highlights the potential of focused basic research programs such as this EHA Roadmap. The EHA Roadmap identifies nine ‘sections’ in hematology: normal hematopoiesis, malignant lymphoid and myeloid diseases, anemias and related diseases, platelet disorders, blood coagulation and hemostatic disorders, transfusion medicine, infections in hematology, and hematopoietic stem cell transplantation. These sections span 60 smaller groups of diseases or disorders. The EHA Roadmap identifies priorities and needs across the field of hematology, including those to develop targeted therapies based on genomic profiling and chemical biology, to eradicate minimal residual malignant disease, and to develop cellular immunotherapies, combination treatments, gene therapies, hematopoietic stem cell treatments, and treatments that are better tolerated by elderly patients.

UR - http://www.scopus.com/inward/record.url?scp=84981361090&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=84981361090&partnerID=8YFLogxK

U2 - 10.3324/haematol.2015.136739

DO - 10.3324/haematol.2015.136739

M3 - Article

VL - 101

SP - 115

EP - 208

JO - Haematologica

JF - Haematologica

SN - 0390-6078

IS - 2

ER -

The european hematology association roadmap for european hematology research: A consensus document

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