The European Society for Blood and Marrow Transplantation (EBMT) Consensus Guidelines for the Detection and Treatment of Donor-specific Anti-HLA Antibodies (DSA) in Haploidentical Hematopoietic Cell Transplantation

SO Ciurea, K Cao, M Fernadez-Vina, P Kongtim, MA Malki, E Fuchs, L Luznik, XJ Huang, F Ciceri, F Locatelli, Franco Aversa, L Castagna, A Bacigalupo, M Martelli, D Blaise, R Handgretinger, DC Roy, P O'Donnell, A Bashey, HM LazarusK Ballen, BN Savani, M Mohty, A Nagler

Research output: Contribution to journalArticle

Abstract

Haploidentical donors are now increasingly considered for transplantation in the absence of HLA-matched donors or when an urgent transplant is needed. Donor-specific anti-HLA antibodies (DSA) have been recently recognized as an important barrier against successful engraftment of donor cells, which can affect transplant survival. DSA appear more prevalent in this type of transplant due to higher likelihood of alloimmunization of multiparous females against offspring's HLA antigens, and the degree of mismatch. Here we summarize the evidence for the role of DSA in the development of primary graft failure in haploidentical transplantation and provide consensus recommendations from the European Society for Blood and Marrow Transplant Group on testing, monitoring, and treatment of patients with DSA receiving haploidentical hematopoietic progenitor cell transplantation. © 2017 The Author(s).
Original languageEnglish
Pages (from-to)521-534
Number of pages14
JournalBone Marrow Transplantation
Volume53
Issue number5
DOIs
Publication statusPublished - 2018

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Cell Transplantation
Anti-Idiotypic Antibodies
Transplantation
Bone Marrow
Guidelines
Transplants
Therapeutics
Physiologic Monitoring
HLA Antigens
Hematopoietic Stem Cells

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The European Society for Blood and Marrow Transplantation (EBMT) Consensus Guidelines for the Detection and Treatment of Donor-specific Anti-HLA Antibodies (DSA) in Haploidentical Hematopoietic Cell Transplantation. / Ciurea, SO; Cao, K; Fernadez-Vina, M; Kongtim, P; Malki, MA; Fuchs, E; Luznik, L; Huang, XJ; Ciceri, F; Locatelli, F; Aversa, Franco; Castagna, L; Bacigalupo, A; Martelli, M; Blaise, D; Handgretinger, R; Roy, DC; O'Donnell, P; Bashey, A; Lazarus, HM; Ballen, K; Savani, BN; Mohty, M; Nagler, A.

In: Bone Marrow Transplantation, Vol. 53, No. 5, 2018, p. 521-534.

Research output: Contribution to journalArticle

Ciurea, SO, Cao, K, Fernadez-Vina, M, Kongtim, P, Malki, MA, Fuchs, E, Luznik, L, Huang, XJ, Ciceri, F, Locatelli, F, Aversa, F, Castagna, L, Bacigalupo, A, Martelli, M, Blaise, D, Handgretinger, R, Roy, DC, O'Donnell, P, Bashey, A, Lazarus, HM, Ballen, K, Savani, BN, Mohty, M & Nagler, A 2018, 'The European Society for Blood and Marrow Transplantation (EBMT) Consensus Guidelines for the Detection and Treatment of Donor-specific Anti-HLA Antibodies (DSA) in Haploidentical Hematopoietic Cell Transplantation', Bone Marrow Transplantation, vol. 53, no. 5, pp. 521-534. https://doi.org/10.1038/s41409-017-0062-8
Ciurea, SO ; Cao, K ; Fernadez-Vina, M ; Kongtim, P ; Malki, MA ; Fuchs, E ; Luznik, L ; Huang, XJ ; Ciceri, F ; Locatelli, F ; Aversa, Franco ; Castagna, L ; Bacigalupo, A ; Martelli, M ; Blaise, D ; Handgretinger, R ; Roy, DC ; O'Donnell, P ; Bashey, A ; Lazarus, HM ; Ballen, K ; Savani, BN ; Mohty, M ; Nagler, A. / The European Society for Blood and Marrow Transplantation (EBMT) Consensus Guidelines for the Detection and Treatment of Donor-specific Anti-HLA Antibodies (DSA) in Haploidentical Hematopoietic Cell Transplantation. In: Bone Marrow Transplantation. 2018 ; Vol. 53, No. 5. pp. 521-534.
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AU - Ciurea, SO

AU - Cao, K

AU - Fernadez-Vina, M

AU - Kongtim, P

AU - Malki, MA

AU - Fuchs, E

AU - Luznik, L

AU - Huang, XJ

AU - Ciceri, F

AU - Locatelli, F

AU - Aversa, Franco

AU - Castagna, L

AU - Bacigalupo, A

AU - Martelli, M

AU - Blaise, D

AU - Handgretinger, R

AU - Roy, DC

AU - O'Donnell, P

AU - Bashey, A

AU - Lazarus, HM

AU - Ballen, K

AU - Savani, BN

AU - Mohty, M

AU - Nagler, A

PY - 2018

Y1 - 2018

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AB - Haploidentical donors are now increasingly considered for transplantation in the absence of HLA-matched donors or when an urgent transplant is needed. Donor-specific anti-HLA antibodies (DSA) have been recently recognized as an important barrier against successful engraftment of donor cells, which can affect transplant survival. DSA appear more prevalent in this type of transplant due to higher likelihood of alloimmunization of multiparous females against offspring's HLA antigens, and the degree of mismatch. Here we summarize the evidence for the role of DSA in the development of primary graft failure in haploidentical transplantation and provide consensus recommendations from the European Society for Blood and Marrow Transplant Group on testing, monitoring, and treatment of patients with DSA receiving haploidentical hematopoietic progenitor cell transplantation. © 2017 The Author(s).

U2 - 10.1038/s41409-017-0062-8

DO - 10.1038/s41409-017-0062-8

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JO - Bone Marrow Transplantation

JF - Bone Marrow Transplantation

SN - 0268-3369

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ER -