The European Society for Blood and Marrow Transplantation (EBMT) Consensus Guidelines for the Detection and Treatment of Donor-specific Anti-HLA Antibodies (DSA) in Haploidentical Hematopoietic Cell Transplantation

Stefan O. Ciurea, Kai Cao, Marcelo Fernadez-Vina, Piyanuch Kongtim, Monzr Al Malki, Ephraim Fuchs, Leo Luznik, Xiao Jun Huang, Fabio Ciceri, Franco Locatelli, Franco Aversa, Luca Castagna, Andrea Bacigalupo, Massimo Martelli, Didier Blaise, Rupert Handgretinger, Denis Claude Roy, Paul O'Donnell, Asad Bashey, Hillard M. LazarusKaren Ballen, Bipin N. Savani, Mohamad Mohty, Arnon Nagler

Research output: Contribution to journalReview article

27 Citations (Scopus)

Abstract

Haploidentical donors are now increasingly considered for transplantation in the absence of HLA-matched donors or when an urgent transplant is needed. Donor-specific anti-HLA antibodies (DSA) have been recently recognized as an important barrier against successful engraftment of donor cells, which can affect transplant survival. DSA appear more prevalent in this type of transplant due to higher likelihood of alloimmunization of multiparous females against offspring's HLA antigens, and the degree of mismatch. Here we summarize the evidence for the role of DSA in the development of primary graft failure in haploidentical transplantation and provide consensus recommendations from the European Society for Blood and Marrow Transplant Group on testing, monitoring, and treatment of patients with DSA receiving haploidentical hematopoietic progenitor cell transplantation.

Original languageEnglish
Pages (from-to)521-534
Number of pages14
JournalBone Marrow Transplantation
Volume53
Issue number5
DOIs
Publication statusPublished - May 1 2018

Fingerprint

Cell Transplantation
Anti-Idiotypic Antibodies
Transplantation
Bone Marrow
Guidelines
Transplants
Therapeutics
Physiologic Monitoring
HLA Antigens
Hematopoietic Stem Cells

ASJC Scopus subject areas

  • Hematology
  • Transplantation

Cite this

The European Society for Blood and Marrow Transplantation (EBMT) Consensus Guidelines for the Detection and Treatment of Donor-specific Anti-HLA Antibodies (DSA) in Haploidentical Hematopoietic Cell Transplantation. / Ciurea, Stefan O.; Cao, Kai; Fernadez-Vina, Marcelo; Kongtim, Piyanuch; Malki, Monzr Al; Fuchs, Ephraim; Luznik, Leo; Huang, Xiao Jun; Ciceri, Fabio; Locatelli, Franco; Aversa, Franco; Castagna, Luca; Bacigalupo, Andrea; Martelli, Massimo; Blaise, Didier; Handgretinger, Rupert; Roy, Denis Claude; O'Donnell, Paul; Bashey, Asad; Lazarus, Hillard M.; Ballen, Karen; Savani, Bipin N.; Mohty, Mohamad; Nagler, Arnon.

In: Bone Marrow Transplantation, Vol. 53, No. 5, 01.05.2018, p. 521-534.

Research output: Contribution to journalReview article

Ciurea, SO, Cao, K, Fernadez-Vina, M, Kongtim, P, Malki, MA, Fuchs, E, Luznik, L, Huang, XJ, Ciceri, F, Locatelli, F, Aversa, F, Castagna, L, Bacigalupo, A, Martelli, M, Blaise, D, Handgretinger, R, Roy, DC, O'Donnell, P, Bashey, A, Lazarus, HM, Ballen, K, Savani, BN, Mohty, M & Nagler, A 2018, 'The European Society for Blood and Marrow Transplantation (EBMT) Consensus Guidelines for the Detection and Treatment of Donor-specific Anti-HLA Antibodies (DSA) in Haploidentical Hematopoietic Cell Transplantation', Bone Marrow Transplantation, vol. 53, no. 5, pp. 521-534. https://doi.org/10.1038/s41409-017-0062-8
Ciurea, Stefan O. ; Cao, Kai ; Fernadez-Vina, Marcelo ; Kongtim, Piyanuch ; Malki, Monzr Al ; Fuchs, Ephraim ; Luznik, Leo ; Huang, Xiao Jun ; Ciceri, Fabio ; Locatelli, Franco ; Aversa, Franco ; Castagna, Luca ; Bacigalupo, Andrea ; Martelli, Massimo ; Blaise, Didier ; Handgretinger, Rupert ; Roy, Denis Claude ; O'Donnell, Paul ; Bashey, Asad ; Lazarus, Hillard M. ; Ballen, Karen ; Savani, Bipin N. ; Mohty, Mohamad ; Nagler, Arnon. / The European Society for Blood and Marrow Transplantation (EBMT) Consensus Guidelines for the Detection and Treatment of Donor-specific Anti-HLA Antibodies (DSA) in Haploidentical Hematopoietic Cell Transplantation. In: Bone Marrow Transplantation. 2018 ; Vol. 53, No. 5. pp. 521-534.
@article{2b1ace3aedd540ffa593442c17694097,
title = "The European Society for Blood and Marrow Transplantation (EBMT) Consensus Guidelines for the Detection and Treatment of Donor-specific Anti-HLA Antibodies (DSA) in Haploidentical Hematopoietic Cell Transplantation",
abstract = "Haploidentical donors are now increasingly considered for transplantation in the absence of HLA-matched donors or when an urgent transplant is needed. Donor-specific anti-HLA antibodies (DSA) have been recently recognized as an important barrier against successful engraftment of donor cells, which can affect transplant survival. DSA appear more prevalent in this type of transplant due to higher likelihood of alloimmunization of multiparous females against offspring's HLA antigens, and the degree of mismatch. Here we summarize the evidence for the role of DSA in the development of primary graft failure in haploidentical transplantation and provide consensus recommendations from the European Society for Blood and Marrow Transplant Group on testing, monitoring, and treatment of patients with DSA receiving haploidentical hematopoietic progenitor cell transplantation.",
author = "Ciurea, {Stefan O.} and Kai Cao and Marcelo Fernadez-Vina and Piyanuch Kongtim and Malki, {Monzr Al} and Ephraim Fuchs and Leo Luznik and Huang, {Xiao Jun} and Fabio Ciceri and Franco Locatelli and Franco Aversa and Luca Castagna and Andrea Bacigalupo and Massimo Martelli and Didier Blaise and Rupert Handgretinger and Roy, {Denis Claude} and Paul O'Donnell and Asad Bashey and Lazarus, {Hillard M.} and Karen Ballen and Savani, {Bipin N.} and Mohamad Mohty and Arnon Nagler",
year = "2018",
month = "5",
day = "1",
doi = "10.1038/s41409-017-0062-8",
language = "English",
volume = "53",
pages = "521--534",
journal = "Bone Marrow Transplantation",
issn = "0268-3369",
publisher = "Nature Publishing Group",
number = "5",

}

TY - JOUR

T1 - The European Society for Blood and Marrow Transplantation (EBMT) Consensus Guidelines for the Detection and Treatment of Donor-specific Anti-HLA Antibodies (DSA) in Haploidentical Hematopoietic Cell Transplantation

AU - Ciurea, Stefan O.

AU - Cao, Kai

AU - Fernadez-Vina, Marcelo

AU - Kongtim, Piyanuch

AU - Malki, Monzr Al

AU - Fuchs, Ephraim

AU - Luznik, Leo

AU - Huang, Xiao Jun

AU - Ciceri, Fabio

AU - Locatelli, Franco

AU - Aversa, Franco

AU - Castagna, Luca

AU - Bacigalupo, Andrea

AU - Martelli, Massimo

AU - Blaise, Didier

AU - Handgretinger, Rupert

AU - Roy, Denis Claude

AU - O'Donnell, Paul

AU - Bashey, Asad

AU - Lazarus, Hillard M.

AU - Ballen, Karen

AU - Savani, Bipin N.

AU - Mohty, Mohamad

AU - Nagler, Arnon

PY - 2018/5/1

Y1 - 2018/5/1

N2 - Haploidentical donors are now increasingly considered for transplantation in the absence of HLA-matched donors or when an urgent transplant is needed. Donor-specific anti-HLA antibodies (DSA) have been recently recognized as an important barrier against successful engraftment of donor cells, which can affect transplant survival. DSA appear more prevalent in this type of transplant due to higher likelihood of alloimmunization of multiparous females against offspring's HLA antigens, and the degree of mismatch. Here we summarize the evidence for the role of DSA in the development of primary graft failure in haploidentical transplantation and provide consensus recommendations from the European Society for Blood and Marrow Transplant Group on testing, monitoring, and treatment of patients with DSA receiving haploidentical hematopoietic progenitor cell transplantation.

AB - Haploidentical donors are now increasingly considered for transplantation in the absence of HLA-matched donors or when an urgent transplant is needed. Donor-specific anti-HLA antibodies (DSA) have been recently recognized as an important barrier against successful engraftment of donor cells, which can affect transplant survival. DSA appear more prevalent in this type of transplant due to higher likelihood of alloimmunization of multiparous females against offspring's HLA antigens, and the degree of mismatch. Here we summarize the evidence for the role of DSA in the development of primary graft failure in haploidentical transplantation and provide consensus recommendations from the European Society for Blood and Marrow Transplant Group on testing, monitoring, and treatment of patients with DSA receiving haploidentical hematopoietic progenitor cell transplantation.

UR - http://www.scopus.com/inward/record.url?scp=85040650217&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=85040650217&partnerID=8YFLogxK

U2 - 10.1038/s41409-017-0062-8

DO - 10.1038/s41409-017-0062-8

M3 - Review article

AN - SCOPUS:85040650217

VL - 53

SP - 521

EP - 534

JO - Bone Marrow Transplantation

JF - Bone Marrow Transplantation

SN - 0268-3369

IS - 5

ER -