The European Society of Thoracic Surgeons (ESTS) lung neuroendocrine tumors (NETs) database

Pier Luigi Filosso, Pierre Emmanuel Falcoz, Paolo Solidoro, Danilo Pellicano, Stefano Passani, Francesco Guerrera, Enrico Ruffini, Caterina Casadio, Ottavio Rena, Paula Moreno Casado, Antonio Alvarez, Dariusz Sagan, Paolo Carbognani, Luca Ampollini, Nizar Asadi, Federico Stella, Mario Nosotti, Luigi Santambrogio, Pascal Alexandre Thomas, Lucile GustCecilia Pompili, Alessandro Brunelli, Stefano Margaritora, Marco Chiappetta, Christian Roesel, Erino Angelo Rendina, Giulio Maurizi, Valentina Larocca, Francesco Ardissone, William D. Travis, Inderpal Sarkaria, Gaetano Rocco

Research output: Contribution to journalReview articlepeer-review


© Journal of Thoracic Disease. All rights reserved. Histological characteristics and clinical behaviour define lung neuroendocrine tumors (NETs), which are classified into four groups: typical (TC) and atypical carcinoids (AC), large-cell neuroendocrine carcinomas (LCNCs) and small-cell lung cancers (SCLCs). Historically, outcome and treatment of these rare neoplasms have been based on small, usually mono-institutional clinical series. Furthermore, their rarity makes quite impossible to design randomised clinical trial to compare different treatments especially in unusual clinical presentations. In 2012, the European Society of Thoracic Surgeons (ESTS) launched a new working-group, specifically dedicated to lung NETs, with the aim to develop modern knowledge on biology and behaviour of these tumors, and to disseminate it within the scientific community. A dedicated retrospective database was at first developed and sent to all the ESTS centres interested to this project. More than 2,000 operated NETs cases have been rapidly collected, and they represented the clinical substrate of several published scientific studies. The retrospective data collection intrinsic limitations in term of patients’ selection and treatment, along with the problem of possible missing data, were the reasons why the ESTS NETs working-group decided in 2015 to design and promote a new prospective database, employing the official ESTS platform. The aim of this review paper is to report the ESTS Lung NETs working-group history and to explain the architecture and use of the lung NETs databases.
Original languageEnglish
Pages (from-to)S3528-S3532
JournalJournal of Thoracic Disease
Publication statusPublished - Oct 1 2018


  • Lung
  • Neuroendocrine tumors (NETs)
  • Outcome
  • Prospective database
  • Retrospective database


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