The EuroPhysiome, STEP and a roadmap for the virtual physiological human

J. W. Fenner, B. Brook, G. Clapworthy, P. V. Coveney, V. Feipel, H. Gregersen, D. R. Hose, P. Kohl, P. Lawford, K. M. McCormack, D. Pinney, S. R. Thomas, S. Van Sint Jan, S. Waters, M. Viceconti

Research output: Contribution to journalArticle

Abstract

Biomedical science and its allied disciplines are entering a new era in which computational methods and technologies are poised to play a prevalent role in supporting collaborative investigation of the human body. Within Europe, this has its focus in the virtual physiological human (VPH), which is an evolving entity that has emerged from the EuroPhysiome initiative and the strategy for the EuroPhysiome (STEP) consortium. The VPH is intended to be a solution to common infrastructure needs for physiome projects across the globe, providing a unifying architecture that facilitates integration and prediction, ultimately creating a framework capable of describing Homo sapiens in silico. The routine reliance of the biomedical industry, biomedical research and clinical practice on information technology (IT) highlights the importance of a tailor-made and robust IT infrastructure, but numerous challenges need to be addressed if the VPH is to become a mature technological reality. Appropriate investment will reap considerable rewards, since it is anticipated that the VPH will influence all sectors of society, with implications predominantly for improved healthcare, improved competitiveness in industry and greater understanding of (patho)physiological processes. This paper considers issues pertinent to the development of the VPH, highlighted by the work of the STEP consortium.

Original languageEnglish
Pages (from-to)2979-2999
Number of pages21
JournalPhilosophical Transactions of the Royal Society A: Mathematical, Physical and Engineering Sciences
Volume366
Issue number1878
DOIs
Publication statusPublished - Sep 13 2008

Keywords

  • EuroPhysiome
  • Integrative biology
  • Physiome
  • Strategy for the EuroPhysiome
  • Virtual physiological human

ASJC Scopus subject areas

  • General
  • Mathematics(all)
  • Physics and Astronomy(all)
  • Engineering(all)

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    Fenner, J. W., Brook, B., Clapworthy, G., Coveney, P. V., Feipel, V., Gregersen, H., Hose, D. R., Kohl, P., Lawford, P., McCormack, K. M., Pinney, D., Thomas, S. R., Van Sint Jan, S., Waters, S., & Viceconti, M. (2008). The EuroPhysiome, STEP and a roadmap for the virtual physiological human. Philosophical Transactions of the Royal Society A: Mathematical, Physical and Engineering Sciences, 366(1878), 2979-2999. https://doi.org/10.1098/rsta.2008.0089