The evidence for late-onset pre-eclampsia as a maternogenic disease of pregnancy

Enrico Ferrazzi, Tamara Stampalija, Jean Edgard Aupont

Research output: Contribution to journalArticle

11 Citations (Scopus)

Abstract

The evidence from biological, clinical and epidemiological studies support the view of different phenotypes of pre-eclampsia: placental, which usually occurs early in pregnancy and is associated with poor early placentation of different severity with subsequent restriction of fetal growth; and maternogenic, which generally occurs late in pregnancy and it is not related to placental insufficiency and fetal growth restriction. This latter condition is associated with low grade chronic inflammation,raised body mass index and frequently relative insulin insensitivity. Unless these distinctions in the disease are acknowledged, clinicians and scientists will continue to try to treat and investigate two phenotypically quite different conditions as if they are one.

Original languageEnglish
Pages (from-to)18-31
Number of pages14
JournalFetal and Maternal Medicine Review
Volume24
Issue number1
DOIs
Publication statusPublished - Feb 2013

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Fetal Development
Pre-Eclampsia
Placental Insufficiency
Placentation
Pregnancy
Epidemiologic Studies
Body Mass Index
Insulin
Inflammation
Phenotype
Clinical Studies

ASJC Scopus subject areas

  • Obstetrics and Gynaecology
  • Pediatrics, Perinatology, and Child Health

Cite this

The evidence for late-onset pre-eclampsia as a maternogenic disease of pregnancy. / Ferrazzi, Enrico; Stampalija, Tamara; Aupont, Jean Edgard.

In: Fetal and Maternal Medicine Review, Vol. 24, No. 1, 02.2013, p. 18-31.

Research output: Contribution to journalArticle

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