The evidence from biological, clinical and epidemiological studies support the view of different phenotypes of pre-eclampsia: placental, which usually occurs early in pregnancy and is associated with poor early placentation of different severity with subsequent restriction of fetal growth; and maternogenic, which generally occurs late in pregnancy and it is not related to placental insufficiency and fetal growth restriction. This latter condition is associated with low grade chronic inflammation,raised body mass index and frequently relative insulin insensitivity. Unless these distinctions in the disease are acknowledged, clinicians and scientists will continue to try to treat and investigate two phenotypically quite different conditions as if they are one.
ASJC Scopus subject areas
- Obstetrics and Gynaecology
- Pediatrics, Perinatology, and Child Health