L'evoluzione della ricerca medica: Dai trial alla terapia personalizzata

Translated title of the contribution: The evolution of medical research: From trials to tailored therapy

Evasio Pasini, Salvatore Pirelli, Andrea Di Lenarda, Francesco S. Dioguardi, Attilio Maseri

Research output: Contribution to journalArticle

1 Citation (Scopus)

Abstract

Medical research and consequently therapy are undergoing dramatic transformation. New science on genomics and proteomics has given us important information on the pathophysiology of many cardiac diseases and personalized responses to specific patient-oriented therapies. The application of cellular genetic and proteome tests is a promising field of research and their clinical use can allow us to both: 1) understand the causes and evolution of heart diseases such as ischemia and heart failure better, 2) lead to personalized medicine. This article focuses on the basic intracellular-related evidence and the unsolved problems and complexity of intracellular signaling that still need to be studied to understand personalized therapies better. In addition, we provide preliminary clinical data that support the potentiality of this new but fundamental approach of curing patients according to their genetic expression and/or protein activation that influence personalized development and the management of cardiovascular diseases.

Original languageItalian
Pages (from-to)761-766
Number of pages6
JournalGiornale Italiano di Cardiologia
Volume11
Issue number10
Publication statusPublished - Oct 2010

Fingerprint

Biomedical Research
Heart Diseases
Precision Medicine
Proteome
Genomics
Proteomics
Cardiovascular Diseases
Therapeutics
Ischemia
Heart Failure
Research
Proteins

ASJC Scopus subject areas

  • Cardiology and Cardiovascular Medicine

Cite this

Pasini, E., Pirelli, S., Di Lenarda, A., Dioguardi, F. S., & Maseri, A. (2010). L'evoluzione della ricerca medica: Dai trial alla terapia personalizzata. Giornale Italiano di Cardiologia, 11(10), 761-766.

L'evoluzione della ricerca medica : Dai trial alla terapia personalizzata. / Pasini, Evasio; Pirelli, Salvatore; Di Lenarda, Andrea; Dioguardi, Francesco S.; Maseri, Attilio.

In: Giornale Italiano di Cardiologia, Vol. 11, No. 10, 10.2010, p. 761-766.

Research output: Contribution to journalArticle

Pasini, E, Pirelli, S, Di Lenarda, A, Dioguardi, FS & Maseri, A 2010, 'L'evoluzione della ricerca medica: Dai trial alla terapia personalizzata', Giornale Italiano di Cardiologia, vol. 11, no. 10, pp. 761-766.
Pasini E, Pirelli S, Di Lenarda A, Dioguardi FS, Maseri A. L'evoluzione della ricerca medica: Dai trial alla terapia personalizzata. Giornale Italiano di Cardiologia. 2010 Oct;11(10):761-766.
Pasini, Evasio ; Pirelli, Salvatore ; Di Lenarda, Andrea ; Dioguardi, Francesco S. ; Maseri, Attilio. / L'evoluzione della ricerca medica : Dai trial alla terapia personalizzata. In: Giornale Italiano di Cardiologia. 2010 ; Vol. 11, No. 10. pp. 761-766.
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