Abstract
Objectives: We performed a systematic literature review of the staging of pelvic lymph node metastases in clinically localized prostate cancer. Methods: The description of the evolution of the staging paradigms of lymph node invasion (LNI) in localized prostate cancer is based on a systematic review of the English language literature on this topic. Results: A single randomized trial addressing pelvic lymph node dissection (PLND) exists and no Cochrane review covers the topic of lymph node staging in localized prostate cancer. Most publications are based on retrospective analyses, including some large multicenter validation studies. The available reports demonstrate that extended PLND improves staging and that ideally 30 lymph nodes should be removed. This represents a shift away from either no PLND or very limited PLND, in historic series. However, not all men need to be subjected to an extended PLND. At least some patients can be effectively staged with limited PLND. Conclusions: This review illustrates the evolution of lymph node staging in prostate cancer, which changed from no staging through limited staging to extended staging. This review provides evidence-based criteria for identifying patients at risk of LNI, as well as for defining the extent of PLND, when indicated.
| Original language | English |
|---|---|
| Pages (from-to) | 153-162 |
| Number of pages | 10 |
| Journal | EAU-EBU Update Series |
| Volume | 5 |
| Issue number | 4 |
| DOIs | |
| Publication status | Published - Aug 2007 |
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Keywords
- Complications
- Lymph node invasion
- Pelvic lymphadenectomy
- Prostate cancer
- Radical prostatectomy
ASJC Scopus subject areas
- Urology
Cite this
The Evolution of Staging of Lymph Node Metastases in Clinically Localized Prostate Cancer{A figure is presented}. / Hutterer, Georg C.; Briganti, Alberto; Chun, F. K H; Gallina, Andrea; Rigatti, Patrizio; Montorsi, Francesco; Karakiewicz, Pierre I.
In: EAU-EBU Update Series, Vol. 5, No. 4, 08.2007, p. 153-162.Research output: Contribution to journal › Article
}
TY - JOUR
T1 - The Evolution of Staging of Lymph Node Metastases in Clinically Localized Prostate Cancer{A figure is presented}
AU - Hutterer, Georg C.
AU - Briganti, Alberto
AU - Chun, F. K H
AU - Gallina, Andrea
AU - Rigatti, Patrizio
AU - Montorsi, Francesco
AU - Karakiewicz, Pierre I.
PY - 2007/8
Y1 - 2007/8
N2 - Objectives: We performed a systematic literature review of the staging of pelvic lymph node metastases in clinically localized prostate cancer. Methods: The description of the evolution of the staging paradigms of lymph node invasion (LNI) in localized prostate cancer is based on a systematic review of the English language literature on this topic. Results: A single randomized trial addressing pelvic lymph node dissection (PLND) exists and no Cochrane review covers the topic of lymph node staging in localized prostate cancer. Most publications are based on retrospective analyses, including some large multicenter validation studies. The available reports demonstrate that extended PLND improves staging and that ideally 30 lymph nodes should be removed. This represents a shift away from either no PLND or very limited PLND, in historic series. However, not all men need to be subjected to an extended PLND. At least some patients can be effectively staged with limited PLND. Conclusions: This review illustrates the evolution of lymph node staging in prostate cancer, which changed from no staging through limited staging to extended staging. This review provides evidence-based criteria for identifying patients at risk of LNI, as well as for defining the extent of PLND, when indicated.
AB - Objectives: We performed a systematic literature review of the staging of pelvic lymph node metastases in clinically localized prostate cancer. Methods: The description of the evolution of the staging paradigms of lymph node invasion (LNI) in localized prostate cancer is based on a systematic review of the English language literature on this topic. Results: A single randomized trial addressing pelvic lymph node dissection (PLND) exists and no Cochrane review covers the topic of lymph node staging in localized prostate cancer. Most publications are based on retrospective analyses, including some large multicenter validation studies. The available reports demonstrate that extended PLND improves staging and that ideally 30 lymph nodes should be removed. This represents a shift away from either no PLND or very limited PLND, in historic series. However, not all men need to be subjected to an extended PLND. At least some patients can be effectively staged with limited PLND. Conclusions: This review illustrates the evolution of lymph node staging in prostate cancer, which changed from no staging through limited staging to extended staging. This review provides evidence-based criteria for identifying patients at risk of LNI, as well as for defining the extent of PLND, when indicated.
KW - Complications
KW - Lymph node invasion
KW - Pelvic lymphadenectomy
KW - Prostate cancer
KW - Radical prostatectomy
UR - http://www.scopus.com/inward/record.url?scp=34250630581&partnerID=8YFLogxK
UR - http://www.scopus.com/inward/citedby.url?scp=34250630581&partnerID=8YFLogxK
U2 - 10.1016/j.eeus.2007.04.003
DO - 10.1016/j.eeus.2007.04.003
M3 - Article
AN - SCOPUS:34250630581
VL - 5
SP - 153
EP - 162
JO - EAU-EBU Update Series
JF - EAU-EBU Update Series
SN - 1871-2592
IS - 4
ER -