TY - JOUR
T1 - The evolution of the epidemiological landscape of head and neck cancer in Italy
T2 - Is there evidence for an increase in the incidence of potentially HPV-related carcinomas?
AU - AIRTUM Working Group
AU - Boscolo-Rizzo, Paolo
AU - Zorzi, Manuel
AU - Del Mistro, Annarosa
AU - Da Mosto, Maria Cristina
AU - Tirelli, Giancarlo
AU - Buzzoni, Carlotta
AU - Rugge, Massimo
AU - Polesel, Jerry
AU - Guzzinati, Stefano
PY - 2018
Y1 - 2018
N2 - The current study aimed to investigate the incidence and survival patterns of HNSCCs arising from different anatomic sites, potentially related (the oropharynx) or unrelated (the oral cavity, the larynx/hypopharynx) to HPV, to provide clues on possible growing impact of HPV in the epidemiology of HNSCC in Italy. Epidemiological data were retrieved from ten long-term Cancer Registries covering a population of 7.8 million inhabitants. Trends were described by means of the estimated annual percent change (APC) stratified by age and gender, and compared between HPV-related and HPV-unrelated anatomical sites. The data regarding 28,295 HNSCCs diagnosed in Italy between 1988 and 2012 were analyzed. In males, the incidence rate (IR) of cancers arising from sites unrelated to HPV infection significantly decreased in all age groups (APC:-3.31 for larynx/hypopharynx; APC:-1.77 for oral cavity), whereas stable IR were observed for cancers arising from sites related to HPV infection. In females, IR for cancers from HPV-related sites increased significantly over the observed period; the largest increment was noted in those over 60 (APC:2.92%) who also showed a significantly lower number of HNSCCs from the larynx/hypopharynx (APC:- 0.84) and a significantly higher number of oral cavity tumors (APC = 2.15). The five-year relative survival remained largely unchanged in the patients with laryngeal/hypopharyngeal SCC and, conversely, significantly improved in the patients with SCC at HPV-related sites. The trends observed suggest a potential increasing impact of HPV infection on the epidemiology of HNSCC in Italy, but to a lesser extent and with a different pattern from that observed in other Western countries.
AB - The current study aimed to investigate the incidence and survival patterns of HNSCCs arising from different anatomic sites, potentially related (the oropharynx) or unrelated (the oral cavity, the larynx/hypopharynx) to HPV, to provide clues on possible growing impact of HPV in the epidemiology of HNSCC in Italy. Epidemiological data were retrieved from ten long-term Cancer Registries covering a population of 7.8 million inhabitants. Trends were described by means of the estimated annual percent change (APC) stratified by age and gender, and compared between HPV-related and HPV-unrelated anatomical sites. The data regarding 28,295 HNSCCs diagnosed in Italy between 1988 and 2012 were analyzed. In males, the incidence rate (IR) of cancers arising from sites unrelated to HPV infection significantly decreased in all age groups (APC:-3.31 for larynx/hypopharynx; APC:-1.77 for oral cavity), whereas stable IR were observed for cancers arising from sites related to HPV infection. In females, IR for cancers from HPV-related sites increased significantly over the observed period; the largest increment was noted in those over 60 (APC:2.92%) who also showed a significantly lower number of HNSCCs from the larynx/hypopharynx (APC:- 0.84) and a significantly higher number of oral cavity tumors (APC = 2.15). The five-year relative survival remained largely unchanged in the patients with laryngeal/hypopharyngeal SCC and, conversely, significantly improved in the patients with SCC at HPV-related sites. The trends observed suggest a potential increasing impact of HPV infection on the epidemiology of HNSCC in Italy, but to a lesser extent and with a different pattern from that observed in other Western countries.
KW - Adult
KW - Aged
KW - Alphapapillomavirus/isolation & purification
KW - Carcinoma, Squamous Cell/epidemiology
KW - Female
KW - Head and Neck Neoplasms/epidemiology
KW - Humans
KW - Incidence
KW - Italy/epidemiology
KW - Male
KW - Middle Aged
KW - Registries
KW - Squamous Cell Carcinoma of Head and Neck
KW - Survival Analysis
KW - Tumor Virus Infections/epidemiology
U2 - 10.1371/journal.pone.0192621
DO - 10.1371/journal.pone.0192621
M3 - Article
C2 - 29415020
VL - 13
SP - e0192621
JO - PLoS One
JF - PLoS One
SN - 1932-6203
IS - 2
ER -