The evolutionary scenario of hepatocellular carcinoma in Italy: an update

Laura Bucci, Francesca Garuti, Barbara Lenzi, Anna Pecorelli, Fabio Farinati, Edoardo G. Giannini, Alessandro Granito, Francesca Ciccarese, Gian Lodovico Rapaccini, Maria De Marco, Eugenio Caturelli, Marco Zoli, Franco Borzio, Rodolfo Sacco, Calogero Cammà, Roberto Virdone, Fabio Marra, Martina Felder, Filomena Morisco, Luisa BenvegnùAntonio Gasbarrini, Gianluca Svegliati Baroni, Francesco Giuseppe Foschi, Gabriele Missale, Alberto Masotto, Gerardo Nardone, Antonio Colecchia, Mauro Bernardi, Franco Trevisani

Research output: Contribution to journalArticle

Abstract

Background & Aims: Epidemiology of hepatocellular carcinoma is changing worldwide. This study aimed at evaluating the changing scenario of aetiology, presentation, management and prognosis of hepatocellular carcinoma in Italy during the last 15 years. Methods: Retrospective analysis of the ITA.LI.CA (Italian Liver Cancer) database including 5192 hepatocellular carcinoma patients managed in 24 centres from 2000 to 2014. Patients were divided into three groups according to the date of cancer diagnosis (2000–2004, 2005–2009 and 2010–2014). Results: The main results were as follows: (i) progressive patient aging; (ii) progressive expansion of non-viral cases and, namely, of “metabolic” hepatocellular carcinomas; (iii) increasing proportion of hepatocellular carcinoma diagnosed during a correct (semi-annual) surveillance programme; (iv) favourable cancer stage migration; (v) increased use of radiofrequency ablation to the detriment of percutaneous ethanol injection; (vi) improved outcomes of ablative and transarterial treatments; (vii) improved overall survival (adjusted for the lead time in surveyed patients), particularly after 2009, of both viral and non-viral patients presenting with an early- or intermediate-stage hepatocellular carcinoma. Conclusions: During the last 15 years several aetiological and clinical features of hepatocellular carcinoma patients have changed, as their management. The observed improvement of overall survival was owing both to the wider use of semi-annual surveillance, expanding the proportion of tumours that qualified for curative treatments, and to the improved outcome of loco-regional treatments.

Original languageEnglish
JournalLiver International
DOIs
Publication statusE-pub ahead of print - Jul 18 2016

Fingerprint

Italy
Hepatocellular Carcinoma
Neoplasms
Survival
Liver Neoplasms
Epidemiology
Ethanol
Therapeutics
Databases
Injections

Keywords

  • epidemiology
  • hepatocellular carcinoma
  • survival
  • treatment

ASJC Scopus subject areas

  • Hepatology

Cite this

The evolutionary scenario of hepatocellular carcinoma in Italy : an update. / Bucci, Laura; Garuti, Francesca; Lenzi, Barbara; Pecorelli, Anna; Farinati, Fabio; Giannini, Edoardo G.; Granito, Alessandro; Ciccarese, Francesca; Rapaccini, Gian Lodovico; De Marco, Maria; Caturelli, Eugenio; Zoli, Marco; Borzio, Franco; Sacco, Rodolfo; Cammà, Calogero; Virdone, Roberto; Marra, Fabio; Felder, Martina; Morisco, Filomena; Benvegnù, Luisa; Gasbarrini, Antonio; Svegliati Baroni, Gianluca; Foschi, Francesco Giuseppe; Missale, Gabriele; Masotto, Alberto; Nardone, Gerardo; Colecchia, Antonio; Bernardi, Mauro; Trevisani, Franco.

In: Liver International, 18.07.2016.

Research output: Contribution to journalArticle

Bucci, L, Garuti, F, Lenzi, B, Pecorelli, A, Farinati, F, Giannini, EG, Granito, A, Ciccarese, F, Rapaccini, GL, De Marco, M, Caturelli, E, Zoli, M, Borzio, F, Sacco, R, Cammà, C, Virdone, R, Marra, F, Felder, M, Morisco, F, Benvegnù, L, Gasbarrini, A, Svegliati Baroni, G, Foschi, FG, Missale, G, Masotto, A, Nardone, G, Colecchia, A, Bernardi, M & Trevisani, F 2016, 'The evolutionary scenario of hepatocellular carcinoma in Italy: an update', Liver International. https://doi.org/10.1111/liv.13204
Bucci, Laura ; Garuti, Francesca ; Lenzi, Barbara ; Pecorelli, Anna ; Farinati, Fabio ; Giannini, Edoardo G. ; Granito, Alessandro ; Ciccarese, Francesca ; Rapaccini, Gian Lodovico ; De Marco, Maria ; Caturelli, Eugenio ; Zoli, Marco ; Borzio, Franco ; Sacco, Rodolfo ; Cammà, Calogero ; Virdone, Roberto ; Marra, Fabio ; Felder, Martina ; Morisco, Filomena ; Benvegnù, Luisa ; Gasbarrini, Antonio ; Svegliati Baroni, Gianluca ; Foschi, Francesco Giuseppe ; Missale, Gabriele ; Masotto, Alberto ; Nardone, Gerardo ; Colecchia, Antonio ; Bernardi, Mauro ; Trevisani, Franco. / The evolutionary scenario of hepatocellular carcinoma in Italy : an update. In: Liver International. 2016.
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abstract = "Background & Aims: Epidemiology of hepatocellular carcinoma is changing worldwide. This study aimed at evaluating the changing scenario of aetiology, presentation, management and prognosis of hepatocellular carcinoma in Italy during the last 15 years. Methods: Retrospective analysis of the ITA.LI.CA (Italian Liver Cancer) database including 5192 hepatocellular carcinoma patients managed in 24 centres from 2000 to 2014. Patients were divided into three groups according to the date of cancer diagnosis (2000–2004, 2005–2009 and 2010–2014). Results: The main results were as follows: (i) progressive patient aging; (ii) progressive expansion of non-viral cases and, namely, of “metabolic” hepatocellular carcinomas; (iii) increasing proportion of hepatocellular carcinoma diagnosed during a correct (semi-annual) surveillance programme; (iv) favourable cancer stage migration; (v) increased use of radiofrequency ablation to the detriment of percutaneous ethanol injection; (vi) improved outcomes of ablative and transarterial treatments; (vii) improved overall survival (adjusted for the lead time in surveyed patients), particularly after 2009, of both viral and non-viral patients presenting with an early- or intermediate-stage hepatocellular carcinoma. Conclusions: During the last 15 years several aetiological and clinical features of hepatocellular carcinoma patients have changed, as their management. The observed improvement of overall survival was owing both to the wider use of semi-annual surveillance, expanding the proportion of tumours that qualified for curative treatments, and to the improved outcome of loco-regional treatments.",
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AU - Bucci, Laura

AU - Garuti, Francesca

AU - Lenzi, Barbara

AU - Pecorelli, Anna

AU - Farinati, Fabio

AU - Giannini, Edoardo G.

AU - Granito, Alessandro

AU - Ciccarese, Francesca

AU - Rapaccini, Gian Lodovico

AU - De Marco, Maria

AU - Caturelli, Eugenio

AU - Zoli, Marco

AU - Borzio, Franco

AU - Sacco, Rodolfo

AU - Cammà, Calogero

AU - Virdone, Roberto

AU - Marra, Fabio

AU - Felder, Martina

AU - Morisco, Filomena

AU - Benvegnù, Luisa

AU - Gasbarrini, Antonio

AU - Svegliati Baroni, Gianluca

AU - Foschi, Francesco Giuseppe

AU - Missale, Gabriele

AU - Masotto, Alberto

AU - Nardone, Gerardo

AU - Colecchia, Antonio

AU - Bernardi, Mauro

AU - Trevisani, Franco

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N2 - Background & Aims: Epidemiology of hepatocellular carcinoma is changing worldwide. This study aimed at evaluating the changing scenario of aetiology, presentation, management and prognosis of hepatocellular carcinoma in Italy during the last 15 years. Methods: Retrospective analysis of the ITA.LI.CA (Italian Liver Cancer) database including 5192 hepatocellular carcinoma patients managed in 24 centres from 2000 to 2014. Patients were divided into three groups according to the date of cancer diagnosis (2000–2004, 2005–2009 and 2010–2014). Results: The main results were as follows: (i) progressive patient aging; (ii) progressive expansion of non-viral cases and, namely, of “metabolic” hepatocellular carcinomas; (iii) increasing proportion of hepatocellular carcinoma diagnosed during a correct (semi-annual) surveillance programme; (iv) favourable cancer stage migration; (v) increased use of radiofrequency ablation to the detriment of percutaneous ethanol injection; (vi) improved outcomes of ablative and transarterial treatments; (vii) improved overall survival (adjusted for the lead time in surveyed patients), particularly after 2009, of both viral and non-viral patients presenting with an early- or intermediate-stage hepatocellular carcinoma. Conclusions: During the last 15 years several aetiological and clinical features of hepatocellular carcinoma patients have changed, as their management. The observed improvement of overall survival was owing both to the wider use of semi-annual surveillance, expanding the proportion of tumours that qualified for curative treatments, and to the improved outcome of loco-regional treatments.

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