L'esclusione degli anziani dai trial clinici sullo scompenso cardiaco: Cause e conseguenze

Translated title of the contribution: The exclusion of older patients from clinical trials regarding heart failure. Causes and consequences

Antonio Cherubini, Annarita Cerenzia, Elisa Zengarini

Research output: Contribution to journalArticlepeer-review

Abstract

Older subjects are commonly excluded from clinical trials, that are the gold standard to assess the efficacy and safety of new drugs and non pharmacological therapies. The consequence is the lack of evidence about the optimal drug therapy in this population, who makes the highest consumption of drugs, with increased risk of adverse reactions and undertreatment. A clear example is heart failure: data obtained in the context of the European Project PREDICT confirm a widespread exclusion of older individuals from ongoing clinical trials in heart failure, despite the recommendations of regulatory agencies.

Translated title of the contributionThe exclusion of older patients from clinical trials regarding heart failure. Causes and consequences
Original languageItalian
Pages (from-to)103-108
Number of pages6
JournalRecenti Progressi in Medicina
Volume103
Issue number3
DOIs
Publication statusPublished - Mar 2012

ASJC Scopus subject areas

  • Medicine(all)

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