The expanding role of predictive toxicology: An update on the (Q)SAR models for mutagens and carcinogens

Romualdo Benigni, Tatiana I. Netzeva, Emilio Benfenati, Cecilia Bossa, Rainer Franke, Christoph Helma, Etje Hulzebos, Carol Marchant, Ann Richard, Yin Tak Woo, Chihae Yang

Research output: Contribution to journalArticle

Abstract

Different regulatory schemes worldwide, and in particular, the preparation for the new REACH (Registration, Evaluation and Authorization of CHemicals) legislation in Europe, increase the reliance on estimation methods for predicting potential chemical hazard. To meet the increased expectations, the availability of valid (Q)SARs becomes a critical issue, especially for endpoints that have complex mechanisms of action, are time-and cost-consuming, and require a large number of animals to test. Here, findings from the survey on (Q)SARs for mutagenicity and carcinogenicity, initiated by the European Chemicals Bureau (ECB) and carried out by the Istituto Superiore di Sanita' are summarized, key aspects are discussed, and a broader view towards future needs and perspectives is given.

Original languageEnglish
Pages (from-to)53-97
Number of pages45
JournalJournal of Environmental Science and Health - Part C Environmental Carcinogenesis and Ecotoxicology Reviews
Volume25
Issue number1
DOIs
Publication statusPublished - Jan 2007

ASJC Scopus subject areas

  • Environmental Science(all)
  • Environmental Chemistry
  • Oncology
  • Cancer Research
  • Toxicology
  • Health, Toxicology and Mutagenesis

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