The expanding role of predictive toxicology

An update on the (Q)SAR models for mutagens and carcinogens

Romualdo Benigni, Tatiana I. Netzeva, Emilio Benfenati, Cecilia Bossa, Rainer Franke, Christoph Helma, Etje Hulzebos, Carol Marchant, Ann Richard, Yin Tak Woo, Chihae Yang

Research output: Contribution to journalArticle

83 Citations (Scopus)

Abstract

Different regulatory schemes worldwide, and in particular, the preparation for the new REACH (Registration, Evaluation and Authorization of CHemicals) legislation in Europe, increase the reliance on estimation methods for predicting potential chemical hazard. To meet the increased expectations, the availability of valid (Q)SARs becomes a critical issue, especially for endpoints that have complex mechanisms of action, are time-and cost-consuming, and require a large number of animals to test. Here, findings from the survey on (Q)SARs for mutagenicity and carcinogenicity, initiated by the European Chemicals Bureau (ECB) and carried out by the Istituto Superiore di Sanita' are summarized, key aspects are discussed, and a broader view towards future needs and perspectives is given.

Original languageEnglish
Pages (from-to)53-97
Number of pages45
JournalJournal of Environmental Science and Health - Part C Environmental Carcinogenesis and Ecotoxicology Reviews
Volume25
Issue number1
DOIs
Publication statusPublished - Jan 2007

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Mutagens
toxicology
carcinogen
Legislation
Carcinogens
Toxicology
synthetic aperture radar
Chemical hazards
Costs and Cost Analysis
Animals
mutagenicity
Availability
estimation method
legislation
hazard
Costs
animal
cost
mutagen
chemical

ASJC Scopus subject areas

  • Environmental Science(all)
  • Environmental Chemistry
  • Oncology
  • Cancer Research
  • Toxicology
  • Health, Toxicology and Mutagenesis

Cite this

The expanding role of predictive toxicology : An update on the (Q)SAR models for mutagens and carcinogens. / Benigni, Romualdo; Netzeva, Tatiana I.; Benfenati, Emilio; Bossa, Cecilia; Franke, Rainer; Helma, Christoph; Hulzebos, Etje; Marchant, Carol; Richard, Ann; Woo, Yin Tak; Yang, Chihae.

In: Journal of Environmental Science and Health - Part C Environmental Carcinogenesis and Ecotoxicology Reviews, Vol. 25, No. 1, 01.2007, p. 53-97.

Research output: Contribution to journalArticle

Benigni, Romualdo ; Netzeva, Tatiana I. ; Benfenati, Emilio ; Bossa, Cecilia ; Franke, Rainer ; Helma, Christoph ; Hulzebos, Etje ; Marchant, Carol ; Richard, Ann ; Woo, Yin Tak ; Yang, Chihae. / The expanding role of predictive toxicology : An update on the (Q)SAR models for mutagens and carcinogens. In: Journal of Environmental Science and Health - Part C Environmental Carcinogenesis and Ecotoxicology Reviews. 2007 ; Vol. 25, No. 1. pp. 53-97.
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