The exploitation of distinct recognition receptors in dendritic cells determines the full range of host immune relationships with Candida albicans

Luigina Romani, Claudia Montagnoli, Silvia Bozza, Katia Perruccio, Antonio Spreca, Paola Allavena, Sjef Verbeek, Richard A. Calderone, Francesco Bistoni, Paolo Puccetti

Research output: Contribution to journalArticlepeer-review

Abstract

Dendritic cells (DC) sense saprophytic yeast and pathogenic, filamentous forms of Candida albicans in a specific way, resulting in disparate patterns of DC and Th cell activation. Using human and murine DC, such disparate patterns could be traced to the exploitation of distinct recognition receptors. Although usage of mannose receptors led to protective type 1 responses in mice, entry through Fcγ receptors was responsible for suppression of mannose receptor-dependent reactivity, onset of type 2 responses and associated pathology. As the usage of distinct receptors selectively occurred with yeast or hyphal forms of the fungus, these findings suggest that the responsibility for pathogenicity of C. albicans is shared by the organism and DC, with implications for fungal virulence, immunity and vaccine development.

Original languageEnglish
Pages (from-to)149-161
Number of pages13
JournalInternational Immunology
Volume16
Issue number1
DOIs
Publication statusPublished - Jan 2004

Keywords

  • Candida albicans
  • Dendritic cell
  • Dimorphism
  • Receptor
  • T

ASJC Scopus subject areas

  • Immunology

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