The expression of genes of the steroid-thyroid hormone receptor superfamily in central nervous system tumors

L. Magrassi, G. Butti, E. Silini, F. Bono, P. Paoletti, G. Milanesi

Research output: Contribution to journalArticlepeer-review

Abstract

We studied the expression of ten genes (encoding the receptors for glucocorticoid, mineralocorticoid, progesterone, androgen, estrogen, thyroid, retinoid acid, vitamin D) belonging to the steroid-thyroid hormone receptor superfamily (STRS) in 12 neuroepithelial tumors, 12 meningiomas and 2 human glioblastoma cell lines. Our method, based on the polymerase chain reaction, allowed the simultaneous amplification of cDNAs of the STRS genes. On average, 7 STRS genes were simultaneously expressed in each sample. Our study indicates that many STRS genes are commonly coexpressed in human CNS tumors. The importance of our results for the ongoing and proposed hormonal treatment trials is discussed.

Original languageEnglish
Pages (from-to)859-866
Number of pages8
JournalAnticancer Research
Volume13
Issue number4
Publication statusPublished - 1993

Keywords

  • Brain tumors
  • Gene expression
  • Hormonal therapy
  • Polymerase chain reaction
  • Steroid-thyroid receptor superfamily

ASJC Scopus subject areas

  • Cancer Research
  • Oncology

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