Abstract
High Mobility Group I (HMGI) proteins are nuclear proteins involved in the regulation of chromatin structure and function. Elevated expression of the HMGI proteins (HMGI, HMGY and HMGI-C) has been correlated with the presence of a highly malignant phenotype in epithelial and fibroblastic rat thyroid cells, and in several experimental carcinomas. Here, we demonstrate that HMGI and HMGY proteins are expressed in human thyroid carcinomas and thyroid carcinoma cell lines, but not in adenomas, goiters, normal thyroid tissues and cells, These results indicate a correlation between HMGI and HMGY expression and the malignant phenotype of thyroid neoplasias, suggesting that these proteins may be used as markers in thyroid cancer.
| Original language | English |
|---|---|
| Pages (from-to) | 1307-1314 |
| Number of pages | 8 |
| Journal | Oncogene |
| Volume | 10 |
| Issue number | 7 |
| Publication status | Published - 1995 |
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Keywords
- Carcinomas
- HMGI (Y) proteins
- Immunohistochemistry
- Thyroid
- Tumor marker
ASJC Scopus subject areas
- Cancer Research
- Genetics
- Molecular Biology
Cite this
Chiappetta, G., Bandiera, A., Berlingieri, M. T., Visconti, R., Manfioletti, G., Battista, S., Martinez-Tello, F. J., Santoro, M., Giancotti, V., & Fusco, A. (1995). The expression of the high mobility group HMGI (Y) proteins correlates with the malignant phenotype of human thyroid neoplasias. Oncogene, 10(7), 1307-1314.