The expression of the high mobility group HMGI (Y) proteins correlates with the malignant phenotype of human thyroid neoplasias

G. Chiappetta; A. Bandiera; M. T. Berlingieri; R. Visconti; G. Manfioletti; S. Battista; F. J. Martinez-Tello; M. Santoro; V. Giancotti; A. Fusco

The expression of the high mobility group HMGI (Y) proteins correlates with the malignant phenotype of human thyroid neoplasias

G. Chiappetta, A. Bandiera, M. T. Berlingieri, R. Visconti, G. Manfioletti, S. Battista, F. J. Martinez-Tello, M. Santoro, V. Giancotti, A. Fusco

Istituto Nazionale Tumori Fondazione G. Pascale

Research output: Contribution to journal › Article › peer-review

Abstract

High Mobility Group I (HMGI) proteins are nuclear proteins involved in the regulation of chromatin structure and function. Elevated expression of the HMGI proteins (HMGI, HMGY and HMGI-C) has been correlated with the presence of a highly malignant phenotype in epithelial and fibroblastic rat thyroid cells, and in several experimental carcinomas. Here, we demonstrate that HMGI and HMGY proteins are expressed in human thyroid carcinomas and thyroid carcinoma cell lines, but not in adenomas, goiters, normal thyroid tissues and cells, These results indicate a correlation between HMGI and HMGY expression and the malignant phenotype of thyroid neoplasias, suggesting that these proteins may be used as markers in thyroid cancer.

Original language	English
Pages (from-to)	1307-1314
Number of pages	8
Journal	Oncogene
Volume	10
Issue number	7
Publication status	Published - 1995

Keywords

Carcinomas
HMGI (Y) proteins
Immunohistochemistry
Thyroid
Tumor marker

ASJC Scopus subject areas

Cancer Research
Genetics
Molecular Biology

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The expression of the high mobility group HMGI (Y) proteins correlates with the malignant phenotype of human thyroid neoplasias. / Chiappetta, G.; Bandiera, A.; Berlingieri, M. T.; Visconti, R.; Manfioletti, G.; Battista, S.; Martinez-Tello, F. J.; Santoro, M.; Giancotti, V.; Fusco, A.

In: Oncogene, Vol. 10, No. 7, 1995, p. 1307-1314.

Research output: Contribution to journal › Article › peer-review

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abstract = "High Mobility Group I (HMGI) proteins are nuclear proteins involved in the regulation of chromatin structure and function. Elevated expression of the HMGI proteins (HMGI, HMGY and HMGI-C) has been correlated with the presence of a highly malignant phenotype in epithelial and fibroblastic rat thyroid cells, and in several experimental carcinomas. Here, we demonstrate that HMGI and HMGY proteins are expressed in human thyroid carcinomas and thyroid carcinoma cell lines, but not in adenomas, goiters, normal thyroid tissues and cells, These results indicate a correlation between HMGI and HMGY expression and the malignant phenotype of thyroid neoplasias, suggesting that these proteins may be used as markers in thyroid cancer.",

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AU - Chiappetta, G.

AU - Bandiera, A.

AU - Berlingieri, M. T.

AU - Visconti, R.

AU - Manfioletti, G.

AU - Battista, S.

AU - Martinez-Tello, F. J.

AU - Santoro, M.

AU - Giancotti, V.

AU - Fusco, A.

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AB - High Mobility Group I (HMGI) proteins are nuclear proteins involved in the regulation of chromatin structure and function. Elevated expression of the HMGI proteins (HMGI, HMGY and HMGI-C) has been correlated with the presence of a highly malignant phenotype in epithelial and fibroblastic rat thyroid cells, and in several experimental carcinomas. Here, we demonstrate that HMGI and HMGY proteins are expressed in human thyroid carcinomas and thyroid carcinoma cell lines, but not in adenomas, goiters, normal thyroid tissues and cells, These results indicate a correlation between HMGI and HMGY expression and the malignant phenotype of thyroid neoplasias, suggesting that these proteins may be used as markers in thyroid cancer.

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