The extracellular matrix of the lung and airway responsiveness in asthma

Francesco G. Salerno, M. P Foschino Barbaro, O. Toungoussova, E. Carpagnano, P. Guido, A. Spanevello

Research output: Contribution to journalArticle

3 Citations (Scopus)

Abstract

The extracellular matrix is the main determinant of the structure and of mechanical behaviour of the lung. The extracellular matrix is also responsible for the mechanical interdependence between airway and parenchyma due to the alveolar attachments to the airways. Asthma is characterized by bronchial hyperresponsiveness, airway remodelling and inflammation, and an altered extracellular matrix may play a role in all these functional and structural abnormalities. The excessive airway narrowing observed in asthma may be related to the altered viscoelastic properties of lung parenchyma and airway wall, determining a decrease in the mechanical load opposing the airways' smooth muscle contraction. Indeed, an altered extracellular matrix deposition in asthma in humans, has been demonstrated. In addition, in the asthmatic lung, the matrix seems to contribute to airway inflammation, airway remodelling, and to those alterations of the smooth muscle function of the airway and morphology typical of asthma.

Original languageEnglish
Pages (from-to)27-30
Number of pages4
JournalMonaldi Archives for Chest Disease - Cardiac Series
Volume71
Issue number1
Publication statusPublished - Mar 2009

Fingerprint

Extracellular Matrix
Asthma
Airway Remodeling
Lung
Smooth Muscle
Inflammation
Muscle Contraction

Keywords

  • Airway remodelling
  • Airway smooth muscle
  • Decorin
  • Protgeiglycan

ASJC Scopus subject areas

  • Pulmonary and Respiratory Medicine

Cite this

The extracellular matrix of the lung and airway responsiveness in asthma. / Salerno, Francesco G.; Barbaro, M. P Foschino; Toungoussova, O.; Carpagnano, E.; Guido, P.; Spanevello, A.

In: Monaldi Archives for Chest Disease - Cardiac Series, Vol. 71, No. 1, 03.2009, p. 27-30.

Research output: Contribution to journalArticle

Salerno, Francesco G. ; Barbaro, M. P Foschino ; Toungoussova, O. ; Carpagnano, E. ; Guido, P. ; Spanevello, A. / The extracellular matrix of the lung and airway responsiveness in asthma. In: Monaldi Archives for Chest Disease - Cardiac Series. 2009 ; Vol. 71, No. 1. pp. 27-30.
@article{e4cd2a18b8844cbebb0a530312d47583,
title = "The extracellular matrix of the lung and airway responsiveness in asthma",
abstract = "The extracellular matrix is the main determinant of the structure and of mechanical behaviour of the lung. The extracellular matrix is also responsible for the mechanical interdependence between airway and parenchyma due to the alveolar attachments to the airways. Asthma is characterized by bronchial hyperresponsiveness, airway remodelling and inflammation, and an altered extracellular matrix may play a role in all these functional and structural abnormalities. The excessive airway narrowing observed in asthma may be related to the altered viscoelastic properties of lung parenchyma and airway wall, determining a decrease in the mechanical load opposing the airways' smooth muscle contraction. Indeed, an altered extracellular matrix deposition in asthma in humans, has been demonstrated. In addition, in the asthmatic lung, the matrix seems to contribute to airway inflammation, airway remodelling, and to those alterations of the smooth muscle function of the airway and morphology typical of asthma.",
keywords = "Airway remodelling, Airway smooth muscle, Decorin, Protgeiglycan",
author = "Salerno, {Francesco G.} and Barbaro, {M. P Foschino} and O. Toungoussova and E. Carpagnano and P. Guido and A. Spanevello",
year = "2009",
month = "3",
language = "English",
volume = "71",
pages = "27--30",
journal = "Monaldi Archives for Chest Disease",
issn = "1122-0643",
publisher = "Fondazione Salvatore Maugeri",
number = "1",

}

TY - JOUR

T1 - The extracellular matrix of the lung and airway responsiveness in asthma

AU - Salerno, Francesco G.

AU - Barbaro, M. P Foschino

AU - Toungoussova, O.

AU - Carpagnano, E.

AU - Guido, P.

AU - Spanevello, A.

PY - 2009/3

Y1 - 2009/3

N2 - The extracellular matrix is the main determinant of the structure and of mechanical behaviour of the lung. The extracellular matrix is also responsible for the mechanical interdependence between airway and parenchyma due to the alveolar attachments to the airways. Asthma is characterized by bronchial hyperresponsiveness, airway remodelling and inflammation, and an altered extracellular matrix may play a role in all these functional and structural abnormalities. The excessive airway narrowing observed in asthma may be related to the altered viscoelastic properties of lung parenchyma and airway wall, determining a decrease in the mechanical load opposing the airways' smooth muscle contraction. Indeed, an altered extracellular matrix deposition in asthma in humans, has been demonstrated. In addition, in the asthmatic lung, the matrix seems to contribute to airway inflammation, airway remodelling, and to those alterations of the smooth muscle function of the airway and morphology typical of asthma.

AB - The extracellular matrix is the main determinant of the structure and of mechanical behaviour of the lung. The extracellular matrix is also responsible for the mechanical interdependence between airway and parenchyma due to the alveolar attachments to the airways. Asthma is characterized by bronchial hyperresponsiveness, airway remodelling and inflammation, and an altered extracellular matrix may play a role in all these functional and structural abnormalities. The excessive airway narrowing observed in asthma may be related to the altered viscoelastic properties of lung parenchyma and airway wall, determining a decrease in the mechanical load opposing the airways' smooth muscle contraction. Indeed, an altered extracellular matrix deposition in asthma in humans, has been demonstrated. In addition, in the asthmatic lung, the matrix seems to contribute to airway inflammation, airway remodelling, and to those alterations of the smooth muscle function of the airway and morphology typical of asthma.

KW - Airway remodelling

KW - Airway smooth muscle

KW - Decorin

KW - Protgeiglycan

UR - http://www.scopus.com/inward/record.url?scp=65749098021&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=65749098021&partnerID=8YFLogxK

M3 - Article

C2 - 19522162

AN - SCOPUS:65749098021

VL - 71

SP - 27

EP - 30

JO - Monaldi Archives for Chest Disease

JF - Monaldi Archives for Chest Disease

SN - 1122-0643

IS - 1

ER -