Abstract
A rapid and specific diagnostic test for Alzheimer's disease (AD), the prevalent cause of dementia in the elderly, is currently unavailable. The aim of this study was to verify the validity of the recently proposed 'Eye Test' in the identification of AD patients, based on their supposed greater mydriatic response to cholinergic antagonists. We tested the pupillary response to the instillation of 0.01% tropicamide in 48 subjects: 15 patients with probable or possible Alzheimer's disease, five patients with vascular dementia (VD), 16 elderly controls (EC) and 12 young controls (YC). Mean pupil dilation in the treated eye at 30 and 40 min after drops instillation was not significantly different among the four groups. The mean change in anisocoria at 30 min was significantly greater in the AD group (0.90 mm, S.D. 0.83) than in the YC group (0.21 mm, S.D. 0.46), but no significant difference was found among the AD group, the EC group and the VD group. Our results, therefore, do not support the potential usefulness of the pupillary response to dilute tropicamide for identifying individuals with AD.
| Original language | English |
|---|---|
| Pages (from-to) | 171-177 |
| Number of pages | 7 |
| Journal | Archives of Gerontology and Geriatrics |
| Volume | 27 |
| Issue number | 2 |
| DOIs | |
| Publication status | Published - Oct 1998 |
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Keywords
- 'Eye test'
- Alzheimer's disease
- Diagnosis
- Elderly
ASJC Scopus subject areas
- Ageing
- Medicine(all)
Cite this
The 'eye test' in recognition of late-onset Alzheimer's disease. / Caputo, Ludovica; Casartelli, Margherita; Perrone, Chiara; Santori, Marisa; Annoni, Giorgio; Vergani, Carlo.
In: Archives of Gerontology and Geriatrics, Vol. 27, No. 2, 10.1998, p. 171-177.Research output: Contribution to journal › Article
}
TY - JOUR
T1 - The 'eye test' in recognition of late-onset Alzheimer's disease
AU - Caputo, Ludovica
AU - Casartelli, Margherita
AU - Perrone, Chiara
AU - Santori, Marisa
AU - Annoni, Giorgio
AU - Vergani, Carlo
PY - 1998/10
Y1 - 1998/10
N2 - A rapid and specific diagnostic test for Alzheimer's disease (AD), the prevalent cause of dementia in the elderly, is currently unavailable. The aim of this study was to verify the validity of the recently proposed 'Eye Test' in the identification of AD patients, based on their supposed greater mydriatic response to cholinergic antagonists. We tested the pupillary response to the instillation of 0.01% tropicamide in 48 subjects: 15 patients with probable or possible Alzheimer's disease, five patients with vascular dementia (VD), 16 elderly controls (EC) and 12 young controls (YC). Mean pupil dilation in the treated eye at 30 and 40 min after drops instillation was not significantly different among the four groups. The mean change in anisocoria at 30 min was significantly greater in the AD group (0.90 mm, S.D. 0.83) than in the YC group (0.21 mm, S.D. 0.46), but no significant difference was found among the AD group, the EC group and the VD group. Our results, therefore, do not support the potential usefulness of the pupillary response to dilute tropicamide for identifying individuals with AD.
AB - A rapid and specific diagnostic test for Alzheimer's disease (AD), the prevalent cause of dementia in the elderly, is currently unavailable. The aim of this study was to verify the validity of the recently proposed 'Eye Test' in the identification of AD patients, based on their supposed greater mydriatic response to cholinergic antagonists. We tested the pupillary response to the instillation of 0.01% tropicamide in 48 subjects: 15 patients with probable or possible Alzheimer's disease, five patients with vascular dementia (VD), 16 elderly controls (EC) and 12 young controls (YC). Mean pupil dilation in the treated eye at 30 and 40 min after drops instillation was not significantly different among the four groups. The mean change in anisocoria at 30 min was significantly greater in the AD group (0.90 mm, S.D. 0.83) than in the YC group (0.21 mm, S.D. 0.46), but no significant difference was found among the AD group, the EC group and the VD group. Our results, therefore, do not support the potential usefulness of the pupillary response to dilute tropicamide for identifying individuals with AD.
KW - 'Eye test'
KW - Alzheimer's disease
KW - Diagnosis
KW - Elderly
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UR - http://www.scopus.com/inward/citedby.url?scp=0031661965&partnerID=8YFLogxK
U2 - 10.1016/S0167-4943(98)00112-5
DO - 10.1016/S0167-4943(98)00112-5
M3 - Article
C2 - 18653162
AN - SCOPUS:0031661965
VL - 27
SP - 171
EP - 177
JO - Archives of Gerontology and Geriatrics
JF - Archives of Gerontology and Geriatrics
SN - 0167-4943
IS - 2
ER -