The 'eye test' in recognition of late-onset Alzheimer's disease

Ludovica Caputo, Margherita Casartelli, Chiara Perrone, Marisa Santori, Giorgio Annoni, Carlo Vergani

Research output: Contribution to journalArticle

Abstract

A rapid and specific diagnostic test for Alzheimer's disease (AD), the prevalent cause of dementia in the elderly, is currently unavailable. The aim of this study was to verify the validity of the recently proposed 'Eye Test' in the identification of AD patients, based on their supposed greater mydriatic response to cholinergic antagonists. We tested the pupillary response to the instillation of 0.01% tropicamide in 48 subjects: 15 patients with probable or possible Alzheimer's disease, five patients with vascular dementia (VD), 16 elderly controls (EC) and 12 young controls (YC). Mean pupil dilation in the treated eye at 30 and 40 min after drops instillation was not significantly different among the four groups. The mean change in anisocoria at 30 min was significantly greater in the AD group (0.90 mm, S.D. 0.83) than in the YC group (0.21 mm, S.D. 0.46), but no significant difference was found among the AD group, the EC group and the VD group. Our results, therefore, do not support the potential usefulness of the pupillary response to dilute tropicamide for identifying individuals with AD.

Original languageEnglish
Pages (from-to)171-177
Number of pages7
JournalArchives of Gerontology and Geriatrics
Volume27
Issue number2
DOIs
Publication statusPublished - Oct 1998

Fingerprint

dementia
Alzheimer Disease
Tropicamide
Vascular Dementia
Group
Anisocoria
Mydriatics
Control Groups
Cholinergic Antagonists
Pupil
Routine Diagnostic Tests
Dementia
Dilatation
pupil
diagnostic
cause

Keywords

  • 'Eye test'
  • Alzheimer's disease
  • Diagnosis
  • Elderly

ASJC Scopus subject areas

  • Ageing
  • Medicine(all)

Cite this

Caputo, L., Casartelli, M., Perrone, C., Santori, M., Annoni, G., & Vergani, C. (1998). The 'eye test' in recognition of late-onset Alzheimer's disease. Archives of Gerontology and Geriatrics, 27(2), 171-177. https://doi.org/10.1016/S0167-4943(98)00112-5

The 'eye test' in recognition of late-onset Alzheimer's disease. / Caputo, Ludovica; Casartelli, Margherita; Perrone, Chiara; Santori, Marisa; Annoni, Giorgio; Vergani, Carlo.

In: Archives of Gerontology and Geriatrics, Vol. 27, No. 2, 10.1998, p. 171-177.

Research output: Contribution to journalArticle

Caputo, L, Casartelli, M, Perrone, C, Santori, M, Annoni, G & Vergani, C 1998, 'The 'eye test' in recognition of late-onset Alzheimer's disease', Archives of Gerontology and Geriatrics, vol. 27, no. 2, pp. 171-177. https://doi.org/10.1016/S0167-4943(98)00112-5
Caputo, Ludovica ; Casartelli, Margherita ; Perrone, Chiara ; Santori, Marisa ; Annoni, Giorgio ; Vergani, Carlo. / The 'eye test' in recognition of late-onset Alzheimer's disease. In: Archives of Gerontology and Geriatrics. 1998 ; Vol. 27, No. 2. pp. 171-177.
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